Frontline health workers, who have a fundamental and influential role in Covid-19 vaccination efforts, are critical to understanding vaccine hesitancy, as it relates to the evolving information environment of Covid-19. Given this context, this study aims to increase understanding of the spread and use of (mis)information among frontline health workers in Guinea and Ghana. Both are countries with previous experience with viral outbreaks research and with ongoing collaborations for Covid-19 vaccine research. More specifically, we assessed the impact of vaccine controversies on human behaviour (vaccine hesitancy) and the social dynamics (concerns and anxieties) that underpin vaccine sentiments. The overarching aim of this project is to provide the Global Health community with evidence that can improve health strategies locally and globally.