PIBnet – Pasteur International Bioresources network
The PIBnet program aims at harmonizing microbial strain biobanking and analytical methods deployed within the microbiological expertise laboratories in Paris and throughout the International Network of Institut Pasteur. It is a large collaborative program […]
Expanding the toolbox for genetic manipulation of Leptospira spp.
In comparison to other bacterial species, genetics and molecular basis of the pathogenesis of leptospires are in their infancy. An improved understanding of leptospiral pathogenesis requires reliable genetic tools for functional genetic analysis of […]
Phenotypic characterization of transposon mutants in the pathogen L. interrogans
Site-directed homologous recombination has not been successful in pathogenic Leptospira and there exist only a few examples of mutants obtained by targeted mutagenesis. We have generated a library of random mutants in the pathogen […]
Cell morphology, chemotaxis, and motility in Leptospira spp.
Leptospira spp. are thin, highly motile, slow-growing spirochetes that can be distinguished from other bacteria on the basis of their unique helical shape and the presence of periplasmic flagella. We showed that peptidoglycan sacculi […]
Signal transduction and regulation of gene expression in Leptospira
We previously demonstrated that the inactivation of a two-component system (TCS), called HemK/HemR, results in heme auxotrophy in the saprophyte L. biflexa. In L. interrogans, the hemK and hemR orthologous genes are located within […]
Exoproteins and Leucin-Rich Repeat (LRR) proteins in Leptospira spp.
The roles of leptospiral exoproteins in the mechanisms of disease manifestation in the host have not been determined. We assessed the composition and quantity of exoproteins of pathogenic L. interrogans and their contribution to […]
Development and evaluation of rapid diagnostic tests on leptospirosis
Early laboratory diagnosis of leptospirosis is important to provide appropriate treatment of patients and to take rapid measures in case of an outbreak. Unfortunately, few tests possess both high sensitivity and specificity; this is […]
Molecular and serological investigations on leptospirosis
The genus Leptospira includes 21 Leptospira species, including L. mayottensis (see below), and more than 300 serovars have been described. Little is known about the circulating etiological agents of leptospirosis in most of the […]
2018Leptospirosis as Cause of Febrile Icteric Illness, Burkina Faso, Emerging Infect. Dis. 2018 Aug;24(8):1569-1572.
2018Genomic Comparison Among Global Isolates of Serovars Copenhageni and Icterohaemorrhagiae Identified Natural Genetic Variation Caused by an Indel, Front Cell Infect Microbiol 2018;8:193.
2018FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete, Front Cell Infect Microbiol 2018;8:130.
2018Biodiversity of Environmental : Improving Identification and Revisiting the Diagnosis, Front Microbiol 2018;9:816.
2018The sigma factor σ is required for the long-term survival of Leptospira biflexa in water, Mol. Microbiol. 2018 Apr;.
2018Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic, Front Cell Infect Microbiol 2018;8:45.
2018Deciphering the unexplored Leptospira diversity from soils uncovers genomic evolution to virulence, Microb Genom 2018 Jan;.
2018Antibiotic susceptibilities of livestock isolates of leptospira, Int. J. Antimicrob. Agents 2018 Jan;.
2017Leptospira venezuelensis sp. nov., a new member of the intermediate group isolated from rodents, cattle and humans, Int. J. Syst. Evol. Microbiol. 2017 Dec;.
2017LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition, PLoS Pathog. 2017 12;13(12):e1006725.
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