Jost studied biochemistry at the University of Hannover and at the Medical School of Hannover (MHH), in Germany. For his Masters thesis and his Ph.D. studies, he joined the Laboratory of Cell Biology at the Rockefeller University, New York City, where he focused on the transport of biological macromolecules between cellular compartments using cell biological approaches. Afterwards, Jost wanted to apply his cell biological knowledge to the investigation of host-pathogen interactions. So in spring 2004 he came to the Institut Pasteur, Paris, to work with Guy Tran Van Nhieu and Philippe Sansonetti on the secretion of type III effectors from Gram negative bacteria. At the beginning of 2008, Jost went on searching for new adventures, so he started his own independent research team in the department of Cell Biology and Infection at the Institut Pasteur in Paris.
Principles and Applications of fluorescence Microscopy
Together with David DiGregorio and Gael Moneron (both members of the Neuroscience department) we organize a course of Advanced Imaging entitled “Principles and Applications of fluorescence Microscopy”. This event is propose for Master and […]
ANR 2015 AutoHostPath
Understanding the molecular basis of host-pathogen interactions is critical for the discovery of new therapeutic approaches to treat infectious diseases, which in the face of increasing antibiotic resistance and emerging pathogens, is a major […]
A common strategy of bacterial pathogens is active or passive uptake into host cells. There, they can localize within a bacterial containing vacuole (BCV) or access the host cytoplasm through BCV rupture. Hence, intracellular […]
Infectious diseases are a major public health problem, and identification of novel potentialtherapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their current […]
Dual microscopy assay to discriminate Listeria cellular entry & vacuolar escape
We developed a novel image-based microscopy assay which allows to discriminate Listeria monocytogenes cellular entry from vacuolar escape, enabling high-content screening to identify factors specifically involved in these two steps. We generated a L. […]
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines, Genome Med 2018 07;10(1):59.
2018Mitochondrial reactive oxygen species regulate the induction of CD8 T cells by plasmacytoid dendritic cells, Nat Commun 2018 Jun;9(1):2241.
2018Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors, Nat. Immunol. 2018 Mar;19(3):302-314.
2018Parallel derivation of isogenic human primed and naive induced pluripotent stem cells, Nat Commun 2018 01;9(1):360.
2017Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(3):E488-E497.
2017The entry of Salmonella in a distinct tight compartment revealed at high temporal and ultrastructural resolution, Cell. Microbiol. 2018 Apr;20(4).
2017Identifying parameters of host cell vulnerability during Salmonella infection by quantitative image analysis and modeling, Infect. Immun. 2017 Oct;.
2017Shigella Stays on the Move, Cell Host Microbe 2017 Oct;22(4):432-433.
2017The Shigella type III effector IpgD recodes Ca(2+) signals during invasion of epithelial cells, EMBO J. 2017 Sep;36(17):2567-2580.
2017Imaging macropinosomes during Shigella infections, Methods 2017 May;.
+Voir la liste complète de publications