Mélanie Legrand is a permanent scientist in the Fungal Biology and Pathogenicity Unit. Mélanie Legrand has gained her Master degree at the University of Minnesota working on mating in the human fungal pathogens Candida albicans and Candida dubliniensis in the laboratory of Prof. Paul Magee. She has completed her PhD degree working on DNA repair in Candida albicans with Dr. David Kirkpatrick at the University of Minnesota. She joined the Unit of Fungal Biology and Pathogenicity Unit headed by Prof. Christophe d’Enfert at the Institut Pasteur to study the molecular mechanisms involved in maintenance of genome integrity in Candida albicans. She obtained a permanent INRA position in 2010.
She is interested in Candida albicans‘ general biology, genome dynamics and mating. Presently, she is leading a project on the identification of regulators of « Loss of Heterozygosity » in C. albicans. She also contributes to the C. albicans ORFeome project.
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2021Factors that influence bidirectional long-tract homozygosis due to double-strand break repair in Candida albicans., Genetics 2021 Mar; (): .
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2020The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives., FEMS Microbiol Rev 2020 Nov; (): .
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2020Use of CRISPR-Cas9 To Target Homologous Recombination Limits Transformation-Induced Genomic Changes in Candida albicans., mSphere 2020 09; 5(5): .
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2020Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans., Front Microbiol 2020 ; 11(): 591140.
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2019Candida albicans: An Emerging Yeast Model to Study Eukaryotic Genome Plasticity, Trends Genet. 2019 Apr;35(4):292-307.
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2019Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact, mSphere 2019 02;4(1).
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2018Generating genomic platforms to study Candida albicans pathogenesis., Nucleic Acids Res 2018 08; 46(14): 6935-6949.
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2016Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome, mBio 2016 10;7(5).
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2015A FACS-optimized screen identifies regulators of genome stability in Candida albicans, Eukaryotic Cell 2015 Mar;14(3):311-22.
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2014Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating, Fungal Genet. Biol. 2014 Dec;73:20-8.
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