High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based typing systems are being developed to replace or complement classical epidemiological markers and have the potential to provide ultimate resolution for strain discrimination. Genome sequences may also be used to extract medically important features such as virulence and resistance genes in real time. In this project, we set-up and maintain a bioinformatics platform to host genomic and nomenclature databases for bacterial pathogens of public health importance, including Klebsiella pneumoniae and Listeria monocytogenes. The genomic databases are accessible at http://bigsdb.pasteur.fr.