Ligne de temps
Paola Arimondo
Responsable de Structure
02 déc. 2024
publication
High Content Screening Assay of Inhibitors of the Legionella Pneumophila Histone Methyltransferase RomA in Infected Cells.
Lire plus05 nov. 2024
publication
Supercomputer-based virtual screening for DNMT1 inhibitors as novel anticancer agents
Lire plus01 oct. 2024
event
3rd PPU Oxford bilateral summit “Chimie Biologique” – “Tackling AntiMicrobial Resistance, together”
Lire plus27 sept. 2024
event
Thesis defense – Synthesis and identification of chemical compounds targeting DNA Methylation reader proteins (By Jean Contreras)
Lire plus18 avr. 2024
12 avr. 2024
event
“Tackling antibacterial and antifungal resistant infections from disease to innovative therapies” – an international AMR symposium
Lire plus05 avr. 2024
publication
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
Lire plus05 avr. 2024
publication
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
Lire plus01 avr. 2024
publication
Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization.
Lire plus20 févr. 2024
publication
Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
Lire plus11 oct. 2023
18 sept. 2023
event
Joint Microbiology, BCI, and Structural Biology and Chemistry Departments seminar: Melanie OTT (UCSF, USA) ; “Understanding SARS-CoV-2 Variants through Reverse Genetics” ; Wenesday 27 September @2.00pm; Jules Bordet room
Lire plus01 sept. 2023
31 août 2023
publication
A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation
Lire plus31 août 2023
publication
A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation
Lire plus27 juil. 2023
29 juin 2023
event
“Enjeux politiques de l’antibiorésistance” – Un symposium conjoint Institut Pasteur – Sciences Po
Lire plus22 mai 2023
publication
Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.
Lire plus22 mars 2023
17 févr. 2023
publication
Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum.
Lire plus27 janv. 2023
12 janv. 2023
event
New antiviral strategies: from bench to bedside – A joint Société de Chimie Thérapeutique, Société Française de Virologie & Institut Pasteur Symposium
Lire plus11 janv. 2023
news
New publication: Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum
Lire plus20 sept. 2022
publication
DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness.
Lire plus01 juin 2022
12 mai 2022
event
2nd PPU-Oxford Bilateral Summit ” Chimie Biologique” – Linking Chemistry and Microbiology to fight human Infectious Diseases
Lire plus10 mai 2022
event
2nd joint Université Paris Cité – Institut Pasteur Antimicrobial Resistance Symposium & Microb’UP Anniversary meeting
Lire plus10 mai 2022
event
Research and innovation to reduce the burden of antibiotic resistance: strengthening the European action
Lire plus04 avr. 2022
01 avr. 2022
publication
Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies.
Lire plus16 mars 2022
07 janv. 2022
01 déc. 2021
publication
Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction.
Lire plus02 nov. 2021
publication
Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation
Lire plus26 oct. 2021
publication
The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor.
Lire plus09 sept. 2021
31 août 2021
publication
Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein
Lire plus30 août 2021
15 août 2021
publication
Direct Synthesis of Allyl Amines with 2‐Nitrosulfonamide Derivatives via the Tsuji‐Trost Reaction
Lire plus22 juil. 2021
publication
Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.
Lire plus04 mars 2021
25 févr. 2021
project
DIM 1 HEALTH 2019 project : EpiK- The Cytosine code as potent target to kill pathogens and fight human diseases
Lire plus18 févr. 2021
project
Epi-Med: synthesis and biological evaluation of new active molecules against MLL-rearranged leukaemia.
Lire plus18 févr. 2021
project
EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –
Lire plus07 janv. 2021
publication
Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest.
Lire plus17 sept. 2020
publication
Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’
Lire plus28 août 2020
02 juil. 2020
15 mai 2020
publication
Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines.
Lire plus19 mars 2020
publication
Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs.
Lire plus14 févr. 2020
publication
Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation
Lire plus22 janv. 2020
publication
DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites.
Lire plus15 janv. 2020
event
Department of Structural Biology seminar: Dr Sébastien Ulrich, Applying concepts of supramolecular chemistry in delivery applications
Lire plus02 déc. 2019
01 nov. 2019
publication
Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells.
Lire plus01 oct. 2019
publication
[Chemical targeting of DNA and histone methylation in cancer: Novelties, hopes and promises].
Lire plus24 sept. 2019
17 sept. 2019
event
Department of Structural Biology and Chemistry: Jurgen Brem, Enabling antibiotics to combat multidrug resistant bacteria
Lire plus03 août 2019
01 juin 2019
22 févr. 2019
event
Department of Structural Biology and Chemistry: Michaela Frye, RNA methylation in stem cells and cancer
Lire plus16 janv. 2019
publication
Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma
Lire plus02 janv. 2019
02 janv. 2019
publication
Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells
Lire plus02 janv. 2019
publication
Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide
Lire plus10 déc. 2018
publication
Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers
Lire plus07 déc. 2018
17 oct. 2018
publication
Identification of novel quinazoline derivatives as potent antiplasmodial agents
Lire plus29 juin 2018
publication
A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy
Lire plus05 juin 2018
publication
The past and presence of gene targeting: from chemicals and DNA via proteins to RNA
Lire plus05 juin 2018
publication
Lire plus
09 avr. 2018
06 avr. 2018
03 avr. 2018
event
Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies – Nathaniel I. Martin Phd
Lire plus29 mars 2018
event
Bisubstrate analogues as N-methyltransferase inhibitors and tool compounds for structural studies
Lire plus16 janv. 2018
16 janv. 2018
15 janv. 2018
publication
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches
Lire plus09 janv. 2018
10 août 2017
publication
Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors
Lire plus23 mai 2017
publication
Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells
Lire plus17 févr. 2017
05 janv. 2017
09 déc. 2016
publication
DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies
Lire plus31 août 2016
publication
Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells
Lire plus15 mars 2016
publication
Identification and optimization of hydrazone-gallate derivatives as specific inhibitors of DNA methyltransferase 3A
Lire plus01 janv. 2016
10 juil. 2015
20 juin 2015
publication
Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2′-deoxycytidine in human leukemic KG1 cells
Lire plus23 janv. 2015
01 janv. 2015
publication
DNA Methylation Analysis of ChIP Products at Single Nucleotide Resolution by Pyrosequencing®
Lire plus18 déc. 2014
publication
New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors
Lire plus04 déc. 2014
15 sept. 2014
26 août 2014
01 juil. 2014
publication
Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy
Lire plus08 mai 2014
publication
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity
Lire plus01 mars 2014
publication
Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation
Lire plus03 févr. 2014
publication
Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers
Lire plus15 janv. 2014
publication
Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells
Lire plus09 janv. 2014
publication
Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1
Lire plus25 août 2013
publication
Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies
Lire plus22 avr. 2013
11 janv. 2013
publication
Identification of novel inhibitors of DNA methylation by screening of a chemical library
Lire plus08 janv. 2013
publication
DNA methylation associated with polycomb repression in retinoic acid receptor β silencing
Lire plus03 oct. 2012
publication
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies
Lire plus11 sept. 2012
11 août 2012
23 déc. 2011
14 déc. 2011
08 déc. 2011
publication
Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors
Lire plus23 juin 2011
publication
Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters
Lire plus15 juin 2011
publication
Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells
Lire plus01 juin 2011
publication
C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development
Lire plus13 mai 2011
publication
Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme–drug–DNA complex
Lire plus15 avr. 2011
publication
Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts
Lire plus01 janv. 2011
01 déc. 2010
24 août 2010
publication
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine
Lire plus01 juin 2010
publication
Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer
Lire plus23 févr. 2010
01 avr. 2009
publication
Optimized synthesis and enhanced efficacy of novel triplex-forming camptothecin derivatives based on gimatecan
Lire plus25 nov. 2008
01 août 2008
25 févr. 2008
publication
Targeting MDR1 gene: synthesis and cellular study of modified daunomycin-triplex-forming oligonucleotide conjugates able to inhibit gene expression in resistant cell lines
Lire plus21 févr. 2008
publication
Single-molecule observations of topotecan-mediated TopIB activity at a unique DNA sequence
Lire plus20 déc. 2007
01 mars 2007
24 févr. 2007
publication
Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism
Lire plus22 juin 2006
publication
Topoisomerase action on short DNA duplexes reveals requirements for gate and transfer DNA segments
Lire plus05 avr. 2006
publication
Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides
Lire plus25 janv. 2006
publication
Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds
Lire plus01 janv. 2006
publication
Exploring the cellular activity of camptothecin-triple-helix-forming oligonucleotide conjugates
Lire plus01 juil. 2005
publication
Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties
Lire plus22 mars 2005
publication
Activation of camptothecin derivatives by conjugation to triple helix-forming oligonucleotides
Lire plus18 févr. 2005
publication
Novel carbamate derivatives of 4-beta-amino-4′-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation
Lire plus27 janv. 2005
publication
Synthesis and biological study of a new series of 4′-demethylepipodophyllotoxin derivatives
Lire plus04 oct. 2004
publication
Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures
Lire plus22 avr. 2004
publication
Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin
Lire plus12 févr. 2004
publication
Relative DNA binding affinity of helix 3 homeodomain analogues, major groove binders, can be rapidly screened by displacement of prebound ethidium bromide. A comparative study
Lire plus15 juil. 2003
publication
Spatial organization of topoisomerase I-mediated DNA cleavage induced by camptothecin-oligonucleotide conjugates
Lire plus01 janv. 2003
publication
Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole
Lire plus01 janv. 2003
publication
Synthesis and binding properties of oligo-2′-deoxyribonucleotides conjugated with triple-helix-specific intercalators: benzo[e] and benzo[g] pyridoindoles
Lire plus15 déc. 2002
01 nov. 2002
01 sept. 2002
08 janv. 2002
publication
Chemical modification of the third strand: differential effects on purine and pyrimidine triple helix formation
Lire plus27 nov. 2001
publication
Design and optimization of camptothecin conjugates of triple helix-forming oligonucleotides for sequence-specific DNA cleavage by topoisomerase I
Lire plus01 nov. 2001
publication
Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences
Lire plus25 oct. 2001
publication
DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives
Lire plus01 juil. 2001
publication
Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site
Lire plus13 mars 2001
publication
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
Lire plus01 mars 2001
publication
Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes
Lire plus15 févr. 2001
publication
Detection of competing DNA structures by thermal gradient gel electrophoresis: from self-association to triple helix formation by (G,A)-containing oligonucleotides
Lire plus01 janv. 2001
publication
Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands
Lire plus15 déc. 2000
01 déc. 2000
publication
Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity
Lire plus17 nov. 2000
01 août 2000
publication
Linkage of a triple helix-forming oligonucleotide to amsacrine-4-carboxamide derivatives modulates the sequence-selectivity of topoisomerase II-mediated DNA cleavage
Lire plus13 avr. 2000
publication
Pyrimidine morpholino oligonucleotides form a stable triple helix in the absence of magnesium ions
Lire plus01 avr. 2000
publication
Recognition and cleavage of DNA by rebeccamycin- or benzopyridoquinoxaline conjugated of triple helix-forming oligonucleotides
Lire plus03 sept. 1999
publication
Energetics of strand-displacement reactions in triple helices: a spectroscopic study
Lire plus01 sept. 1999
publication
Targeting topoisomerase I cleavage to specific sequences of DNA by triple helix-forming oligonucleotide conjugates. A comparison between a rebeccamycin derivative and camptothecin
Lire plus24 nov. 1998
publication
Triple helix formation by (G,A)-containing oligonucleotides: asymmetric sequence effect
Lire plus19 oct. 1998
publication