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© Sandrine Etienne-Manneville
Photo prise à l'avant (dans la protrusion) d'astrocytes primaires de rat en migration. Marquage par immunofluorescence montrant en rouge, p150 Glued, une protéine associée aux extrémités 'plus' des microtubules et en vert la tubuline des microtubules. La photographie montre l'accumulation de p150 Glued à l'avant des cellules en migration, où la protéine pourrait participer à l'ancrage des microtubules à la membrane plasmique. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaires.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
26
Jan 2018
Ending Date
31
Jan 2020
Status
Ongoing
Members
3
Structures
1

About

 

Other research projects are aimed at exploring the regulatory role of different nucleotides such ppGpp and pppGpp that are both thought to act as second messengers in many complex cellular responses to nutritional stress (Mechold et al., 2013), or of 3’-5’phosphoadenosine phosphate (pAp), a by-product of sulfur and lipid metabolism. We recently identified the Poly(ADP-ribose) Polymerase 1 (PARP-1), a key enzyme in the detection of DNA single strand breaks as a novel target of pAp (Toledano et al., 2012).  We are also interested in the Exoenzyme Y (ExoY) virulence factor from Pseudomonas aeruginosa, a pathogen causing nosocomial infections in human. ExoY is a bacterial nucleotidyl cyclase that is injected by a type III secretion system into host cells where it is activated by an eukaryotic cofactor that we recently identified. ExoY produces a variety of cyclic nucleotides, cAMP, cGMP, cUMP in the infected host cells (Beckert et al. 2014). Their precise contributions to the pathogenicity of P. aeruginosa, remain to be clarified.