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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : European Journal of Chemistry

Synthesis of 2 tetra- and 4 pentasaccharide fragments of Shigella flexneri serotypes 3a and/or X O-antigens from a common tetrasaccharide intermediate

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European Journal of Chemistry - 13 Oct 2008

Boutet J, Mulard LA

Eur. J. Org. Chem. 2008: 5526–5542

Relying on trichloroacetimidate chemistry, six tetra- and pentasaccharide fragments of the {2)-[α-D-Glcp-(13)]-α-L-Rhap-(12)-α-L-Rhap-(13)-[Ac2]-α-L-Rhap-(13)-β-DGlcpNAc-(1}n ((E)ABAcCD)n polymer were synthesized as their propyl glycosides by use of a common fully protected (E)ABAcC intermediate (9). Tetrasaccharide 9 derived from the condensation of an EA donor and a BAcC acceptor. Partial and full deprotection gave free tetrasaccharides (E)ABAcC and (E)ABC, respectively. Alternatively, 9 was converted into a trichloroacetimidate donor, which provided linear pentasaccharides (E)ABAcCD and (E)ABCD, following a reaction with a D acceptor and subsequent partial or total deprotection, respectively. Additionally, the selective removal of the 2A-levulinoyl protecting group in 9 allowed for chain elongation at this position. The glycosylation of the resulting acceptor with a D donor, and subsequent partial or total deprotection, gave branched pentasaccharides D(E)ABAcC and D(E)ABC. All targets are parts of the O-antigen of Shigella flexneri 3a, a prevalent serotype. Non-O-acetylated oligosaccharides are shared by the S. flexneri serotype X O-antigen.