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© Yang SI, Institut Pasteur
Publication : Nucleic acids research

The triple helix: 50 years later, the outcome

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleic acids research - 01 Aug 2008

Duca M, Vekhoff P, Oussedik K, Halby L, Arimondo PB

Link to Pubmed [PMID] – 18676453

Nucleic Acids Res. 2008 Sep;36(16):5123-38

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us.

https://www.ncbi.nlm.nih.gov/pubmed/18676453