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COVID-AMR (Impacts of the COVID-19 pandemic on antibiotic resistance) Collaboration : Laura Temime (Cnam) The COVID-19 pandemic started in a context of global efforts to prevent and control antimicrobial resistance. It has led to […]

Healthcare workers (HCW) are both priority groups for vaccinations and among the most influential in layperson’s vaccine decisions. Yet considerable vaccine hesitancy has been reported among HCW internationally, including in Belgium. During previous research […]

Scientific Partners Muriel Fartoukh, Sorbonne University Partners DATAD of the Direction de la Stratégie, des Études et des Statistiques (DSES), Caisse Nationale de l’Assurance Maladie (Cnam) Fundings This project is funded by the Direction […]

Emergence of antibiotic resistance (AMR) is a serious concern for Low and Middle Income Countries (LMICs). Unregulated use of antibiotics, a major AMR driver, is highly prevalent in LMICs, with medicine stores as key […]

Whooping cough is a respiratory disease caused by a bacterium (Bordetella Pertussis) which can, in certain cases and in particular in infants, be severe or even fatal (this is called malignant whooping cough). The […]

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Bacterial infections are responsible for a major public health burden. This is further exacerbated by antimicrobial resistance (AMR), which complicates the treatment of those infections and can lead to worse patient outcomes. Dealing with […]

The Transvaxx project aims to co-create intervention strategies with community and public health stakeholders that proactively mitigate vaccine hesitancy and maximize uptake of COVID-19 vaccination in Belgium. Mixed methods will be used, combining (i) […]

Malaria elimination requires elimination of all malaria species. Although there has been tremendous progress in the development of new interventions for P. falciparum malaria, the goal of malaria elimination cannot be considered achievable unless […]

Background Rabies continues to kill an estimated 59,000 people annually. In many African countries, there is little to no dog vaccination, which is essential to control rabies in the dog population and protect human […]

RECOVER is one of the 18 projects that the European Union has founded in response to the COVID-19 pandemic. It aims to obtain crucial unknown information about the disease through clinical Research to help […]

Retracing the global spread of Yersinia enterocolitica & the evolution of pathogenicity within its lineages, from a One Health perspective Abstract:The Yersinia species are instrumental models to investigate the emergence of pathogenicity in the […]

Covid-19 disease is characterized by dysregulated immune response leading to enhanced levels of circulating and lung inflammatory mediators. The latter include cytokines and lipid mediators (LMs) which results from increased phospholipid metabolism. The role […]

The project’s objective was to integrate and strengthen social sciences for community engagement in humanitarian settings (i.e., conflicts, natural hazards, infectious threats) drawing on some important lessons learnt globally during Covid-19 and previous epidemics […]

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This interdisciplinary program, funded by the ECDC, integrates both lectures and hands-on practical sessions provided by various host institutions to enhance surveillance, preparedness, and the ability to respond to outbreaks. Institutes included in the […]

Antibiotic resistance is one of the most serious threats to global health. The consequences for human health are particularly severe in low-resource countries, and in Africa in particular. The SARA project is funded by […]

Alphaviruses are arboviruses responsible for main outbreak as the one with Chikungunya virus. These viruses are transmitted to Human and animals through the bite of hematophagous arthropods, mostly mosquitoes from the genera Aedes and […]

The group of Chiara Zurzolo studies the function, structure and formation of tunneling nanotubes (TNTs) that connect neuronal cells (Gousset et al., 2009; Nat. Cell. Biol. 11:328; Delage et al., 2016; Sci Rep 6: […]

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Frontline health workers, who have a fundamental and influential role in Covid-19 vaccination efforts, are critical to understanding vaccine hesitancy, as it relates to the evolving information environment of Covid-19. Given this context, this […]

As part of the Sonar-Global COVID-19 research and response action, the Anthropology and Ecology of Disease Emergence unit (coordinator of the EC-funded Sonar-Global project) conducted a Vulnerability Assessment (VA), a research-action ethnographic methodology that identifies newly […]

About the Nanopore User Group: The Nanopore User Group at Institut Pasteur was established in 2019 with the primary goal of fostering collaboration, sharing knowledge, and advancing the application of Oxford Nanopore Technologies (ONT) […]

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

Sorry, this entry is only available in FR.

This multi-disciplinary study examines the changing nature and contexts of human contact with great apes and monkeys in equatorial Africa and the health consequences of that contact. Biomedical researchers have scrutinized the nature of […]

  Funding : DCI Monaco. In collaboration with epidemiologists from the Centre de Recherche Médicale et Sanitaire (CERMES) in Niamey, we are using recent advances in Geographic Information Systems and statistical methodology to investigate […]

Current research investigations  Antibiotic use and Staphylococcus aureus resistant to antibiotics, ASAR This study is a prospective pharmacoepidemiological investigation involving the establishment of a cohort of hospitalized individuals not initially colonized with S. aureus. […]

Monkeypox is an emerging Orthopoxvirus responsible for monkeypox disease, clinically similar to smallpox with a lethality of around 1 to 10%. This disease is a zoonosis initially transmitted from an animal reservoir and then […]

The Mathematical Modelling of Infectious Diseases Unit works closely with public health agencies in France and abroad to provide modelling support during epidemics so that our assessments can contribute to evidence-based decision making and […]

The molecular basis of the meningococcal pathogenesis is under active exploration by several groups in the world. Full genome sequencing failed to reveal specific determinants that could discriminate between transmissibility and non offending colonisation […]

The SRC Kinase Adaptor Phosphoprotein 2 (SKAP2), a broadly expressed protein recruiting protein partners to specific subcellular domains, plays a central role in multiple processes including TGFb response, integrin signalling, and cell migration. It […]

Background: Clinical trials are performed under optimal conditions where patients are highly selected without co-morbidities, clinical supervision is provided by specialists, and strict protocols are used to enhance patient compliance. Due to this, results […]

Funded by UNICEF Central African Republic, this investigation consists of a descriptive and comparative anthropological research on social, political, economic and health relations, formal and informal structures and practices in areas at risk of […]

In addition to a direct effect on the individual, the consumption of antiinfective drugs may have an indirect ecological benefit only visible at the population level. Moreover indirect ecological adverse effects may also exist […]

Zoonotic viruses are viruses that have an animal reservoir but may also infect humans. The 2009 A(H1N1)pdm09 influenza pandemic, the SARS epidemic in 2003, the recent emergence of a novel coronavirus in the Middle […]

The ERVB project aims to eliminate dog rabies in Bangui, capital of the Central African Republic, in 3 years (including canine vaccination campaigns). It is supported for 3 years (2019-2021) by the Coordination Organization […]

Recent experience with SARS and MERS-CoV reveals the hurdles of surveying pandemic risk of emerging infectious diseases. Initially, both diseases showed low transmissibility, insufficient to start pandemics. However, concerns were that, after a short […]

The Institut Pasteur has voluminous activities of microbial strain characterisation, in the context of epidemiological surveillance, biological resource centres collections management, and research. These activities involve National Reference Centers, WHO-collaborative centers, biological resources centers […]

The aim of this study is to capture the experiences and individual recollections of biomedical researchers at a broad range of European, African, North American, and Asian research institutions participating in the response to […]

Our research on Bordetella ranges from the population biology and epidemiology of various Bordetella species, including Bordetella pertussis (the major agent of whooping cough), to studies of host-pathogen relationships and immunity. Current research lines […]

Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]

Towards the development of diagnostic tests for Chagas disease and post-treatment monitoring by the use of specific markers of the parasite Trypanosoma cruzi and prognostic biomarkers of chronic phase of infection. Current methods available […]

Children’s Antibiotic Resistance colonization and Route of Transmission. The aim of this program is to assess the transmission of enterobacteria resistant to 3rd generation cephalosporines (EBRCIIIG) in hospitalized neonates in two low income countries […]

The ChinEBatRhab project aims to unravel the diversity and the circulation of rhabdoviruses in European and Chinese bats. It focused on an extensive surveillance in Chinese and European bats to investigate the prevalence and […]

The ComCor study is a nationwide case-control study which aims first to describe the locations and circumstances of recent SARS-CoV-2 infection, and second, to assess the role of different settings and activities in the […]

The aim of this study is to develop and evaluate a community-based home visit intervention in sub-Saharan Africa to improve the coverage of a timely birth dose of HBV vaccine and neonatal care practices […]

Context : Studying physiopathology of human diseases, focused in particular on genetic, immunological and environmental factors necessitate to access to human cohorts of healthy and diseased individuals and the corresponding bioresources. The rarity of […]

  Challenges in understanding the determinants of anti-infection agent escape New antibiotic components are being developed and, provided the necessary investments are made, new antibiotics may therefore become available within the next few years. […]

In collaboration with the Institute of Vertebrate Biology in Brno, Czech Republic (Dr. Natalia Martinkova and Markéta Harazim), the aim of this project is to study the mechanisms of lyssavirus infection in bats based […]

The main objective of the programme is to focus on finding key factors determining dengue transmission and dynamics in order to develop new tools and strategies for controlling dengue transmission. We will estimate the […]

The use of light from the abyss in life sciences   In the last decades, bioluminescent systems based on the expression of a luciferase and the addition of a luciferin to monitor the emission […]

  Nipah virus (NiV) is a bat-borne paramyxovirus found throughout South and South East Asia. With a case fatality ratio of >70% and no available treatment or vaccines, NiV has been identified by the […]

Our research on Corynebacterium diphtheriae and related bacterial pathogenic species, including Corynebacterium ulcerans,  aims at defining the diversity, evolution and epidemiology of the agents of diphtheria and related infections. We study human and animal clinical […]

Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries. Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due […]

Le projet EBO-SURSY est financé par l’Union Européenne (UE) à hauteur de 8 millions d’euros. Il a été lancé le 15 janvier 2017 dans 10 pays prioritaires pour une période de 5 ans.   […]

The purpose of this study is to conduct a “history of the present” of the West African Ebola Outbreak by investigating the personal experiences and recollections of people involved in the humanitarian response. In […]

It is well accepted that the outcome of infection in malaria depends upon interaction between the human host and Plasmodium spp. This is the result of forces of selection and escape acting on the […]

The emergence of Neisseria meningitidis serogroup X (NmX) in the African meningitis belt has urged understanding of this emergence as well as the development of diagnostic tools and vaccines for this serogroup, especially following […]

Summary of the project More than 60% of infectious diseases in humans are caused by pathogens likewise circulating in domestic animals and wildlife. Most of these pathogens are viruses whose genome is an RNA […]

  Funding: ANR, Fondation Raoul Follereau, Fondation SANOFI Espoir. In this new research program, we will conduct for the first time the simultaneous collection of environmental (plants and insects) and human samples in two […]

The Unit includes two National Reference Centers (CNR) and a WHO Collaborating Center. Our interests are the population dynamics of bacterial enteric pathogens such Salmonella, Shigella/Escherichia coli and Vibrio, with a special focus on […]

The classical biotype of Vibrio cholerae O1 was responsible for the first six cholera pandemics, but is relatively unknown, with only 20 genome sequences (50% of which come from the same geographic area) for […]

The FiTeRaD (Field Tests for Rabies Diagnostic) project aims to develop and validate, in laboratory and in the field, the first point of care tests (POCT) for the rapid detection of the etiological agent […]

Detailed objectives of the research program 1) How lyssavirus infection moves in both space and in time and the role played by ecological factors in the dispersal of lyssaviruses in bats and dogs. The […]

Non-segmented negative strand RNA viruses are characterized by an intrinsic genome instability, the result of an error-prone RNA dependant RNA polymerase. To date, most viral populations have been characterized by their consensus genome sequences. […]

Cholera is thought by many to be a disease of the Victorian era. However, Yemen has recently experienced one of the largest ever cholera epidemics. The first cases were declared in September 2016, and […]

High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]

Meningococcal components (pathogen associated molecular patterns, PAMPs) such as the LOS, peptidoglycan and membrane proteins are responsible for the induction of systemic inflammatory response. Recent and previous works from our group contributed in the […]

Groupe Arbovirus (GA) de l’Unité Environnement et Risques Infectieux a été créé en 2014. Le GA travaille sur les virus transmis par les arthropodes (Arbovirus), avec un intérêt pour les arbovirus émergents ou réémergents […]

Funding: ANRS & EC. The main research objectives of this multidisciplinary network funded by the ANRS and the EC are the assessment of the burden of HCV infection and disease in Egypt, the study […]

As a follow-up to ANRS funding for a feasibility study (ANRS 12232), I received in 2011 funding from ANRS for an in-depth anthropological study of hepatitis B and vaccination in Bobo Dioulasso and the […]

Little is known about the emergence and spread of the first antibiotic-resistant populations. It is believed, for example, that the very common penicillinase gene, blaTEM-1, discovered for the first time in E. coli in Greece […]

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis […]

The objective of this research project is to understand the molecular and functional basis of the memory B-cell antibody response to the SARS-CoV-2 Spike protein. One of the key goals of this research program […]

The i-Bird program was devoted to explore the ability of MRSA and ER3GC to disseminate within hospital clinical departments. This program involved tracing the clonal dissemination of MRSA and ER3GC among hospitalized patients and […]

i-Predict is a multicentric controlled randomized trial on genital infection with Chlamydia trachomatis (Ct), which is the most common bacterial sexually transmitted infection (STI), especially among young women. Mostly asymptomatic, this infection can be […]

I-Share is an Internet-based Students HeAlth Research Enterprise. It is an entirely new, prospective cohort of 30,000 students registered in the first years of study at the Universities of Bordeaux and Versailles-Saint-Quentin during five years and followed […]

Dengue causes significant morbidity and mortality worldwide, with millions of symptomatic cases occurring throughout the central band of the world each year. Large increases in cases are often associated with a shift in predominant […]

Various workshops on the diagnosis of rabies are regularly organized at international level, in the form of theoretical courses and practical work sessions. These workshops are organized in close collaboration with local partners and […]

  The InterVax project on practices and opinions of travellers with regard to vaccination is a comparative analysis of travellers’ general perception of vaccination on the one hand and their specific perception of travel […]

Although the risk of HCV acquisition during certain medical procedures, such as dialysis or blood transfusion, has been previously estimated for patients from high-income countries, the overall risk of HCV acquisition associated with hospital […]

Despite intensive research efforts on arthropod-borne viruses (arboviruses), many aspects related to immunological consequences of arthropod vector-derived salivary factors are unknown, especially those occurring at the injection site. During a blood meal, arboviruses are […]

Join us on Google groups! KlebNET e-mail distribution list on Google groups. Please ask for registration, by explaining your interest in Klebsiella research or surveillance and providing your institution, so that the moderators can […]

Protozoan parasites of the genus Leishmania generate severe human diseases termed Leishmaniases. Due to their frequency and the severity of certain clinical forms, these diseases represent a major public health problem and limit the […]

(Last update: 10/10/2023) Context In early 2020, the first French death attributed to the SARS-CoV-2 virus was a teacher from Crépy-en-Valois, a city north of Paris. The intense circulation of the novel coronavirus in […]

(Collaborators: Alexandre Manirakiza, Sandrine Moussa, Aude Boulay, Olga Sakanga, Sébastien Breurec, Mirdad Kazanji(IP Bangui), Lenaig Le-Fouler, Muriel Vray (IP Paris)). Funding : Fondation de France. Accounting for HIV serological status in patients is critically […]

  Determinants of the spread and competitiveness of multiresistant bacteria  In 2000, we investigated whether pneumococcal resistance to penicillin G in a child population could be controlled by modifying the use of antibiotics in […]

(Collaborators : Tamara Giles-Vernick, Abdoulaye Traoré, Sodiomon B. Sirima). Funded by the World Health Organization, 2010-11. The primary aim was to test the acceptability and feasibility of an intervention package for the community management […]

Pathogen detection and characterization methods in public health infectious disease surveillance rely on the identification of agents that are already known to be associated with a particular clinical syndrome. Metagenomics, as an emerging field […]

Since 2002 a centralized storage of therapeutic or preventive medications of bacterial infections in the community (MIBAC) has been initiated. Reimbursements for all systemic antibiotics (class J01 of the Anatomical Therapeutic classification), as well […]

Zoonotic transmissions are a major global health risk, with human-animal contact frequently raised as a driver of emergence. Studies of zoonotic transmission risks are often piecemeal, targeting bushmeat, specific animal reservoirs, or single pathogens. […]

We performed miRNome on monocytes from healthy donors living in Bangkok, previously checked for their antibodies against DENV. We hypothesized that individuals without antibodies against any serotype of DENV may represent a DENV-resistant population, […]

Project MOD-COV (Modelling of the hOspital Dissemination of SARS-CoV-2) In the context of SARS-CoV-2 pandemic, healthcare institutions are confronted to major challenges. First the community spread is leading to a large demand in available […]

Despite advances in modern biology and medicine, antibiotic-resistant bacteria (ARB) have spread in the community and in hospitals over the last decades, becoming a major public health problem. Mathematical modeling and computer simulations are […]

Neonatal acquisition of ESBL-PE in the community of a Low-Income Country  Severe bacterial infections are a leading cause of neonatal deaths, with low income countries (LICs) bearing the highest burden. In LICs, neonatal bacterial […]

Chronic infection with hepatitis B virus (HBV) is an important cause of premature adult deaths in sub-Saharan Africa (SSA), due to liver cancer or cirrhosis. To reduce the disease burden, it is critical to […]

When individuals get infected by a pathogens, they will develop antibodies against that pathogen that will continue to circulate in their blood. By using assays that can detect these antibodies, we can develop an […]

Bacterial resistance to antibiotics has become a major public health issue. A recent report, delivered to the Minister of Health in September 2015, pointed out 158,000 cases of infections by antibiotic-resistant bacteria annually in […]

In 1970, ten years after the beginning of the 7th pandemic (Indonesia, 1961), cholera hit Africa, where it has remained entrenched. Three decades later, the reported incidence of indigenous cholera in sub-Saharan Africa was […]

The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]

Le PIB est le pôle bactériologique de la CIBU de l’Institut Pasteur. Anciennement appelé Centre d’Identification Moléculaire des Bactéries (CIMB), le laboratoire prend le nom de PIB en 2008. La particularité du PIB est […]

Le PIV est le pôle de virologie de la CIBU. Créé depuis 2003, il intervient dans plusieurs domaines : L’investigation de cas cliniques particuliers, à la demande de l’Institut de Veille Sanitaire (InVS), de la […]

The Genotyping of Pathogens Pole, the centre for microbial genomics of the Environment and Infectious Risks Research and Expertise Unit, provides skills with genotyping and genomics technologies for the characterization of sensitive pathogens and/or […]

Klebsiella pneumoniae is one of the most urgent threats to public health given its increasing resistance to antimicrobial agents including carbapenems, considered as last-resort antibiotics.  In this project we aim to understand the ecological, epidemiological and […]

Dog constitutes one of the major reservoirs of the rabies virus (RABV), and the main vector of rabies in humans (nearly 60,000 deaths per year worldwide), in particular in the endemic areas in Asia […]

About PREDEMICS Infectious diseases have always been a threat to the human population, but since the end of World War II, medical progress fostered the hope that pathogens could be controlled if not eradicated […]

Previously considered to cause limited human infection and mild disease, Zika virus (ZIKV) caused several large outbreaks in Yap Island in 2007, in French Polynesia in 2013-2014 and the 2015-2016 epidemic across the Americas […]

Voluntary organizations provide essential support to vulnerable populations and front-line health responders to the COVID-19 pandemic. The French Red Cross (FRC) is prominent among organizations offering health and support services in the current crisis. […]

The polysaccharide-encapsulated bacteria Neisseria meningitidis, Haemophilus influenzae (Hi) and Streptococcus pneumoniae are leading causes of serious bacterial infections. Beta lactams are the first line antibiotics in the treatment. These bacteria share the same ecological […]

  The ResiVax project, entitled SoVax for the French context study, addresses a crucial health issue, vaccine coverage and its social determinants, at a specific stage of life, student life. It relies on the […]

Invasive pneumococcal diseases (IPDs) are a major cause of morbidity and mortality worldwide. The mechanisms responsible for the epidemiological patterns of susceptible- and resistant- IPDs which include a yearly winter peak are still poorly […]

Rabies is an untreatable disease of humans due to lyssaviruses and Rabies virus (RABV) in particular. RABV is a highly neurotropic virus which prevent inflammation during the early phase of infection. In the brain, […]

In this part of our project we investigate the role of secreted phospholipases A2 in lung inflammation and injury in premature babies, in collaboration with Dr. Daniele Di Luca pediatrician in the hospital Antoine-Béclère. […]

Statistical and Mathematical Modeling in Biological Applications — SaMMBA Seminars are currently accessible onsite (seminar + buffet lunch) and online (link provided by email). [It is possible to contact any of the organisers to […]

The main objective of the SARAH project is to study the determinants of antibiotic resistant bacteria dissemination at the animal-human interface. We develop a methodological research based on mathematical modelling and the analysis of […]

Cliquer ici pour aller à l’enquête Confinement, mesures barrières, limitation des rassemblements etc. Les mesures de prévention actuellement mises en place sont inédites. Elles ont fondamentalement modifié les contacts que nous avons au quotidien. […]

Sonar-Global is a research project funded by Horizon 2020 (EU) aiming to build a social sciences network to prevent and respond to infectious threats and antimicrobial resistance. All Sonar-Global partners work in the field […]

Healthcare-associated infections (HAI) have been occurring with increased incidence and severity over the last decades, becoming a major public health issue. A wide range of control strategies is already available, including hygiene measures, barrier […]

To design effective ways to mitigate the spread of a pathogen in a population, it is important to first have a good understanding of the transmission characteristics of the pathogen as well as the […]

Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2 virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is designed to target […]

Based on the recent identification of the non-structural proteins NS3, NS4B and NS5 of dengue virus (DENV) as the main targets for T cell responses in humans, we have designed a minimal DENV antigen, […]

Combining bioinformatics and immunobiology towards the identification of  Trypanosoma vivax specific markers. Despite closely related, South American and West African T. vivax are genetically distinct and these populations largely differ from those circulating in […]

The aim of this project is to develop a more grounded, robust historical context for the emergence of HIV. While some hypotheses for the emergence of HIV have been suggested, they have been offered […]

EVA-GLOBAL objective is to generate the largest accessible collection of human, animal and plant viruses in the world and move beyond the current state-of-the-art to provide an increasingly valuable resource and service to the […]

(Collaborators: Sébastien Breurec, Ionela Gouandjika,Thierry Frank, Caroline Martin (IP Bangui), Petulla bata, Jean Gody (Complexe pédiatrique Bangui), Tamara Giles-Vernick, Loic chartier, Muriel Vray (IP Paris)). Funding : The fondation Total. Diarrhea ranks as the […]

In order to understand the spread of infectious diseases, we are often interested in the transmission relationship between pairs of cases. The use of pathogen sequences has revolutionized our ability to characterize the relationship […]