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© Research
Publication : Chemical record (New York, N.Y.)

Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chemical record (New York, N.Y.) - 10 Dec 2018

Lascano S, Lopez M, Arimondo PB

Link to Pubmed [PMID] – 30537358

Chem Rec 2018 Dec;18(12):1854-1876

DNA methylation and histone acetylation are widely studied epigenetic modifications. They are involved in numerous pathologies such as cancer, neurological disease, inflammation, obesity, etc. Since the discovery of the epigenome, numerous compounds have been developed to reverse DNA methylation and histone acetylation aberrant profile in diseases. Among them several were inspired by Nature and have a great interest as therapeutic molecules. In the quest of finding new ways to target epigenetic mechanisms, the use of chemical tools is a powerful strategy to better understand epigenetic mechanisms in biological systems. In this review we will present natural products reported as DNMT or HDAC inhibitors for anticancer treatments. We will then discuss the use of chemical tools that have been used in order to explore the epigenome.

https://www.ncbi.nlm.nih.gov/pubmed/30537358