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Regulatory roles of signaling Nucleotides
Undine Mechold (PI)
Other research projects are aimed at exploring the regulatory role of different nucleotides such ppGpp and pppGpp that are both thought to act as second messengers in many complex cellular responses to nutritional […]
2021Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens., Nat Commun 2021 11; 12(1): 6628.
2018Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin, PLoS ONE 2018;13(11):e0206133.
2018The extreme C terminus of the effector ExoY is crucial for binding to its eukaryotic activator, F-actin, J. Biol. Chem. 2018 12;293(51):19785-19796.
2017ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview, Toxicon 2018 Jul;149:65-71.
2016Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins, Nat Commun 2016 Dec;7:13582.
2015Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. U.S.A. 2015 Aug;.
2014Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis, PLoS ONE 2014;9(1):e86096.
2013Differential regulation by ppGpp versus pppGpp in Escherichia coli, Nucleic Acids Res. 2013 Jul;41(12):6175-89.
20123′-5′ phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo, Biochem. J. 2012 Apr;443(2):485-90.
2012Identification of a novel nanoRNase in Bartonella, Microbiology (Reading, Engl.) 2012 Apr;158(Pt 4):886-95.
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