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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Publication : Trends in cell biology

Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in cell biology - 08 Jul 2014

Rolando M, Buchrieser C

Link to Pubmed [PMID] – 25012125

Trends Cell Biol. 2014 Dec;24(12):771-8

Intracellular bacterial pathogens modulate the host response to persist and replicate inside a eukaryotic cell and cause disease. Legionella pneumophila, the causative agent of Legionnaires’ disease, is present in freshwater environments and represents one of these pathogens. During coevolution with protozoan cells, L. pneumophila has acquired highly sophisticated and diverse strategies to hijack host cell processes. It secretes hundreds of effectors into the host cell, and these manipulate host signaling pathways and key cellular processes. Recently it has been shown that L. pneumophila is also able to alter the transcription and translation machinery of the host and to exploit epigenetic mechanisms in the cells it resides in to counteract host responses.

http://www.ncbi.nlm.nih.gov/pubmed/25012125