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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Carbohydrate-based vaccines, ACS Symp Ser No. 989

From epitope characterization to the design of semi-synthetic glycoconjugate vaccines against Shigella flexneri 2a infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Carbohydrate-based vaccines, ACS Symp Ser No. 989 - 23 Jul 2009

Mulard LA, Phalipon A

ACS Symp Ser No. 989, R. Roy Ed, American Chemical Society, Washington, DC, USA 2009, pp 105-136

The four-step conception of a potential Shigella flexneri 2a glycoconjugate vaccine exposing synthetic oligosaccharides mimicking the serotype-specific protective determinants is described. (i) Study of the recognition of synthetic O-antigen fragments by protective murine mIgGs showed that the O-antigen exhibits a serotype-specific immunodominant epitope and that chain elongation improves binding. (ii) Five epitope-related tri- to pentadecasaccharides were synthesized and coupled via single point-attachment to tetanus toxoid or PADRE. (iii) The immunogenicity of the conjugates was assessed in mice. (iv) The protective efficacy of sera induced by the most immunogenic conjugates was evaluated in a murine model of pulmonary infection. A pentadecasaccharide was identified as a good candidate for further development of a S. flexneri 2a semi-synthetic glycoconjugate vaccine.