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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Annales pharmaceutiques françaises

[Carbohydrates and vaccines: from purified polysaccharides to semi-synthetic glycoconjugate vaccines]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales pharmaceutiques françaises - 01 Jan 2007

Mulard L

Link to Pubmed [PMID] – 17299349

Ann Pharm Fr 2007 Jan;65(1):14-32

Over the last decades, capsular polysaccharides have been successfully used as antibacterial vaccines. Marketing several polysaccharide-protein conjugate vaccines filled the gap in many areas of children and infant vaccination. By facilitating access to structures of increasing complexity, recent progress in glycochemistry has enabled the design of more and more precisely defined glycoconjugate vaccines using synthetic saccharide components which mimic epitopes naturally implicated in protection. This strategy was recently validated in humans. It opens the way to new perspectives in vaccine research devoted to prophylactic and/or therapeutic applications against bacterial, fungal, parasitic or viral infections, and certain cancers.

http://www.ncbi.nlm.nih.gov/pubmed/17299349