Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2015
Ending Date
01
Jan 2022
Status
Ongoing
Members
6
Structures
1

About

In addition to a direct effect on the individual, the consumption of antiinfective drugs may have an indirect ecological benefit only visible at the population level. Moreover indirect ecological adverse effects may also exist (bacterial resistance, vaccine escape). To fight against invasive pneumococcal diseases in the community (IPD) and S.pneumoniae resistance to antibiotics, France has initiated two public health interventions, the campaign to promote better-targeted antibiotic use, which has led to a significant decrease in their prescriptions, and the promotion of 7-valent pneumococcal conjugate vaccine (PCV-7), followed by PCV-13. Despite the decline in the incidence of IPD due to vaccine serotypes, the benefit of vaccination has been reduced or neutralized by the serotype replacement phenomenon in all age groups. In accordance with works that suggest that bacterial complications are important in the consequences of infections, and beyond that reduced exposure to antibiotics may be associated with a re-increase in some IPD mainly of sensitive strains, a significant increase of IPD in 16-64 yrs was estimated in 2008, compared with those in 1998. It is therefore important to study the temporal dynamics of IPD in relation to public health interventions. This project is funded by the Fondation pour la Recherche Médicale (FRM) and the Université de Versailles Saint Quentin (PhD fellowship).

Keywords: Invasive pneumococcal diseases, Time series, Antibiotics, PCV vaccination