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About

The Innate Immunity Unit comprises 18 members (4 permanent scientists, 4 engineers/technicians, 5 postdoctoral fellows, 5 PhD students) with complementary interests and expertise in immunology, developmental biology, virology and animal models. Together with the Lymphocytes and Immunity Unit (Ana Cumano), Dynamics of Immune Response Unit (Philippe Bousso) and Genome Integrity, Immunity and Cancer Unit (Ludovic Deriano), we form the Inserm Unit 1223 (Pathophysiology of the Immune System) that pursues collaborative projects involving lymphocyte development, differentiation and functional dynamics in mouse and man.

Members

James Di Santo
Head of Structure
Head
Hélène Strick-Marchand
Group Leader
Christian Vosshenrich
Group Leader
Nicolas Serafini
Permanent Researcher
Jean-Marc Doisne
Research Engineer
Pedro Goncalves
Post-doc
Laura Surace
Post-doc
Marie Solenne
Research Engineer
Angèle Schiavo
Technician
Danièle Sinnaya
Administrative Staff
Angélique Jarade
PhD Student
Carys Croft
PhD Student
Toshiki Eri
Post-doc
Giulia Girelli-Zubani
Post-doc
Anna Thaller
PhD Student
Evgeny Tatirovsky
PhD Student
Thibault Leray
Master Student
Remy Dailleux
Technician
Elsa Bourayou
Post-doc

Former Members

2000
2000
Name
Position
1999
2017
Cecile Pham
Administrative Assistant
1999
2012
Erwan Corcuff
Research Engineer
1999
2009
Odile Richard
Technician
1999
2004
Francesco Colucci
Permanent Researcher
1999
2001
Soren Bregenholt
Post-doc
1999
2001
Eleftheria Rosmaraki
PhD Student
2000
2003
Sandrine Samson
PhD Student
2001
2004
Thomas Ranson
PhD Student
2001
2001
Karine Le Barillec
Post-doc
2002
2004
Simona Zompi
PhD Student
2003
2006
Marcos Garcia-Ojeda
Post-doc
2003
2006
Guillemette Masse
PhD Student
2003
2005
Anouk Caraux
PhD Student
2004
2005
Loredana Cifaldi
Post-doc
2005
2008
Milena Hasan
Post-doc
2006
2011
Nicholas Huntington
Post-doc
2007
2011
Naoko Satoh
Post-doc
2007
2010
Nuno Alves
Post-doc
2007
2009
Helene Decaluwe
PhD Student
2007
2008
Moshe Elkabets
Post-doc
2008
2010
Jean-Jacques Mention
Post-doc
2008
2010
Abdessalem Rekiki
Post-doc
2008
2010
Vera Ribiero
PhD Student
2009
2010
Aurélie Olivier
Post-doc
2010
2011
Georges Azar
Post-doc
2011
2015
Wei Xu
Post-doc
2011
2013
Nathalie Court
Post-doc
2011
2013
Leila Ben-Merzoug
PhD Student
2011
2013
Roel Klein-Wolterink
PhD Student
2012
2017
Yan Li
Post-doc
2012
2014
Naoko Satoh-Takayama
Permanent Researcher
2012
2014
Mathilde Dusséaux
Post-doc
2013
2019
Guillemette Masse-Ranson
Post-doc
2013
2016
Thomas Verrier
PhD Student
2014
2017
Silvia Lopez-Lastra
PhD Student
2014
2017
Ai Ing Lim
PhD Student
2015
2018
Wenjuan Jiao
PhD Student
2015
2017
Giorgia Benigni
Post-doc
2016
2020
Dylan Cherrier
PhD Student
2016
2019
Armanda Casrouge
Research Engineer
2017
2020
Magali Dupont
PhD Student
Show all

Courses

09:00
09
Jan 2024
Course

Innate Immunity MOOC

This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens. Register on : https://www.fun-mooc.fr/en/courses/innate-immunity/ Description: More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity […]
Innate Immunity
Jean-Marc Cavaillon
Daniel Scott-Algara
Ségolène Gracias
2024-01-09 09:00:00 2024-03-13 23:00:00 Europe/Paris Innate Immunity MOOC This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens. Register on : https://www.fun-mooc.fr/en/courses/innate-immunity/ Description: More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity […]
09:00
02
Dec 2018
Course

10th HKU-Pasteur Immunology Course: December 2-15, 2018

  ‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […]
Innate Immunity
UTechS Single Cell Biomarkers
LabEx Milieu Intérieur
Hong Kong University-Pasteur Research Pole
Immunology
James Di Santo
Milena Hasan
Darragh Duffy
Tineke Cantaert
2018-12-02 09:00:00 2018-12-15 18:00:00 Europe/Paris 10th HKU-Pasteur Immunology Course: December 2-15, 2018   ‘Quantitative Immunology’ will be the theme of the 10th anniversary of the HKU-Pasteur Immunology Course. We will explore the ongoing transition from reductionist studies, based on the application of genetic approaches in animal models, […] HKU-Pasteur Research Centre, Hong Kong

Projects

Project
Ongoing
5 Members

Modeling SARS-CoV-2 infection and immune responses in humanized mouse models

Hélène Strick-Marchand (PI)
Project
Ongoing
9 Members

Deci VERNEUIL – Etiology of Hidradenitis Suppurativa

Caroline Demangel (PI)

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Project
Ongoing
7 Members

ERC-2015-AdG ILC_REACTIVITY

James Di Santo (PI)

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Project
Ongoing
6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Project
Ongoing
8 Members

Mouse Model to Understand Innate Lymphoid Cell Biology

James Di Santo (PI)

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
Project
Ongoing
3 Members

Pathogen co-infection : HIV, TB, Malaria and HCV

James Di Santo (PI)

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Project
Ongoing
5 Members

Host responses to microbial intestinal invasion, impact on microbial dissemination

Marc Lecuit (PI)

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Project
ongoing
1 Member

A novel mouse model for conditional gene targeting

James Di Santo (PI)

Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]

Transversal Project

Array

The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]

Drug Discovery & Screening at Institut Pasteur

The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]

Vaccinology and Immunotherapy initiative

Vaccines have had a major positive impact on public health world-wide through disease prevention that can be measured in millions of lives saved. Despite the successes, we still face major challenges in vaccine and […]

Cancer Initiative

With more than 19.3 million new cases in 2020 worldwide, including nearly 400,000 in France, cancer is a common disease that affects or will affect us all one day, directly or indirectly. It is […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception aims to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in various health issues (Official website here: https://www.inception-program.fr/en). The inception program uses Integrative Biology, […]

The Healthy Human Global Project

Susceptibility to infections, disease progression and severity, and response to medical therapies and vaccines are highly variable from one individual to another. The complexity of individual immune responses is such that it has not […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. The Milieu Intérieur Project While the immune […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Fundings

Publications

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Contact

Phone: 014568209 Email: james.di-santo@pasteur.fr Address 25-28 Rue du Docteur Roux