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© Yang SI, Institut Pasteur
Publication : Nucleic acids research

Interaction of human DNA topoisomerase I with G-quartet structures

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleic acids research - 15 Dec 2000

Arimondo PB, Riou JF, Mergny JL, Tazi J, Sun JS, Garestier T, Hélène C

Link to Pubmed [PMID] – 11121473

Nucleic Acids Res. 2000 Dec;28(24):4832-8

Because of their role in the control of the topological state of DNA, topoisomerases are ubiquitous and vital enzymes, which participate in nearly all events related to DNA metabolism including replication and transcription. We show here that human topoisomerase I (Topo I) plays an unexpected role of ‘molecular matchmaker’ for G-quartet formation. G-quadruplexes are multi-stranded structures held together by square planes of four guanines (‘G-quartets’) interacting by forming Hoogsteen hydrogen bonds. Topo I is able to promote the formation of four-stranded intermolecular DNA structures when added to single-stranded DNA containing a stretch of at least five guanines. We provide evidence that these complexes are parallel G-quartet structures, mediated by tetrads of hydrogen-bonded guanine. In addition, Topo I binds specifically to pre-formed parallel and anti-parallel G4-DNA.

https://www.ncbi.nlm.nih.gov/pubmed/11121473