Timeline
Didier Mazel
Head of Structure
12 Jan 2024
publication
Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems
Read more03 Jan 2024
publication
Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites
Read more02 Mar 2023
publication
Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae.
Read more09 Feb 2023
news
Register for the free MOOC Webinar Resistance to Antibacterial Agents ! Feb. 17th – 2pm
Read more27 Jan 2023
10 Nov 2022
05 Nov 2022
publication
Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae.
Read more01 Feb 2022
18 Nov 2021
publication
Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae.
Read more08 Nov 2021
publication
The coordinated replication of Vibrio cholerae’s two chromosomes required the acquisition of a unique domain by the RctB initiator.
Read more22 Oct 2021
publication
Sleeping ribosomes: Bacterial signaling triggers RaiA mediated persistence to aminoglycosides.
Read more01 Oct 2021
publication
Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae.
Read more09 Jun 2021
news
Highlighted publication : “Cassette recruitment in the chromosomal Integron of Vibrio cholerae”, Vit et al., NAR, Bacterial Genome Plasticity team.
Read more28 May 2021
06 Jan 2021
event
G&G PhD Thesis – “VchM – a DNA cytosine methyltransferase modulates the response of Vibrio cholerae to proteotoxic stress”
Read more01 Jan 2021
publication
Real-time tracking of bacterial membrane vesicles reveals enhanced membrane traffic upon antibiotic exposure.
Read more15 Dec 2020
publication
Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions.
Read more01 Jul 2020
publication
Structure-specific DNA recombination sites: Design, validation, and machine learning-based refinement.
Read more29 Apr 2020
publication
Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae.
Read more05 Oct 2019
project
RepliChroms : Replication Control in Bacteria w/ Multiple Chromosomes (ANR-19-CE12-0001)
Read more02 Jul 2019
14 May 2019
news
Remerciements à Didier Mazel qui a dirigé le Département Génomes et Génétique de 2009 à 2019
Read more14 May 2019
22 Feb 2019
event
“The Gene Machine: The race for the structure of the ribosome” by Sir Venki RAMAKRISHNAN – Genomes and Genetics and Structural Biology and Chemistry DPT seminar
Read more20 Jan 2019
publication
Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations
Read more02 Nov 2018
publication
Vibrio cholerae chromosome 2 copy number is controlled by the methylation-independent binding of its monomeric initiator to the chromosome 1 crtS site.
Read more21 May 2018
publication
Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation
Read more14 Mar 2018
event
“Caractérisation de la protéine RadD et identification des gènes essentiels en présence de faibles doses de tobramycine”
Read more01 Jan 2018
17 Oct 2017
publication
Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation.
Read more29 Jul 2017
publication
Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality
Read more14 Jul 2017
publication
An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.
Read more28 Mar 2017
publication
Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance.
Read more28 Feb 2017
publication
The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication
Read more09 Dec 2016
project
2017 Genomes Genetics Seminars Schedule (Thursdays, From January 5th to December 21st)
Read more05 Aug 2016
publication
Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites.
Read more13 Apr 2016
01 Apr 2016
publication
A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae.
Read more10 Mar 2016
publication
Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation.
Read more17 Nov 2015
publication
A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters
Read more10 Sep 2015
09 Jun 2015
09 Jun 2015
09 Jun 2015
11 May 2015
20 Apr 2015
publication
Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron
Read more01 Dec 2014
01 Nov 2014
22 Oct 2014
15 Sep 2014
16 Jun 2014
publication
Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli
Read more10 Mar 2014
publication
The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae
Read more01 Feb 2014
01 Feb 2014
publication
Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.
Read more02 Dec 2013
publication
The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites.
Read more06 Jun 2013
publication
Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits
Read more08 Mar 2013
publication
Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons
Read more01 Jan 2013
01 Jan 2013
publication
RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae.
Read more09 Oct 2012
publication
Antibiotics as physiological stress inducers and bacterial response to the challenge
Read more14 Jun 2012
publication
Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting
Read more01 Apr 2012
publication
Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase.
Read more01 Jan 2012
19 Aug 2011
publication
High-level gene cassette transcription prevents integrase expression in class 1 integrons
Read more01 May 2011
publication
Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.
Read more30 Apr 2011
publication
Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons
Read more08 Oct 2010
publication
Silent mischief: bacteriophage Mu insertions contaminate products of Escherichia coli random mutagenesis performed using suicidal transposon delivery plasmids mobilized by broad-host-range RP4 conjugative machinery
Read more06 Sep 2010
publication
Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids
Read more01 Sep 2010
17 Jul 2010
publication
Vibrio aestuarianus zinc metalloprotease causes lethality in the Pacific oyster Crassostrea gigas and impairs the host cellular immune defenses
Read more09 Jun 2010
13 Jan 2010
publication
The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas
Read more08 Jan 2010
publication
Inverse correlation between promoter strength and excision activity in class 1 integrons
Read more01 Jan 2010
01 Jan 2010
publication
[The SOS response controls antibiotic resistance by regulating the integrase of integrons]
Read more13 Nov 2009
publication
The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity
Read more26 May 2009
publication
Translation regulation of integrons gene cassette expression by the attC sites
Read more22 May 2009
01 Apr 2009
publication
Genome sequence of Vibrio splendidus: an abundant planctonic marine species with a large genotypic diversity
Read more14 Nov 2008
03 Oct 2008
publication
Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus
Read more27 Jun 2008
21 Mar 2008
publication
Correlation between detection of a plasmid and high-level virulence of Vibrio nigripulchritudo, a pathogen of the shrimp Litopenaeus stylirostris
Read more26 Feb 2008
publication
Delineation of the recombination sites necessary for integration of pathogenicity islands II and III into the Escherichia coli 536 chromosome
Read more20 Sep 2007
publication
Identification of key structural determinants of the IntI1 integron integrase that influence attC x attI1 recombination efficiency
Read more23 Apr 2007
publication
Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants
Read more01 Mar 2007
publication
Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection
Read more26 Jan 2007
publication
Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7
Read more22 Nov 2006
publication
Construction of a Vibrio splendidus mutant lacking the metalloprotease gene vsm by use of a novel counterselectable suicide vector
Read more01 Aug 2006
27 Apr 2006
08 Dec 2005
publication
Integron cassette insertion: a recombination process involving a folded single strand substrate
Read more19 Aug 2005
publication
The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.
Read more01 Jul 2005
publication
Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli isolates from healthy subjects free of recent antibiotic exposure
Read more01 Mar 2005
publication
Comparative study of class 1 integron and Vibrio cholerae superintegron integrase activities
Read more01 Mar 2005
publication
A new family of mobilizable suicide plasmids based on broad host range R388 plasmid (IncW) and RP4 plasmid (IncPalpha) conjugative machineries and their cognate Escherichia coli host strains
Read more01 Jul 2004
publication
A new family of conditional replicating plasmids and their cognate Escherichia coli host strains
Read more01 Oct 2003
publication
Erythromycin esterase gene ere(A) is located in a functional gene cassette in an unusual class 2 integron
Read more01 Mar 2003
publication
Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae
Read more01 Jul 2002
01 Mar 2002
publication