Ligne de temps

Didier Mazel
Responsable de Structure
01 Jul 2020
publication

Structure-specific DNA recombination sites: Design, validation, and machine learning-based refinement.

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29 Apr 2020
publication

Macromolecular crowding links ribosomal protein gene dosage to growth rate in Vibrio cholerae

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05 Oct 2019
project

RepliChroms : Replication Control in Bacteria with Multiple Chromosomes

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02 Jul 2019
publication

RadD Contributes to R-Loop Avoidance in Sub-MIC Tobramycin.

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14 May 2019
news

Remerciements à Didier Mazel qui a dirigé le Département Génomes et Génétique de 2009 à 2019

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14 May 2019
news

A new bacteria-killing weapon in the fight against antibiotic resistance

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22 Feb 2019
event

“The Gene Machine: The race for the structure of the ribosome” by Sir Venki RAMAKRISHNAN – Genomes and Genetics and Structural Biology and Chemistry DPT seminar

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20 Jan 2019
publication

Engineered toxin-intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations

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02 Nov 2018
publication

Vibrio cholerae chromosome 2 copy number is controlled by the methylation-independent binding of its monomeric initiator to the chromosome 1 crtS site

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07 Aug 2018
publication

Replicate Once Per Cell Cycle: Replication Control of Secondary Chromosomes

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21 May 2018
publication

Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation

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14 Mar 2018
event

“Caractérisation de la protéine RadD et identification des gènes essentiels en présence de faibles doses de tobramycine”

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17 Oct 2017
publication

Recoding of synonymous genes to expand evolutionary landscapes requires control of secondary structure affecting translation

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29 Jul 2017
publication

Dynamic stepwise opening of integron attC DNA hairpins by SSB prevents toxicity and ensures functionality

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14 Jul 2017
publication

An att site-based recombination reporter system for genome engineering and synthetic DNA assembly.

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28 Mar 2017
publication

Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance

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28 Feb 2017
publication

The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication

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09 Dec 2016
project

2017 Genomes Genetics Seminars Schedule (Thursdays, From January 5th to December 21st)

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05 Aug 2016
publication

Efficiency of integron cassette insertion in correct orientation is ensured by the interplay of the three unpaired features of attC recombination sites.

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22 Apr 2016
publication

A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae.

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13 Apr 2016
project

Induction of stress responses and mutagenesis by low doses of antibiotics

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10 Mar 2016
publication

Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation.

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17 Nov 2015
team

Bioinformatique évolutive

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17 Nov 2015
publication

A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters

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10 Sep 2015
project

ANR Magisbac : Genesis and Maintenance of Bacterial Secondary Chromosomes

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09 Jun 2015
project

Plasticity of the Vibrio species genomes

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09 Jun 2015
project

Integrons

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09 Jun 2015
project

Extension of the evolutionary potential of any gene

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11 May 2015
team

Plasticité du Génome Bactérien

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20 Apr 2015
publication

Comprehensive Functional Analysis of the 18 Vibrio cholerae N16961 Toxin-Antitoxin Systems Substantiates Their Role in Stabilizing the Superintegron

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13 Apr 2015
publication

Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity

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01 Dec 2014
publication

Management of multipartite genomes: the Vibrio cholerae model

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22 Oct 2014
publication

VIBRIO 2014 meeting report

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15 Sep 2014
department

Génomes et Génétique

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30 Jun 2014
publication

SOS, the formidable strategy of bacteria against aggressions

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16 Jun 2014
publication

Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli

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10 Mar 2014
publication

The superintegron integrase and the cassette promoters are co-regulated in Vibrio cholerae

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07 Jan 2014
publication

Fuse or die: how to survive the loss of Dam in Vibrio cholerae

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06 Dec 2013
publication

Identification of genes involved in low aminoglycoside-induced SOS response in Vibrio cholerae: a role for transcription stalling and Mfd helicase

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02 Dec 2013
publication

The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites

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06 Jun 2013
publication

Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits

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11 Apr 2013
publication

RpoS plays a central role in the SOS induction by sub-lethal aminoglycoside concentrations in Vibrio cholerae

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08 Mar 2013
publication

Characterization of the phd-doc and ccd toxin-antitoxin cassettes from Vibrio superintegrons

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01 Jan 2013
publication

Shuffling of DNA cassettes in a synthetic integron

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09 Oct 2012
publication

Antibiotics as physiological stress inducers and bacterial response to the challenge

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26 Jun 2012
publication

Replicative resolution of integron cassette insertion

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14 Jun 2012
publication

Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting

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27 Jan 2012
publication

Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase

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12 Jan 2012
publication

Genome engineering in Vibrio cholerae: a feasible approach to address biological issues

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01 Jan 2012
publication

A natural system of chromosome transfer in Yersinia pseudotuberculosis.

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19 Aug 2011
publication

High-level gene cassette transcription prevents integrase expression in class 1 integrons

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30 Apr 2011
publication

Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons

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07 Feb 2011
publication

Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance

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01 Dec 2010
publication

Folded DNA in action: hairpin formation and biological functions in prokaryotes

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08 Oct 2010
publication

Silent mischief: bacteriophage Mu insertions contaminate products of Escherichia coli random mutagenesis performed using suicidal transposon delivery plasmids mobilized by broad-host-range RP4 conjugative machinery

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06 Sep 2010
publication

Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids

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01 Sep 2010
publication

Vibrio2009: the third international conference on the biology of Vibrios

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17 Jul 2010
publication

Vibrio aestuarianus zinc metalloprotease causes lethality in the Pacific oyster Crassostrea gigas and impairs the host cellular immune defenses

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13 Jul 2010
publication

Cellular pathways controlling integron cassette site folding

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09 Jun 2010
publication

The synthetic integron: an in vivo genetic shuffling device

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19 Jan 2010
publication

An end-joining repair mechanism in Escherichia coli

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13 Jan 2010
publication

The major outer membrane protein OmpU of Vibrio splendidus contributes to host antimicrobial peptide resistance and is required for virulence in the oyster Crassostrea gigas

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08 Jan 2010
publication

Inverse correlation between promoter strength and excision activity in class 1 integrons

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01 Jan 2010
publication

[The SOS response controls antibiotic resistance by regulating the integrase of integrons]

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01 Jan 2010
publication

Integrons

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13 Nov 2009
publication

The relaxed requirements of the integron cleavage site allow predictable changes in integron target specificity

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04 Sep 2009
publication

Structural features of single-stranded integron cassette attC sites and their role in strand selection

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26 May 2009
publication

Translation regulation of integrons gene cassette expression by the attC sites

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22 May 2009
publication

The SOS response controls integron recombination

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01 Apr 2009
publication

Genome sequence of Vibrio splendidus: an abundant planctonic marine species with a large genotypic diversity

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14 Nov 2008
publication

Synonymous genes explore different evolutionary landscapes

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03 Oct 2008
publication

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus

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27 Jun 2008
publication

Construction of an improved RP4 (RK2)-based conjugative system

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21 Mar 2008
publication

Correlation between detection of a plasmid and high-level virulence of Vibrio nigripulchritudo, a pathogen of the shrimp Litopenaeus stylirostris

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26 Feb 2008
publication

Delineation of the recombination sites necessary for integration of pathogenicity islands II and III into the Escherichia coli 536 chromosome

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20 Sep 2007
publication

Identification of key structural determinants of the IntI1 integron integrase that influence attC x attI1 recombination efficiency

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23 Apr 2007
publication

Vibrio splendidus as the source of plasmid-mediated QnrS-like quinolone resistance determinants

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01 Mar 2007
publication

Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection

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26 Jan 2007
publication

Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7

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22 Nov 2006
publication

Construction of a Vibrio splendidus mutant lacking the metalloprotease gene vsm by use of a novel counterselectable suicide vector

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01 Aug 2006
publication

Integrons: agents of bacterial evolution

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27 Apr 2006
publication

Structural basis for broad DNA-specificity in integron recombination

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08 Dec 2005
publication

Integron cassette insertion: a recombination process involving a folded single strand substrate

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19 Aug 2005
publication

The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae

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01 Jul 2005
publication

Integron-associated antibiotic resistance and phylogenetic grouping of Escherichia coli isolates from healthy subjects free of recent antibiotic exposure

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01 Mar 2005
publication

A new family of mobilizable suicide plasmids based on broad host range R388 plasmid (IncW) and RP4 plasmid (IncPalpha) conjugative machineries and their cognate Escherichia coli host strains

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01 Mar 2005
publication

Comparative study of class 1 integron and Vibrio cholerae superintegron integrase activities

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01 Jul 2004
publication

A new family of conditional replicating plasmids and their cognate Escherichia coli host strains

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01 Oct 2003
publication

Erythromycin esterase gene ere(A) is located in a functional gene cassette in an unusual class 2 integron

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01 Mar 2003
publication

Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae

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01 Jul 2002
publication

The role of integrons in antibiotic resistance gene capture

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01 Mar 2002
publication

Bacterial resistance evolution by recruitment of super-integron gene cassettes

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