Mélanie Legrand is a permanent scientist in the Fungal Biology and Pathogenicity Unit. Mélanie Legrand has gained her Master degree at the University of Minnesota working on mating in the human fungal pathogens Candida albicans and Candida dubliniensis in the laboratory of Prof. Paul Magee. She has completed her PhD degree working on DNA repair in Candida albicans with Dr. David Kirkpatrick at the University of Minnesota. She joined the Unit of Fungal Biology and Pathogenicity Unit headed by Prof. Christophe d’Enfert at the Institut Pasteur to study the molecular mechanisms involved in maintenance of genome integrity in Candida albicans. She obtained a permanent INRA position in 2010.
She is interested in Candida albicans‘ general biology, genome dynamics and mating. Presently, she is leading a project on the identification of regulators of « Loss of Heterozygosity » in C. albicans. She also contributes to the C. albicans ORFeome project.
Click to view graph
Connections
Click to view timeline
Timeline
Projects
Tools
Publications
Download-
2019Candida albicans: An Emerging Yeast Model to Study Eukaryotic Genome Plasticity, Trends Genet. 2019 Apr;35(4):292-307.
-
2019Identification of Recessive Lethal Alleles in the Diploid Genome of a Candida albicans Laboratory Strain Unveils a Potential Role of Repetitive Sequences in Buffering Their Deleterious Impact, mSphere 2019 Feb;4(1).
-
2018Generating genomic platforms to study Candida albicans pathogenesis, Nucleic Acids Res. 2018 Aug;46(14):6935-6949.
-
2016Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome, MBio 2016 Oct;7(5).
-
2015A FACS-optimized screen identifies regulators of genome stability in Candida albicans, Eukaryotic Cell 2015 Mar;14(3):311-22.
-
2014Targeted changes of the cell wall proteome influence Candida albicans ability to form single- and multi-strain biofilms, PLoS Pathog. 2014 Dec;10(12):e1004542.
-
2014Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating, Fungal Genet. Biol. 2014 Dec;73:20-8.
-
2013A study of the DNA damage checkpoint in Candida albicans: uncoupling of the functions of Rad53 in DNA repair, cell cycle regulation and genotoxic stress-induced polarized growth, Mol. Microbiol. 2014 Feb;91(3):452-71.
-
2012A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness, PLoS ONE 2012;7(9):e45912.
-
2012Modular gene over-expression strategies for Candida albicans, Methods Mol. Biol. 2012;845:227-44.
-
+View full list of publications