Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Pierre Gounon
Virus influenza purifié, agent de la grippe. Ce virus enveloppé possède un génome fragmenté : 8 segments d'ARN négatif protégés par une nucléocapside.
Project

KerArbo: Role of salivary factors of Aedes albopictus in the permissiveness of human skin cells to Dengue and Chikungunya viruses

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2012
Ending Date
30
Sep 2016
Status
Ongoing
Members
3
Structures
2

About

Despite intensive research efforts on arthropod-borne viruses (arboviruses), many aspects related to immunological consequences of arthropod vector-derived salivary factors are unknown, especially those occurring at the injection site. During a blood meal, arboviruses are deposited into the host skin together with saliva containing a wide array of biologically active, yet poorly understood molecules.

Mounting evidence indicates that many arthropod viruses have evolved to take advantage of specific salivary proteins to facilitate the establishment of an infection. Arboviruses bypass the barrier function of the skin which becomes a port of entry, a place of residence and an exit site. Despite the importance of the skin as an entry site for these viruses, our current knowledge of the skin’s immune system lags behind what we know about immune events in the spleen, lymph nodes or blood. The events that occur at the bite-site are still poorly understood and insights into processes such as the modulation of human immune functions by arthropod saliva may provide new targets to combat arboviruses.

Dengue (DENV) and Chikungunya (CHIKV) viruses are two emerging arboviruses that are transmitted to humans by the bite of Aedes sp. mosquito vectors. The purpose of the KerARBO proposal is to shed light on early interactions of DENV and CHIKV with the skin’s immune system, taking into account any changes induced by Aedes albopictus saliva.

KerARBO proposal involves 3 partners (IRD, Pasteur Institute and CNRS)

Fundings