Our research on Bordetella ranges from the population biology and epidemiology of various Bordetella species, including Bordetella pertussis (the major agent of whooping cough), to studies of host-pathogen relationships and immunity.
Current research lines include:
(i) Diversity, evolution and transmission of Bordetella using genomics, transcriptomics and proteomics
(ii) the impact of vaccination on population evolution
(iii) Identification and functional analysis of bacterial determinants of malignant pertussis (most severe infections)
(iv) Impact of genetic variation on host-pathogen relationships
(v) Vaccine-induced and infection-induced immunity to Bordetella pertussis
We apply our research to the developments of diagnostics, identification methods and genomics-based strain genotyping tools.
Our projects on Bordetella leverage and reinforce the resources and expertise of the French National Reference Center for Whooping cough and other Bordetella infections (web pages in French).