Jost studied biochemistry at the University of Hannover and at the Medical School of Hannover (MHH), in Germany. For his Masters thesis and his Ph.D. studies, he joined the Laboratory of Cell Biology at the Rockefeller University, New York City, where he focused on the transport of biological macromolecules between cellular compartments using cell biological approaches. Afterwards, Jost wanted to apply his cell biological knowledge to the investigation of host-pathogen interactions. So in spring 2004 he came to the Institut Pasteur, Paris, to work with Guy Tran Van Nhieu and Philippe Sansonetti on the secretion of type III effectors from Gram negative bacteria. At the beginning of 2008, Jost went on searching for new adventures, so he started his own independent research team in the department of Cell Biology and Infection at the Institut Pasteur in Paris.
Microscopy – Principles and Applications of Fluorescence Microscopy
Fluorescence microscopy has revolutionized researchers’ ability to monitor cellular structures and dynamics. Over the last decades, the spectrum of applications of fluorescence microscopy has been constantly broadened by novel combinations of optics principles supported […]
INCEPTION – INstitut Convergences pour l’étude de l’Émergence des Pathologies au Travers des Individus et des populatiONs et des
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Le programme de biologie quantitative de l’Institut Pasteur est destiné à faciliter la recherche et l’éducation à l’interface entre la biologie et les sciences plus quantitatives. L’un des principaux objectifs de la biologie quantitative […]
Milieu Intérieur [LabEx]
Qu’est-ce que le projet Milieu Intérieur ? Le projet Milieu Intérieur est l’un des lauréats de la première vague d’appel d’offre “Laboratoire d’Excellence”. Le projet Milieu Intérieur réunit l’expertise multidisciplinaire de chercheurs dans les […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation Le but du projet Biologie Intégrative des Maladies Infectieuses Emergentes (IBEID), coordonné par les professeurs Philippe Sansonetti et Pascale Cossart, est de développer une structure pour anticiper et lutter contre les maladies […]
Detection and countermeasures against bacterial toxins
Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]
ANR 2015 AutoHostPath
Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major […]
A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular […]
Infectious diseases are a major public health problem, and identification of novel potentialtherapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their current […]
Dual microscopy assay to discriminate Listeria cellular entry & vacuolar escape
We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]
2020Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection, Cell Rep 2020 May;31(6):107638.
2020Transcytosis subversion by M cell-to-enterocyte spread promotes Shigella flexneri and Listeria monocytogenes intracellular bacterial dissemination, PLoS Pathog. 2020 Apr;16(4):e1008446.
2020The actin comet guides the way: How Listeria actin subversion has impacted cell biology, infection biology and structural biology, Cell. Microbiol. 2020 Apr;22(4):e13190.
2019Dynamic Growth and Shrinkage of the Salmonella-Containing Vacuole Determines the Intracellular Pathogen Niche, Cell Rep 2019 Dec;29(12):3958-3973.e7.
2019The best of both worlds- bringing together cell biology and infection at the Institut Pasteur, Microbes Infect. 2019 Jun - Jul;21(5-6):254-262.
2019The best of both worlds-bringing together cell biology and infection at the Institut Pasteur, Genes Immun. 2019 May;20(5):426-435.
2019Cellular Imaging of Intracellular Bacterial Pathogens, Microbiol Spectr 2019 03;7(2).
2018The Pathogen-Host Interface in Three Dimensions: Correlative FIB/SEM Applications, Trends Microbiol. 2018 Dec;.
2018High-throughput Microscopic Analysis of Invasion of Host Cells, Bio Protoc 2018 Sep;8(18).
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 07;10(1):59.
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