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© Research
Event

Department of Structural Biology seminar: Dr Sébastien Ulrich, Applying concepts of supramolecular chemistry in delivery applications

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
27
Jan 2020
Time
14:30:00
25 Rue du Dr Roux, 75015 Paris, France
Address
Building: Monod Room: Amphithéâtre Mondo
Location
2020-01-27 14:30:00 2020-01-27 16:00:00 Europe/Paris Department of Structural Biology seminar: Dr Sébastien Ulrich, Applying concepts of supramolecular chemistry in delivery applications Lundi 27 janvier 2020 à 14h30 Amphithéâtre Monod – bâtiment Monod RdC   Dr. Sébastien Ulrich Institut des Biomolécules Max Mousseron (IBMM), CNRS, Université de Montpellier, ENSCM, Montpellier, France sebastien.ulrich@enscm.fr   Applying concepts of […] 25 Rue du Dr Roux, 75015 Paris, France Paola Arimondo paola.arimondo@pasteur.fr

About

Lundi 27 janvier 2020 à 14h30
Amphithéâtre Monod – bâtiment Monod RdC

 

Dr. Sébastien Ulrich
Institut des Biomolécules Max Mousseron (IBMM),
CNRS, Université de Montpellier, ENSCM, Montpellier, France
sebastien.ulrich@enscm.fr

 

Applying concepts of supramolecular chemistry in delivery applications

 

Abstract.
Supramolecular chemistry has put forward the concept of self-assembly as a spontaneous selfcorrecting synthetic approach for generating new entities that may be adaptive and responsive. We believe that such an approach can be particularly powerful in delivery applications in general, and nucleic acids delivery in particular, where the control of association and dissociation processes is of utmost importance. In this presentation, I will present our successes in the implementation of supramolecular and dynamic covalent chemistry for the smart delivery of nucleic acids, highlighting our recent results on supramolecular self-assemblies as well as dynamic covalent polymers.[1-8]

 

Related references:

[1] Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications, S. Ulrich, Acc. Chem. Res.,2019, 52, 510.

[2] Biomolecular dynamic covalent polymers for DNA complexation and siRNA delivery, C. Bouillon, Y. Bessin, F. Poncet, M. Gary-Bobo, P. Dumy, M. Barboiu, N. Bettache, S. Ulrich, J. Mater. Chem. B,2018, 6, 7239.

[3] Switching multivalent DNA complexation using metallo-controlled cationic supramolecular self-assemblies, W.

Drożdż, Y. Bessin, V. Gervais, X.-Y. Cao, J.-M. Lehn, A. R. Stefankiewicz, S. Ulrich, Chem. Eur. J.,2018, 24, 1518.

[4] Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems, E. Bartolami, C. Bouillon, P. Dumy, S. Ulrich, Chem. Commun.,2016, 52, 4257.

[5] Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening

and evaluation as siRNA vectors, E. Bartolami, Y. Bessin, N. Bettache, M. Gary-Bobo, M. Garcia, P. Dumy, S. Ulrich, Org. Biomol. Chem.,2015, 13, 9427.

[6] Dynamic expression of DNA complexation with self-assembled biomolecular clusters, E. Bartolami, Y. Bessin, V. Gervais, P. Dumy, S. Ulrich, Angew. Chem. Int. Ed.,2015, 54, 10183.

[7] Probing secondary interactions in biomolecular recognition by dynamic combinatorial chemistry S. Ulrich, P. Dumy, Chem. Commun.,2014, 50, 5810.

[8] Degradable hybrid materials based on cationic acylhydrazone dynamic covalent polymers promote DNA

complexation through multivalent interactions, C. Bouillon, D. Paolantoni, J. C. Rote, Y. Bessin, L. W. Peterson, P. Dumy, S. Ulrich, Chem. Eur. J.,2014, 20, 14705.

Contact : Paola Arimondo
Chimie biologique Epigénétique
Paola.arimondo@pasteur.fr

Location

Building: Monod
Room: Amphithéâtre Mondo
Address: 25 Rue du Dr Roux, 75015 Paris, France