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  • Director of Center
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About

The goal of our team is to understand the molecular mechanisms of protein transport and organelle biogenesis using Gram-negative bacteria such as Escherichia coli and Klebsiella as model organisms.  We are focusing on basic mechanisms of protein transport via the Type 2 secretion system and assembly of surface filaments called Type 4 pili.  Both of these complex nanomachines share similar protein components and assemble flexible filaments from membrane protein subunits. In Type 2 secretion system, these filaments (pseudopili) promote secretion of fully folded proteins from the intermembrane space – the periplasm across the bacterial outer membrane. Type 4 pili in Enterohemorhagic Escherichia coli (EHEC) are implicated in bacterial adhesion to surfaces, DNA uptake  and natural competence.

We integrate genetic, biochemical and functional analyses with structural, biophysical and modeling approaches to reach detailed mechanistic view of these dynamic macromolecular systems spanning the bacterial envelope. Mechanistic studies of these systems lead to more basic questions in protein science, touching upon protein-protein and protein-membrane interactions, protein folding, localization, quality control and turnover.

Former Members

2000
2000
Name
Position
2006
2010
Manuel Campos
M2 and PhD student
2008
2011
David A. Cisneros
Post-doc
2010
2014
Mangayarkarasi Nivaskumar
PhD student PPU program
2009
2014
Gerard H. M. Huysmans
Post-doc
2011
2012
Cedric Bernarde
Post-doc
2014
2016
Javier Santos Moreno
PhD Student
2005
2016
Nathalie Nadeau
Technician
2015
2016
Martine Belin
Administrative Staff
2014
2018
Areli Luna-Rico
PhD Student PPU program
2015
2020
Iva Sucec
M2 student Erasmus program
2015
2020
Nicolas Bayan
Visiting professor
2015
2019
Jenny Lee Thomassin
Post-doc
2018
2019
Andrea Ori
M2 student Fulbright fellow
2013
2013
Denise Leyton
Visiting scientist
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Projects

Transversal Project

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Featured publications

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Olivera Francetic, bacterial protein transport

Contact

Phone: 01 40 61 36 81
Email: ofrancet@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris CEDEX 15
France