Timeline
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Laurence Mulard
Head of Structure
20 Nov 2023
publication
Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose
Read more27 Apr 2022
publication
The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella.
Read more07 Mar 2022
publication
Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella: State-of-the-Art for a Monovalent Prototype and Challenges.
Read more01 Feb 2022
publication
Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans.
Read more13 Oct 2021
publication
Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides.
Read more15 Jul 2021
publication
Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide
Read more01 Apr 2021
publication
Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study.
Read more26 Mar 2021
publication
Exploratory N-Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides.
Read more05 Feb 2021
publication
Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O-Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core.
Read more28 Jan 2021
publication
Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens.
Read more01 Jan 2019
publication
Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human.
Read more01 Dec 2018
publication
ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri.
Read more25 Aug 2018
25 Aug 2018
patent
Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides
Read more25 Aug 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri (SF6)
Read more25 Aug 2018
patent
Glycoconjugates and use thereof as vaccines against Shigella flexneri serotype 3a and X
Read more25 Aug 2018
patent
Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri
Read more15 Aug 2018
publication
Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens.
Read more24 Mar 2017
publication
Dirhamnolipids secreted from Pseudomonas aeruginosa modify anjpegungal susceptibility of Aspergillus fumigatus by inhibiting β1,3 glucan synthase activity.
Read more04 Jul 2016
publication
Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a
Read more01 Jul 2016
publication
Efficient Iterative Synthesis of O-Acetylated Tri- to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di- and Trisaccharide Glycosyl Donors.
Read more07 Jun 2016
27 Mar 2016
27 Mar 2016
21 Mar 2016
publication
A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity
Read more12 Sep 2015
04 Sep 2015
publication
Investigation on the synthesis of Shigella flexneri-specific oligosaccharides using disaccharides as potential transglucosylase acceptor substrates
Read more08 Jul 2015
project
Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools
Read more03 Jul 2015
project
Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components
Read more11 May 2015
14 Feb 2015
publication
Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate
Read more07 Jan 2015
publication
Computer-aided design of sequence libraries for the engineering of transglucosylase binding subsites to enable glucosylation of an unnatural disaccharide motif of relevance for bacterial antigen synthesis
Read more11 Sep 2014
publication
Synthesis of the zwitterionic repeating unit of the O-antigen from Shigella sonnei and chain elongation at both ends
Read more21 Aug 2014
publication
Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation
Read more28 Jun 2014
publication
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity
Read more20 Dec 2013
publication
CGTase-catalysed cis-glucosylation of L-rhamnosides for the preparation of Shigella flexneri 2a and 3a haptens
Read more11 Oct 2013
publication
Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxydation
Read more08 May 2013
publication
Structural studies of the O-acetyl containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof
Read more30 Oct 2012
publication
Applying pairwise combinations of amino acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides
Read more16 Mar 2012
publication
Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain
Read more01 Jan 2012
publication
Multidisciplinary approaches to study O-antigen:antibody recognition in support of the development of synthetic carbohydrate-based enteric vaccines
Read more24 May 2011
publication
Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance
Read more28 Oct 2010
publication
Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy
Read more22 Jul 2010
publication
A pH-based high-throughput screening of sucrose-utilizing transglucosidases for the development of novel enzymatic glucosylation tools
Read more23 Jul 2009
publication
From epitope characterization to the design of semi-synthetic glycoconjugate vaccines against Shigella flexneri 2a infection
Read more24 Jun 2009
publication
Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen
Read more01 Jun 2009
publication
Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides
Read more01 Apr 2009
publication
Efficient synthesis of six tri- to hexasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigen, including a study on acceptors containing N-trichloroacetylglucosamine versus N-acetylglucosamine
Read more27 Mar 2009
publication
Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a
Read more01 Mar 2009
publication
Synthesis of L-rhamnose and N-acetyl-D-glucosamine derivatives with glucansucrases
Read more15 Feb 2009
publication
A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection
Read more13 Oct 2008
publication
Synthesis of 2 tetra- and 4 pentasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigens from a common tetrasaccharide intermediate
Read more03 Sep 2008
publication
Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens
Read more23 Jul 2008
publication
Investigation towards bivalent chemically defined glycoconjugate immunogens prepared from acid-detoxified lipopolysaccharide of Vibrio cholerae O1, serotype Inaba
Read more10 Jul 2008
publication
Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?
Read more10 Jul 2008
publication
Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody
Read more15 Jun 2008
publication
Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted--D-glucopyranose derivatives and use thereof
Read more01 Apr 2008
publication
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position
Read more01 Jan 2007
publication
[Carbohydrates and vaccines: from purified polysaccharides to semi-synthetic glycoconjugate vaccines]
Read more01 Feb 2006
publication
Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
Read more26 Oct 2005
publication
Toward a better understanding of the basis of the molecular mimicry of polysaccharide antigens by peptides: the example of Shigella flexneri 5a
Read more01 Sep 2005
publication
On the preparation of carbohydrate-protein conjugates using the traceless Staudinger ligation
Read more19 Apr 2005
publication
Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues
Read more18 Feb 2005
publication
Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection
Read more01 Jan 2005
publication
Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance
Read more17 Nov 2004
publication
Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs
Read more20 Jun 2004
publication
Total synthesis of a tetra- and two pentasaccharide fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a
Read more19 May 2004
publication
A structural basis for the inhibition of the NS5 dengue virus mRNA 2′-O-methyltransferase domain by ribavirin 5′-triphosphate
Read more26 Apr 2004
publication
Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease
Read more20 Feb 2004
publication
Blockwise approach to fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a: convergent Synthesis of a decasaccharide representative of a dimer of the branched repeating unit
Read more18 Aug 2003
publication
Conformational studies of the O-specific polysaccharide of Shigella flexneri 5a and of four related synthetic pentasaccharide fragments using NMR and molecular modeling
Read more01 Mar 2003
publication
Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets
Read more16 Oct 2002
publication
Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen
Read more08 Aug 2002
publication
Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation
Read more09 Jul 2002
publication
Convergent synthesis, NMR and conformational analysis of tetra- and pentasaccharide haptens of the Shigella flexneri 5a O-specific polysaccharide
Read more19 Feb 2002
publication
Synthesis and NMR study of a linear pentasaccharide fragment of the Shigella flexneri 5a O-specific polysaccharide
Read more01 Jan 2002
01 Nov 2001
publication
Conformation of the O-specific polysaccharide of Shigella dysenteriae type 1: molecular modeling shows a helical structure with efficient exposure of the antigenic determinant alpha-L-Rhap-(1–>2)-alpha-D-Galp
Read more08 Aug 2001
publication
MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis
Read more01 Apr 2001
publication
Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: improvement by alpha-boranophosphate substitution
Read more27 Dec 2000
publication
The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance
Read more27 Sep 2000
publication
Linear synthesis of the methyl glycosides of tetra- and pentasaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen
Read more01 Jan 2000
publication
Linear synthesis of the methyl glycosides of tri-, tetra-, and pentasaccharide fragments of the Shigella flexneri serotype 5a O-antigen
Read more01 Jan 2000
publication
Synthesis of the methyl glycosides of a di- and two trisaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen
Read more01 Jan 2000
publication
First synthesis of a branched pentasaccharide representative of the repeating unit of the Shigella flexneri serotype 5a O-antigen
Read more01 Sep 1999
publication
Immunochemical characterization of an Ogawa-Inaba common antigenic determinant of Vibrio cholerae O1
Read more01 Jan 1999
publication
Synthesis of the methyl glycosides of a tri- and tetrasaccharide fragment specific for the Shigella flexneri serotype 5a O-antigen. A reinvestigation
Read more01 Sep 1998
publication
Synthesis of tri- and tetrasaccharide fragments of the Shigella dysenteriae type 1 O-antigen deoxygenated and fluorinated at position 3 of the methyl alpha-D-galactopyranoside terminus
Read more01 Jul 1998
publication
Binding of modified fragments of the Shigella dysenteriae type 1 O-specific polysaccharide to monoclonal IgM 3707 E9 and docking of the immunodeterminant to its modeled Fv
Read more01 Jan 1997
publication
Investigation by NMR spectroscopy and molecular modeling of the conformations of some modified disaccharide antigens for Shigella dysenteriae type 1
Read more01 Sep 1995
publication
Synthesis of specifically deoxygenated disaccharide derivatives of the Shigella dysenteriae type 1 O-antigen
Read more01 Jun 1994
publication
Synthesis of specifically monofluorinated ligands related to the O-polysaccharide of Shigella dysenteriae type 1
Read more01 Jun 1994
01 Jan 1994
publication
Synthesis of methyl O-alpha-L-rhamnopyranosyl-(1–>2)-alpha-D-galactopyranosides specifically deoxygenated at position 3, 4, or 6 of the galactose residue
Read more01 Jan 1993
publication