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© Research
Event

Department of Structural Biology and Chemistry: Michaela Frye, RNA methylation in stem cells and cancer

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
30
Apr 2019
Time
14:00:00
28 Rue du Dr Roux, Paris, France
Address
Building: François Jacob Room: Auditorium François Jacob
Location
2019-04-30 14:00:00 2019-04-30 16:00:00 Europe/Paris Department of Structural Biology and Chemistry: Michaela Frye, RNA methylation in stem cells and cancer Department of Structural Biology and Chemistry SEMINAR Mardi 30 avril 2019 à 14h00 Salle AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c Dr. Michaela Frye German Cancer Research Center – DKFZ, Im Neuenheimer Feld […] 28 Rue du Dr Roux, Paris, France Paola Arimondo paola.arimondo@pasteur.fr

About

Department of Structural Biology and Chemistry

SEMINAR

Mardi 30 avril 2019 à 14h00

Salle AUDITORIUM CENTRE F. JACOB – CFJ RdC 17c

Dr. Michaela Frye

German Cancer Research Center – DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

RNA methylation in stem cells and cancer

Many of the hundreds of known chemical modifications in RNA were discovered over forty years ago but then forgotten because suitable, sensitive tools to detect the modifications at high resolution were lacking. Through the development of novel biochemical, functional and genomics tools we are only now beginning to understand the whole breadth and extensive functional roles of RNA modifications in higher organisms. I will present some mechanistic examples how RNA modifications help to shape normal tissue homeostasis, and how aberrant formation of RNA modifications contributes to disease. By focusing on the roles of transfer RNA (tRNA) modification in regulating gene expression, I will discuss novel and emerging molecular functions of RNA modifications in abundant non-coding RNAs. Together, our work demonstrates that by understanding the role of RNA modifications in physiology and pathology, novel and powerful therapeutic drug targets for human diseases and can potentially be identified and further optimized for clinical studies.

 

Contact : Paola Arimondo

Unité Chimie Biologique Epigénétique

paola.arimondo@pasteur.fr

Location

Building: François Jacob
Room: Auditorium François Jacob
Address: 28 Rue du Dr Roux, Paris, France