The regulatory network of sporulation and spore morphogenesis in Clostridium difficile
Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]
Drug Discovery & Screening at Institut Pasteur
The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]
2018Discovery of new type I toxin-antitoxin systems adjacent to CRISPR arrays in Clostridium difficile, Nucleic Acids Res. 2018 May;46(9):4733-4751.
2017The alternative sigma factor σ plays a crucial role in adaptive strategies of Clostridium difficile during gut infection, Environ. Microbiol. 2017 May;19(5):1933-1958.
2016A Recombination Directionality Factor Controls the Cell Type-Specific Activation of σK and the Fidelity of Spore Development in Clostridium difficile, PLoS Genet. 2016 Sep;12(9):e1006312.
2014The regulatory network controlling spore formation in Clostridium difficile, FEMS Microbiol. Lett. 2014 Sep;358(1):1-10.
2014Pleiotropic role of the RNA chaperone protein Hfq in the human pathogen Clostridium difficile, J. Bacteriol. 2014 Sep;196(18):3234-48.
2014Riboswitch discovery by combining RNA-seq and genome-wide identification of transcriptional start sites, Meth. Enzymol. 2014;549:3-27.
2013Genome-wide analysis of cell type-specific gene transcription during spore formation in Clostridium difficile, PLoS Genet. 2013;9(10):e1003756.
2013Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile, PLoS Genet. 2013 May;9(5):e1003493.
2012PlcRa, a new quorum-sensing regulator from Bacillus cereus, plays a role in oxidative stress responses and cysteine metabolism in stationary phase, PLoS ONE 2012;7(12):e51047.
2012Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile, Nucleic Acids Res. 2012 Nov;40(21):10701-18.
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