Timeline

Laurence Mulard
Head of Structure
20 Nov 2023
publication

Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose

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27 Apr 2022
publication

The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella.

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07 Mar 2022
publication

Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella: State-of-the-Art for a Monovalent Prototype and Challenges.

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01 Feb 2022
publication

Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans.

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13 Oct 2021
publication

Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides.

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15 Jul 2021
publication

Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide

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01 Apr 2021
publication

Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study.

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26 Mar 2021
publication

Exploratory N-Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides.

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05 Feb 2021
publication

Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O-Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core.

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28 Jan 2021
publication

Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens.

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01 Jan 2019
publication

Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human.

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01 Dec 2018
publication

ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri.

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25 Aug 2018
project

GlycoShig1

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25 Aug 2018
patent

Protected tetrasaccharides, their preparation and their use in the synthesis of bacterial oligosaccharides

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25 Aug 2018
patent

Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri (SF6)

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25 Aug 2018
patent

Glycoconjugates and use thereof as vaccines against Shigella flexneri serotype 3a and X

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25 Aug 2018
patent

Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri

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15 Aug 2018
publication

Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens.

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24 Mar 2017
publication

Dirhamnolipids secreted from Pseudomonas aeruginosa modify anjpegungal susceptibility of Aspergillus fumigatus by inhibiting β1,3 glucan synthase activity.

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04 Jul 2016
publication

Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a

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01 Jul 2016
publication

Efficient Iterative Synthesis of O-Acetylated Tri- to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di- and Trisaccharide Glycosyl Donors.

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07 Jun 2016
team

Group: Carbohydrates and Bioconjugates

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27 Mar 2016
project

A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial

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27 Mar 2016
project

FlexBiVac

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21 Mar 2016
publication

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

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12 Sep 2015
project

CarbUniVax

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04 Sep 2015
publication

Investigation on the synthesis of Shigella flexneri-specific oligosaccharides using disaccharides as potential transglucosylase acceptor substrates

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08 Jul 2015
project

Synthesis of peptide and protein conjugates towards novel therapeutics and/or diagnostic tools

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03 Jul 2015
project

Carbohydrates as targets of immunity: their synthesis, antibody recognition and use as key vaccine components

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11 May 2015
team

Chemistry of Biomolecules

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14 Feb 2015
publication

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

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07 Jan 2015
publication

Computer-aided design of sequence libraries for the engineering of transglucosylase binding subsites to enable glucosylation of an unnatural disaccharide motif of relevance for bacterial antigen synthesis

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11 Sep 2014
publication

Synthesis of the zwitterionic repeating unit of the O-antigen from Shigella sonnei and chain elongation at both ends

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21 Aug 2014
publication

Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation

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28 Jun 2014
publication

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

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20 Dec 2013
publication

CGTase-catalysed cis-glucosylation of L-rhamnosides for the preparation of Shigella flexneri 2a and 3a haptens

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11 Oct 2013
publication

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxydation

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08 May 2013
publication

Structural studies of the O-acetyl containing O-antigen from a Shigella flexneri serotype 6 strain and synthesis of oligosaccharide fragments thereof

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30 Oct 2012
publication

Applying pairwise combinations of amino acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides

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16 Mar 2012
publication

Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain

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01 Jan 2012
publication

Multidisciplinary approaches to study O-antigen:antibody recognition in support of the development of synthetic carbohydrate-based enteric vaccines

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24 May 2011
publication

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance

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28 Oct 2010
publication

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy

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22 Jul 2010
publication

A pH-based high-throughput screening of sucrose-utilizing transglucosidases for the development of novel enzymatic glucosylation tools

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23 Jul 2009
publication

From epitope characterization to the design of semi-synthetic glycoconjugate vaccines against Shigella flexneri 2a infection

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24 Jun 2009
publication

Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

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01 Jun 2009
publication

Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides

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01 Apr 2009
publication

Efficient synthesis of six tri- to hexasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigen, including a study on acceptors containing N-trichloroacetylglucosamine versus N-acetylglucosamine

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27 Mar 2009
publication

Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a

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01 Mar 2009
publication

Synthesis of L-rhamnose and N-acetyl-D-glucosamine derivatives with glucansucrases

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15 Feb 2009
publication

A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection

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13 Oct 2008
publication

Synthesis of 2 tetra- and 4 pentasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigens from a common tetrasaccharide intermediate

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03 Sep 2008
publication

Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens

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23 Jul 2008
publication

Investigation towards bivalent chemically defined glycoconjugate immunogens prepared from acid-detoxified lipopolysaccharide of Vibrio cholerae O1, serotype Inaba

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10 Jul 2008
publication

Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?

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10 Jul 2008
publication

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody

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15 Jun 2008
publication

Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted--D-glucopyranose derivatives and use thereof

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01 Apr 2008
publication

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position

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01 Jan 2007
publication

[Carbohydrates and vaccines: from purified polysaccharides to semi-synthetic glycoconjugate vaccines]

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01 Feb 2006
publication

Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine

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26 Oct 2005
publication

Toward a better understanding of the basis of the molecular mimicry of polysaccharide antigens by peptides: the example of Shigella flexneri 5a

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01 Sep 2005
publication

On the preparation of carbohydrate-protein conjugates using the traceless Staudinger ligation

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19 Apr 2005
publication

Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues

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18 Feb 2005
publication

Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection

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01 Jan 2005
publication

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

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17 Nov 2004
publication

Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs

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20 Jun 2004
publication

Total synthesis of a tetra- and two pentasaccharide fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a

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19 May 2004
publication

A structural basis for the inhibition of the NS5 dengue virus mRNA 2′-O-methyltransferase domain by ribavirin 5′-triphosphate

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26 Apr 2004
publication

Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease

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20 Feb 2004
publication

Blockwise approach to fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a: convergent Synthesis of a decasaccharide representative of a dimer of the branched repeating unit

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18 Aug 2003
publication

Conformational studies of the O-specific polysaccharide of Shigella flexneri 5a and of four related synthetic pentasaccharide fragments using NMR and molecular modeling

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01 Mar 2003
publication

Structural analysis of the activation of ribavirin analogs by NDP kinase: comparison with other ribavirin targets

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16 Oct 2002
publication

Synthesis of the methyl glycoside of a branched octasaccharide fragment specific for the Shigella flexneri serotype 2a O-antigen

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08 Aug 2002
publication

Improving nucleoside diphosphate kinase for antiviral nucleotide analogs activation

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09 Jul 2002
publication

Convergent synthesis, NMR and conformational analysis of tetra- and pentasaccharide haptens of the Shigella flexneri 5a O-specific polysaccharide

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19 Feb 2002
publication

Synthesis and NMR study of a linear pentasaccharide fragment of the Shigella flexneri 5a O-specific polysaccharide

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01 Jan 2002
publication

Vaccins polysaccharidiques

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01 Nov 2001
publication

Conformation of the O-specific polysaccharide of Shigella dysenteriae type 1: molecular modeling shows a helical structure with efficient exposure of the antigenic determinant alpha-L-Rhap-(1–>2)-alpha-D-Galp

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08 Aug 2001
publication

MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis

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01 Apr 2001
publication

Activation of anti-reverse transcriptase nucleotide analogs by nucleoside diphosphate kinase: improvement by alpha-boranophosphate substitution

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27 Dec 2000
publication

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance

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27 Sep 2000
publication

Linear synthesis of the methyl glycosides of tetra- and pentasaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen

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01 Jan 2000
publication

Linear synthesis of the methyl glycosides of tri-, tetra-, and pentasaccharide fragments of the Shigella flexneri serotype 5a O-antigen

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01 Jan 2000
publication

Synthesis of the methyl glycosides of a di- and two trisaccharide fragments specific for the Shigella flexneri serotype 2a O-antigen

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01 Jan 2000
publication

First synthesis of a branched pentasaccharide representative of the repeating unit of the Shigella flexneri serotype 5a O-antigen

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01 Sep 1999
publication

Immunochemical characterization of an Ogawa-Inaba common antigenic determinant of Vibrio cholerae O1

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01 Jan 1999
publication

Synthesis of the methyl glycosides of a tri- and tetrasaccharide fragment specific for the Shigella flexneri serotype 5a O-antigen. A reinvestigation

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01 Sep 1998
publication

Synthesis of tri- and tetrasaccharide fragments of the Shigella dysenteriae type 1 O-antigen deoxygenated and fluorinated at position 3 of the methyl alpha-D-galactopyranoside terminus

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01 Jul 1998
publication

Binding of modified fragments of the Shigella dysenteriae type 1 O-specific polysaccharide to monoclonal IgM 3707 E9 and docking of the immunodeterminant to its modeled Fv

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01 Jan 1997
publication

Investigation by NMR spectroscopy and molecular modeling of the conformations of some modified disaccharide antigens for Shigella dysenteriae type 1

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01 Sep 1995
publication

Synthesis of specifically deoxygenated disaccharide derivatives of the Shigella dysenteriae type 1 O-antigen

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01 Jun 1994
publication

Synthesis of specifically monofluorinated ligands related to the O-polysaccharide of Shigella dysenteriae type 1

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01 Jun 1994
publication

Fluorination at position 6 of derivatives of methyl alpha-D-galactopyranoside

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01 Jan 1994
publication

Synthesis of methyl O-alpha-L-rhamnopyranosyl-(1–>2)-alpha-D-galactopyranosides specifically deoxygenated at position 3, 4, or 6 of the galactose residue

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01 Jan 1993
publication

Synthesis of 2′-deoxy-2′-spirocyclopropyl cytidine as potential inhibitor of Ribonucleoside Diphosphate Reductase

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