Link to Pubmed [PMID] – 15750651
Org. Biomol. Chem. 2005 Mar;3(6):1074-80
A novel series of carbamate derivatives of 4-beta-amino-4′-O-demethyl-4-desoxypodophyllotoxin were synthesized. Their effect on human DNA topoisomerase II and antiproliferative activity was evaluated. Compounds 4a-c, 4g, 4j and 4k are topoisomerase II poisons that induce double-stranded breaks in DNA and exhibit increased cytotoxicity compared to etoposide.