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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Apr 2016
Ending Date
31
Mar 2018
Status
Ongoing
Members
3
Structures
2

About

Sitting at the frontier between the fields of Chemistry, Glycosciences, and Vaccinology, FlexBiVac is a multidisciplinary project aimed at demonstrating the proof of concept for a new generation of polysaccharide-based multivalent vaccines. 

The concept is tackled for bacillary dysentery, one of the four major diarrheal diseases among children under 5. Killing 800,000 children annually, more than AIDS and malaria combined, diarrheal diseases are the second cause of childhood mortality. The need for a multivalent vaccine against Shigella, the causing agent of bacillary dusentery,  is a critical issue and a roadblock to a licensed vaccine. Regarding Shigella flexneri, the prevalent species, a cocktail of 4 serotypes would cover 80% and possibly up to 90% of all cases.

High chemical similarities amongst the S. flexneri surface polysaccharides and the possible implementation of highly convergent synthetic strategies to fragments thereof  support the use of synthetic functional mimics of these protective antigens for developing a vaccine. The proof of concept was demonstrated for a monovalent synthetic carobohydrate-based vaccine candidate, paving the way towards a powerful “drug-like” multivalent Shigella vaccine.

By combining a monovalent chemically defined glycoconjugate vaccine candidate ready for clinical evaluation  with the most promising glycoconjugates to be identified for other serotypes, FlexBiVac aims at making the proof of concept for a synthetic carbohydrate-based di- and trivalent S. flexneri combinations, essential to move forward to the required vaccine candidate.