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  • program_project
  • nrc
  • whocc
  • project
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  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2016
Status
Ongoing
Members
9
Structures
8

About

Zika virus is an arbovirus responsible for recent epidemics in Polynesia and in the Americas. Clinical descriptions range from mild flu-like syndromes to rare but severe neurological complications such as Guillain-Barré syndrome and encephalitis in adults, and congenital malformations in fetuses of infected pregnant women. We hypothesized that host genes may contribute to these variations.
We assessed the consequences of Zika virus infection in the Collaborative Cross strains and we reported large variations in their susceptiblity, ranging from low plasma viral load with no clinical signs, to very high viral load, high mortality and neuroinflammation. Our results clearly demonstrate the critical importance of host genetic background in the response to Zika virus infection. We are now working towards the identification of specific genes and biological functions which influence these differences using a combination of mouse crosses and cellular models.

Fundings