Timeline

Paola Arimondo
Head of Structure
24 Sep 2019
project

Targeting Malaria Epigenetics

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17 Sep 2019
event

Department of Structural Biology and Chemistry: Jurgen Brem, Enabling antibiotics to combat multidrug resistant bacteria

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22 Feb 2019
event

Department of Structural Biology and Chemistry: Michaela Frye, RNA methylation in stem cells and cancer

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16 Jan 2019
publication

Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

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02 Jan 2019
publication

Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells

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02 Jan 2019
publication

Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide

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10 Dec 2018
publication

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

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07 Dec 2018
event

Seminar of the Structural Biology and Chemistry department: Dr. Maria Duca

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17 Oct 2018
publication

Identification of novel quinazoline derivatives as potent antiplasmodial agents

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29 Jun 2018
publication

A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy

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05 Jun 2018
publication

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

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05 Jun 2018
publication

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

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05 Jun 2018
publication

The past and presence of gene targeting: from chemicals and DNA via proteins to RNA

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09 Apr 2018
event

“DNA bases beyond Watson & Crick” – Pr. Thomas CARELL

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06 Apr 2018
publication

The DNMT3A R882H mutant displays altered flanking sequence preferences

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03 Apr 2018
event

Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies – Nathaniel I. Martin Phd

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29 Mar 2018
event

Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies

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16 Jan 2018
event

Scientific fraud as an industry – Enrico M. Bucci Phd

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16 Jan 2018
event

Early Career Unvestigators Meeting on Epigenetic Chemical Biology

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15 Jan 2018
publication

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches

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09 Jan 2018
team

Epigenetic Chemical Biology

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10 Aug 2017
publication

Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors

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23 May 2017
publication

Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells

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05 Jan 2017
publication

DNA Methylation Targeting: The DNMT/HMT Crosstalk Challenge

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09 Dec 2016
publication

DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies

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31 Aug 2016
publication

Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells

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15 Mar 2016
publication

Identification and optimization of hydrazone-gallate derivatives as specific inhibitors of DNA methyltransferase 3A

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01 Jan 2016
publication

DNA Methyltransferase Inhibitors: Development and Applications

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10 Jul 2015
publication

Design and synthesis of new non nucleoside inhibitors of DNMT3A

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20 Jun 2015
publication

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2′-deoxycytidine in human leukemic KG1 cells

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23 Jan 2015
publication

Combined analysis of DNA methylation and cell cycle in cancer cells

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01 Jan 2015
publication

DNA Methylation Analysis of ChIP Products at Single Nucleotide Resolution by Pyrosequencing®

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18 Dec 2014
publication

New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors

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04 Dec 2014
publication

Targeting DNA methylation with small molecules: what’s next?

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15 Sep 2014
department

Structural Biology and Chemistry

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26 Aug 2014
publication

Cytisine-like alkaloids from Ormosia hosiei Hemsl. & E.H. Wilson

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01 Jul 2014
publication

Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy

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08 May 2014
publication

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity

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01 Mar 2014
publication

Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation

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03 Feb 2014
publication

Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers

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15 Jan 2014
publication

Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells

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09 Jan 2014
publication

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1

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25 Aug 2013
publication

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

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22 Apr 2013
publication

Dichapetalins from Dichapetalum species and their cytotoxic properties

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11 Jan 2013
publication

Identification of novel inhibitors of DNA methylation by screening of a chemical library

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08 Jan 2013
publication

DNA methylation associated with polycomb repression in retinoic acid receptor β silencing

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03 Oct 2012
publication

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

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11 Sep 2012
publication

Epigenetics

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11 Aug 2012
publication

DNA methylation inhibitors in cancer: recent and future approaches

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23 Dec 2011
publication

Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors

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14 Dec 2011
publication

Rapid synthesis of new DNMT inhibitors derivatives of procainamide

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08 Dec 2011
publication

Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors

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23 Jun 2011
publication

Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters

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15 Jun 2011
publication

Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells

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01 Jun 2011
publication

C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development

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13 May 2011
publication

Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme–drug–DNA complex

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15 Apr 2011
publication

Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts

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01 Jan 2011
publication

DNA methyltransferase assays

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01 Dec 2010
publication

Introduction “DNA and chromosomes: Physical and biological approaches”

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24 Aug 2010
publication

Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine

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01 Jun 2010
publication

Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer

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23 Feb 2010
publication

Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins

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01 Apr 2009
publication

Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan

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25 Nov 2008
publication

Triplex formation on DNA targets: how to choose the oligonucleotide

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01 Aug 2008
publication

The triple helix: 50 years later, the outcome

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25 Feb 2008
publication

Targeting MDR1 gene: synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines

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21 Feb 2008
publication

Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence

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20 Dec 2007
publication

HU binds and folds single-stranded DNA

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01 Mar 2007
publication

“DNA, more than just a ladder”. A tribute to Michel Duguet (1943-2005)

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24 Feb 2007
publication

Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism

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22 Jun 2006
publication

Topoisomerase action on short DNA duplexes reveals requirements for gate and transfer DNA segments

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05 Apr 2006
publication

Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides

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25 Jan 2006
publication

Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds

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01 Jan 2006
publication

Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates

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01 Jul 2005
publication

Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties

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22 Mar 2005
publication

Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides

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18 Feb 2005
publication

Novel carbamate derivatives of 4-beta-amino-4′-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation

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27 Jan 2005
publication

Synthesis and biological study of a new series of 4′-demethylepipodophyllotoxin derivatives

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04 Oct 2004
publication

Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures

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22 Apr 2004
publication

Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin

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12 Feb 2004
publication

Relative DNA binding affinity of helix 3 homeodomain analogues, major groove binders, can be rapidly screened by displacement of prebound ethidium bromide. A comparative study

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15 Jul 2003
publication

Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin-oligonucleotide conjugates

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01 Jan 2003
publication

Synthesis and binding properties of oligo-2′-deoxyribonucleotides conjugated with triple-helix-specific intercalators: benzo[e] and benzo[g] pyridoindoles

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01 Jan 2003
publication

Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole

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15 Dec 2002
publication

A directional nucleation-zipping mechanism for triple helix formation

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01 Nov 2002
publication

Hemi-synthesis and biological activity of new analogues of podophyllotoxin

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01 Sep 2002
publication

Unusual DNA conformations: implications for telomeres

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08 Jan 2002
publication

Chemical modification of the third strand: differential effects on purine and pyrimidine triple helix formation

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27 Nov 2001
publication

Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I

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01 Nov 2001
publication

Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences

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25 Oct 2001
publication

DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives

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01 Jul 2001
publication

Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site

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13 Mar 2001
publication

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

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01 Mar 2001
publication

Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

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15 Feb 2001
publication

Detection of competing DNA structures by thermal gradient gel electrophoresis: from self-association to triple helix formation by (G,A)-containing oligonucleotides

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01 Jan 2001
publication

Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands

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15 Dec 2000
publication

Interaction of human DNA topoisomerase I with G-quartet structures

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01 Dec 2000
publication

Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity

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17 Nov 2000
publication

The chromosomal protein HMG-D binds to the TAR and RBE RNA of HIV-1

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01 Aug 2000
publication

Linkage of a triple helix-forming oligonucleotide to amsacrine-4-carboxamide derivatives modulates the sequence-selectivity of topoisomerase II-mediated DNA cleavage

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13 Apr 2000
publication

Pyrimidine morpholino oligonucleotides form a stable triple helix in the absence of magnesium ions

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01 Apr 2000
publication

Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides

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03 Sep 1999
publication

Energetics of strand-displacement reactions in triple helices: a spectroscopic study

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01 Sep 1999
publication

Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin

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24 Nov 1998
publication

Triple helix formation by (G,A)-containing oligonucleotides: asymmetric sequence effect

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19 Oct 1998
publication

Synthesis and Crystal Structure of a Self-Assembled, Octanuclear Oxo-Tantalum(V) Derivative Containing the First Example of a Transition Metal M(8)(&mgr;-O)(12) Cage

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