Timeline

Laurence Mulard
Head of Structure
25 Aug 2018
project

GlycoShig1

Read more
25 Aug 2018
patent

Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides

Read more
25 Aug 2018
patent

Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri (SF6)

Read more
25 Aug 2018
patent

Glycoconjugates and use thereof as vaccines against Shigella flexneri serotype 3a and X

Read more
25 Aug 2018
patent

Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri

Read more
15 Aug 2018
publication

Bacteriophage Sf6 Tailspike Protein for Detection of Pathogens

Read more
24 Mar 2017
publication

Dirhamnolipids secreted from Pseudomonas aeruginosa modify anjpegungal susceptibility of Aspergillus fumigatus by inhibiting β1,3 glucan synthase activity

Read more
04 Jul 2016
publication

Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a

Read more
01 Jul 2016
publication

Efficient iterative synthesis of O-acetylated tri- to pentadecasaccharides related to the lipopolysaccharide of Shigella flexneri type 3a via di- and trisaccharide glycosyl donors

Read more
07 Jun 2016
team

Group: Carbohydrates and Bioconjugates

Read more
27 Mar 2016
project

A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial

Read more
27 Mar 2016
project

FlexBiVac

Read more
21 Mar 2016
publication

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

Read more
12 Sep 2015
project

CarbUniVax

Read more
04 Sep 2015
publication

Investigation on the synthesis of Shigella flexneri-specific oligosaccharides using disaccharides as potential transglucosylase acceptor substrates

Read more
08 Jul 2015
project

Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools

Read more
03 Jul 2015
project

Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components

Read more
11 May 2015
team

Chemistry of Biomolecules

Read more
14 Feb 2015
publication

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

Read more
07 Jan 2015
publication

Computer-aided design of sequence libraries for the engineering of transglucosylase binding subsites to enable glucosylation of an unnatural disaccharide motif of relevance for bacterial antigen synthesis

Read more
19 Nov 2014
publication

Development and evaluation of a dipstick diagnostic test for Neisseria meningitidis serogroup X

Read more
11 Sep 2014
publication

Synthesis of the zwitterionic repeating unit of the O-antigen from Shigella sonnei and chain elongation at both ends

Read more
21 Aug 2014
publication

Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation

Read more
28 Jun 2014
publication

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

Read more
20 Dec 2013
publication

CGTase-catalysed cis-glucosylation of L-rhamnosides for the preparation of Shigella flexneri 2a and 3a haptens

Read more
11 Oct 2013
publication

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxydation

Read more
08 May 2013
publication

Structural studies of the O-acetyl containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof

Read more
30 Oct 2012
publication

Applying pairwise combinations of amino acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides

Read more
16 Mar 2012
publication

Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain

Read more
01 Jan 2012
publication

Multidisciplinary approaches to study O-antigen:antibody recognition in support of the development of synthetic carbohydrate-based enteric vaccines

Read more
24 May 2011
publication

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance

Read more
28 Oct 2010
publication

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy

Read more
22 Jul 2010
publication

A pH-based high-throughput screening of sucrose-utilizing transglucosidases for the development of novel enzymatic glucosylation tools

Read more
23 Jul 2009
publication

From epitope characterization to the design of semi-synthetic glycoconjugate vaccines against Shigella flexneri 2a infection

Read more
24 Jun 2009
publication

Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

Read more
01 Jun 2009
publication

Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides

Read more
01 Apr 2009
publication

Efficient synthesis of six tri- to hexasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigen, including a study on acceptors containing N-trichloroacetylglucosamine versus N-acetylglucosamine

Read more
27 Mar 2009
publication

Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a

Read more
01 Mar 2009
publication

Synthesis of L-rhamnose and N-acetyl-D-glucosamine derivatives with glucansucrases

Read more
15 Feb 2009
publication

A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection

Read more
13 Oct 2008
publication

Synthesis of 2 tetra- and 4 pentasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigens from a common tetrasaccharide intermediate

Read more
03 Sep 2008
publication

Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens

Read more
23 Jul 2008
publication

Investigation towards bivalent chemically defined glycoconjugate immunogens prepared from acid-detoxified lipopolysaccharide of Vibrio cholerae O1, serotype Inaba

Read more
10 Jul 2008
publication

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody

Read more
10 Jul 2008
publication

Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?

Read more
15 Jun 2008
publication

Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted--D-glucopyranose derivatives and use thereof

Read more
01 Apr 2008
publication

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position

Read more
01 Jan 2007
publication

[Carbohydrates and vaccines: from purified polysaccharides to semi-synthetic glycoconjugate vaccines]

Read more
01 Feb 2006
publication

Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine

Read more
26 Oct 2005
publication

Toward a better understanding of the basis of the molecular mimicry of polysaccharide antigens by peptides: the example of Shigella flexneri 5a

Read more
01 Sep 2005
publication

On the preparation of carbohydrate-protein conjugates using the traceless Staudinger ligation

Read more
19 Apr 2005
publication

Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues

Read more
18 Feb 2005
publication

Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection

Read more
01 Jan 2005
publication

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

Read more
17 Nov 2004
publication

Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs

Read more
20 Jun 2004
publication

Total synthesis of a tetra- and two pentasaccharide fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a

Read more
19 May 2004
publication

A structural basis for the inhibition of the NS5 dengue virus mRNA 2′-O-methyltransferase domain by ribavirin 5′-triphosphate

Read more
26 Apr 2004
publication

Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease

Read more
20 Feb 2004
publication

Blockwise approach to fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a: convergent Synthesis of a decasaccharide representative of a dimer of the branched repeating unit

Read more
18 Aug 2003
publication

Conformational studies of the O-specific polysaccharide of Shigella flexneri 5a and of four related synthetic pentasaccharide fragments using NMR and molecular modeling

Read more
01 Mar 2003
publication

Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets

Read more
16 Oct 2002
publication

Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen

Read more
08 Aug 2002
publication

Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation

Read more
09 Jul 2002
publication

Convergent synthesis, NMR and conformational analysis of tetra- and pentasaccharide haptens of the Shigella flexneri 5a O-specific polysaccharide

Read more
19 Feb 2002
publication

Synthesis and NMR study of a linear pentasaccharide fragment of the Shigella flexneri 5a O-specific polysaccharide

Read more
01 Jan 2002
publication

Vaccins polysaccharidiques

Read more
01 Nov 2001
publication

Conformation of the O-specific polysaccharide of Shigella dysenteriae type 1: molecular modeling shows a helical structure with efficient exposure of the antigenic determinant alpha-L-Rhap-(1–>2)-alpha-D-Galp

Read more
08 Aug 2001
publication

MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis

Read more
01 Apr 2001
publication

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: improvement by alpha-boranophosphate substitution

Read more
27 Dec 2000
publication

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance

Read more
27 Sep 2000
publication

Linear synthesis of the methyl glycosides of tetra- and pentasaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen

Read more
01 Jan 2000
publication

Linear synthesis of the methyl glycosides of tri-, tetra-, and pentasaccharide fragments of the Shigella flexneri serotype 5a O-antigen

Read more
01 Jan 2000
publication

Synthesis of the methyl glycosides of a di- and two trisaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen

Read more
01 Jan 2000
publication

First synthesis of a branched pentasaccharide representative of the repeating unit of the Shigella flexneri serotype 5a O-antigen

Read more
01 Sep 1999
publication

Immunochemical characterization of an Ogawa-Inaba common antigenic determinant of Vibrio cholerae O1

Read more
01 Jan 1999
publication

Synthesis of the methyl glycosides of a tri- and tetrasaccharide fragment specific for the Shigella flexneri serotype 5a O-antigen. A reinvestigation

Read more
01 Sep 1998
publication

Synthesis of tri- and tetrasaccharide fragments of the Shigella dysenteriae type 1 O-antigen deoxygenated and fluorinated at position 3 of the methyl alpha-D-galactopyranoside terminus

Read more
01 Jul 1998
publication

Binding of modified fragments of the Shigella dysenteriae type 1 O-specific polysaccharide to monoclonal IgM 3707 E9 and docking of the immunodeterminant to its modeled Fv

Read more
01 Jan 1997
publication

Investigation by NMR spectroscopy and molecular modeling of the conformations of some modified disaccharide antigens for Shigella dysenteriae type 1

Read more
01 Sep 1995
publication

Synthesis of specifically deoxygenated disaccharide derivatives of the Shigella dysenteriae type 1 O-antigen

Read more
01 Jun 1994
publication

Fluorination at position 6 of derivatives of methyl alpha-D-galactopyranoside

Read more
01 Jun 1994
publication

Synthesis of specifically monofluorinated ligands related to the O-polysaccharide of Shigella dysenteriae type 1

Read more
01 Jan 1994
publication

Synthesis of methyl O-alpha-L-rhamnopyranosyl-(1–>2)-alpha-D-galactopyranosides specifically deoxygenated at position 3, 4, or 6 of the galactose residue

Read more
01 Jan 1993
publication

Synthesis of 2′-deoxy-2′-spirocyclopropyl cytidine as potential inhibitor of Ribonucleoside Diphosphate Reductase

Read more