PIBnet – Pasteur International Bioresources network
The PIBnet program aims at harmonizing microbial strain biobanking and analytical methods deployed within the microbiological expertise laboratories in Paris and throughout the International Network of Institut Pasteur. It is a large collaborative program […]
Expanding the toolbox for genetic manipulation of Leptospira spp.
In comparison to other bacterial species, genetics and molecular basis of the pathogenesis of leptospires are in their infancy. An improved understanding of leptospiral pathogenesis requires reliable genetic tools for functional genetic analysis of […]
Phenotypic characterization of transposon mutants in the pathogen L. interrogans
Site-directed homologous recombination has not been successful in pathogenic Leptospira and there exist only a few examples of mutants obtained by targeted mutagenesis. We have generated a library of random mutants in the pathogen […]
Cell morphology and motility in Leptospira spp.
Leptospira spp. are thin, highly motile, slow-growing spirochetes that can be distinguished from other bacteria on the basis of their unique helical shape and the presence of periplasmic flagella. We showed that peptidoglycan sacculi […]
Exoproteins and Leucin-Rich Repeat (LRR) proteins in Leptospira spp.
The roles of leptospiral exoproteins in the mechanisms of disease manifestation in the host have not been determined. We assessed the composition and quantity of exoproteins of pathogenic L. interrogans and their contribution to […]
Development and evaluation of rapid diagnostic tests on leptospirosis
Early laboratory diagnosis of leptospirosis is important to provide appropriate treatment of patients and to take rapid measures in case of an outbreak. Unfortunately, few tests possess both high sensitivity and specificity; this is […]
Molecular and serological investigations on leptospirosis
The genus Leptospira includes 35 Leptospira species, including L. mayottensis (see below), and more than 300 serovars have been described. Little is known about the circulating etiological agents of leptospirosis in most of the […]
20204-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans., Nucleic Acids Res 2020 Dec; 48(21): 12102-12115.
2020Toolbox of Molecular Techniques for Studying Leptospira Spp., Curr Top Microbiol Immunol ; 415(): 141-162.
2020The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress., PLoS Pathog 2020 Oct; 16(10): e1008904.
2020Circulating genotypes of Leptospira in French Polynesia : An 9-year molecular epidemiology surveillance follow-up study., PLoS Negl Trop Dis 2020 09; 14(9): e0008662.
2020Correction: Genus-wide Leptospira core genome multilocus sequence typing for strain taxonomy and global surveillance., PLoS Negl Trop Dis 2020 08; 14(8): e0008673.
2020First report of human Leptospira santarosai infection in French Guiana., J Infect Public Health 2020 Aug; 13(8): 1181-1183.
2020Isolation of Leptospira interrogans from a Bottlenose Dolphin (Tursiops truncatus) in the Mediterranean Sea., J. Wildl. Dis. 2020 07; 56(3): 727-729.
2020The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production., NPJ Biofilms Microbiomes 2020 06; 6(1): 24.
2020An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete., Elife 2020 Mar; 9(): .
2020Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella., Front Immunol 2020 ; 11(): 2007.
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