Ligne de temps
Didier Mazel
Responsable de Structure
08 nov. 2024
event
Genomes and Genetique department seminar : Mireille BETERMIER (Institute for Integrative Biology of the Cell Université Paris-Saclay) Auditorium François Jacob
Lire plus04 oct. 2024
event
Genomes and Genetique department seminar : Meriem EL KAROUI (ENS PARIS SACLAY FRANCE) Auditorium François Jacob
Lire plus01 août 2024
publication
Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations
Lire plus10 juil. 2024
05 juin 2024
publication
Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated to queuosine tRNA modification
Lire plus12 janv. 2024
publication
Cassette recombination dynamics within chromosomal integrons are regulated by toxin-antitoxin systems.
Lire plus03 janv. 2024
publication
Integron cassettes integrate into bacterial genomes via widespread non-classical attG sites.
Lire plus02 mars 2023
publication
Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae.
Lire plus09 févr. 2023
news
Register for the free MOOC Webinar Resistance to Antibacterial Agents ! Feb. 17th – 2pm
Lire plus27 janv. 2023
10 nov. 2022
05 nov. 2022
publication
Systematic transcriptome analysis allows the identification of new type I and type II Toxin/Antitoxin systems located in the superintegron of Vibrio cholerae.
Lire plus01 févr. 2022
18 nov. 2021
publication
Interplay between Sublethal Aminoglycosides and Quorum Sensing: Consequences on Survival in V. cholerae.
Lire plus08 nov. 2021
publication
The coordinated replication of Vibrio cholerae’s two chromosomes required the acquisition of a unique domain by the RctB initiator.
Lire plus22 oct. 2021
publication
Sleeping ribosomes: Bacterial signaling triggers RaiA mediated persistence to aminoglycosides.
Lire plus01 oct. 2021
publication
Deficiency in cytosine DNA methylation leads to high chaperonin expression and tolerance to aminoglycosides in Vibrio cholerae.
Lire plus09 juin 2021
news
Highlighted publication : “Cassette recruitment in the chromosomal Integron of Vibrio cholerae”, Vit et al., NAR, Bacterial Genome Plasticity team.
Lire plus04 juin 2021
06 janv. 2021
event
G&G PhD Thesis – “VchM – a DNA cytosine methyltransferase modulates the response of Vibrio cholerae to proteotoxic stress”
Lire plus01 janv. 2021
publication
Real-time tracking of bacterial membrane vesicles reveals enhanced membrane traffic upon antibiotic exposure.
Lire plus15 déc. 2020
publication
Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions.
Lire plus01 juil. 2020
publication
Structure-specific DNA recombination sites: Design, validation, and machine learning–based refinement
Lire plus29 avr. 2020
publication
Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae.
Lire plus05 oct. 2019
02 juil. 2019
14 mai 2019
news
Remerciements à Didier Mazel qui a dirigé le Département Génomes et Génétique de 2009 à 2019
Lire plus14 mai 2019
22 févr. 2019
event
“The Gene Machine: The race for the structure of the ribosome” by Sir Venki RAMAKRISHNAN – Genomes and Genetics and Structural Biology and Chemistry DPT seminar
Lire plus20 janv. 2019
publication
Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations
Lire plus02 nov. 2018
publication
Vibrio cholerae chromosome 2 copy number is controlled by the methylation-independent binding of its monomeric initiator to the chromosome 1 crtS site.
Lire plus21 mai 2018
publication
Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation
Lire plus14 mars 2018
event
“Caractérisation de la protéine RadD et identification des gènes essentiels en présence de faibles doses de tobramycine”
Lire plus01 janv. 2018
01 janv. 2018
publication
Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation.
Lire plus29 juil. 2017
publication
Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality
Lire plus14 juil. 2017
publication
An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.
Lire plus28 mars 2017
publication
Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance.
Lire plus28 févr. 2017
publication
The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication
Lire plus09 déc. 2016
project
2017 Genomes Genetics Seminars Schedule (Thursdays, From January 5th to December 21st)
Lire plus19 sept. 2016
publication
Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites.
Lire plus13 avr. 2016
01 avr. 2016
publication
A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae.
Lire plus10 mars 2016
publication
Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation.
Lire plus17 nov. 2015
publication
A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters
Lire plus10 sept. 2015
09 juin 2015
09 juin 2015
09 juin 2015
11 mai 2015
20 avr. 2015
publication
Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron
Lire plus01 déc. 2014
01 nov. 2014
22 oct. 2014
15 sept. 2014
16 juin 2014
publication
Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli
Lire plus10 mars 2014
publication
The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae
Lire plus01 févr. 2014
publication
Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase.
Lire plus01 févr. 2014
publication
The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites.
Lire plus01 févr. 2014
06 juin 2013
publication
Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits
Lire plus08 mars 2013
publication
Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons
Lire plus01 janv. 2013
01 janv. 2013
publication
RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae.
Lire plus09 oct. 2012
publication
Antibiotics as physiological stress inducers and bacterial response to the challenge
Lire plus14 juin 2012
publication
Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting
Lire plus01 avr. 2012
publication
Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase.
Lire plus01 janv. 2012
19 août 2011
publication
High-level gene cassette transcription prevents integrase expression in class 1 integrons
Lire plus01 mai 2011
publication
Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance.
Lire plus30 avr. 2011
publication
Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons
Lire plus08 oct. 2010
publication
Silent mischief: bacteriophage Mu insertions contaminate products of Escherichia coli random mutagenesis performed using suicidal transposon delivery plasmids mobilized by broad-host-range RP4 conjugative machinery
Lire plus06 sept. 2010
publication
Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids
Lire plus01 sept. 2010
17 juil. 2010
publication
Vibrio aestuarianus zinc metalloprotease causes lethality in the Pacific oyster Crassostrea gigas and impairs the host cellular immune defenses
Lire plus09 juin 2010
13 janv. 2010
publication
The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas
Lire plus08 janv. 2010
publication
Inverse correlation between promoter strength and excision activity in class 1 integrons
Lire plus01 janv. 2010
01 janv. 2010
publication
[The SOS response controls antibiotic resistance by regulating the integrase of integrons]
Lire plus13 nov. 2009
publication
The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity
Lire plus26 mai 2009
publication
Translation regulation of integrons gene cassette expression by the attC sites
Lire plus22 mai 2009
01 avr. 2009
publication
Genome sequence of Vibrio splendidus: an abundant planctonic marine species with a large genotypic diversity
Lire plus14 nov. 2008
03 oct. 2008
publication
Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus
Lire plus27 juin 2008
21 mars 2008
publication
Correlation between detection of a plasmid and high-level virulence of Vibrio nigripulchritudo, a pathogen of the shrimp Litopenaeus stylirostris
Lire plus26 févr. 2008
publication
Delineation of the recombination sites necessary for integration of pathogenicity islands II and III into the Escherichia coli 536 chromosome
Lire plus20 sept. 2007
publication
Identification of key structural determinants of the IntI1 integron integrase that influence attC x attI1 recombination efficiency
Lire plus23 avr. 2007
publication
Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants
Lire plus01 mars 2007
publication
Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection
Lire plus26 janv. 2007
publication
Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7
Lire plus22 nov. 2006
publication
Construction of a Vibrio splendidus mutant lacking the metalloprotease gene vsm by use of a novel counterselectable suicide vector
Lire plus01 août 2006
27 avr. 2006
08 déc. 2005
publication
Integron cassette insertion: a recombination process involving a folded single strand substrate
Lire plus19 août 2005
publication
The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae.
Lire plus01 juil. 2005
publication
Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli isolates from healthy subjects free of recent antibiotic exposure
Lire plus01 mars 2005
publication
A new family of mobilizable suicide plasmids based on broad host range R388 plasmid (IncW) and RP4 plasmid (IncPalpha) conjugative machineries and their cognate Escherichia coli host strains
Lire plus01 mars 2005
publication
Comparative study of class 1 integron and Vibrio cholerae superintegron integrase activities
Lire plus01 juil. 2004
publication
A new family of conditional replicating plasmids and their cognate Escherichia coli host strains
Lire plus01 oct. 2003
publication
Erythromycin esterase gene ere(A) is located in a functional gene cassette in an unusual class 2 integron
Lire plus01 mars 2003
publication
Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae
Lire plus01 juil. 2002
01 mars 2002
publication