Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2015
Ending Date
01
Jan 2018
Status
Ongoing
Members
4
Structures
4
Instituts
1

About

Acquisition of antibiotic resistant bacteria and development of the gut microbiome in neonates in low-income countries.

Antibiotic resistance represents a major health issue worldwide. The situation is particularly acute in low-income countries (LIC), due to misuse of antibiotics, counterfeit drugs or substandard hygiene and living conditions. In particular, infections and gut colonization by extended spectrum beta-lactamase- and carbapenemase-producing Enterobactericeae (ESBL- and C-PE) is becoming extremely worrisome. The gut microbiome plays a major role on multiple aspects of health and, most notably, influences the colonization by multiresistant bacteria (MRB).
In this project we propose to further characterize the factors that shape the human microbiome in early infancy and the establishment of pathogenic MRB in Madagascar. For this purpose, we carry out a multi-disciplinary project involving data collection, deep sequencing and mathematical modelling. Nested in the BIRDY* program we follow 400 children over their first month of life and frequently collect stool samples together with medical and socio-demographic information.
The aim is (1) to improve our knowledge of microbiome composition and its dynamics in early infancy in a LIC, Madagascar; (2) to provide genomic knowledge on antibiotic resistant strains and resistance genes circulating in this island; and (3) using mathematical modelling, to identify factors and ecological interactions influencing the outgrowth of pathogenic bacteria in new-borns, including MRB and decipher the role of the gut microbiome.  The project is funded by the Institut Pasteur (mission PTR) and the Foundation Monaco.

*The BIRDY program is a multi-centric cohort which aims at determining the burden of childhood and neonatal infections caused by antibiotic resistant bacteria in LIC. It is based on an international pediatric cohort implemented within the Institut Pasteur International Network (IPIN).

Keywords: Gut Microbiota, Antibiotic-resistance, Metagenomics, Dynamics, Mathematical Modelling, Madagascar, Pathogens Interactions

Fundings