COVID-AMR (Impacts of the COVID-19 pandemic on antibiotic resistance)
Collaboration : Laura Temime (Cnam)
The COVID-19 pandemic started in a context of global efforts to prevent and control antimicrobial resistance. It has led to a major disruption of the organization of care, antibiotic prescription, and the implementation of control and prevention strategies against the transmission of respiratory infections, all of which being key regulating or promoting factors of antimicrobial resistance spread in the community and in hospitals. Considering the pleiotropic effect of the pandemic, it is hard to predict how it has impacted the spread of antibiotic resistant bacteria both in the community and in health care settings. Better understanding this impact is crucial to improve care organisation for futures epidemics and pandemics of severe respiratory diseases and avoid side effects from a public health standpoint.
Community COVID-AMR. We develop mathematical models to analyse jointly the dynamics of resistant bacteria (with a specific focus on pneumococcus) and SARS-CoV-2 in the community and understand better the drivers and interactions that can lead to the observed trends of bacterial infections in 2020.
Hospital COVID AMR. The aim of the project is to evaluate whether the burden in COVID-19 patients in hospitals during the first two years of the pandemic has changed the incidence of resistant infections in these settings. We analyse national surveillance data of COVID-19 cases and antibiotic resistance in hospitals that include more than 1,400 hospitals from the 1st of March 2020 to December 2021 using statistical models and mathematical models to identify the key mechanisms by which the pandemic may have affected antibiotic resistant bacteria transmission in these settings, as well as the level of resistance, and assess prevention and control strategies.
- Conservatoire National des arts et métiers
- Institut Pasteur
- Santé Publique France
Funding: Labex IBEID, INSERM