Dr. Sadri ZNAIDI is a biochemist (B.Sc., M.Sc. from the University of Sherbrooke, Canada) and molecular biologist (Ph.D., from the University of Montreal, Canada), with expertise in yeast genetics and functional genomics. He is currently a RIIP (Institut Pasteur International Network) Affiliate Program Fellow, with affiliations at the Institut Pasteur in Tunis and Paris. His current work focuses on the implementation of systems biology-oriented approaches to identify and characterize components of the biological circuitry involved in the interaction of Candida albicans with the host environment.
Candida albicans colonization of abiotic and biotic surfaces
Biofilms formed by C. albicans on indwelling devices play a major role in the persistence of nosocomial infections, largely because of their elevated tolerance to antifungals. The Fungal Biology and Pathogenicity Unit at Institut […]
Regulation of Candida albicans morphogenesis
The Fungal Biology and Pathogenicity Unit at Institut Pasteur is interested in the regulation of the yeast-to-hypha transition in C. albicans because of its role in biofilm formation and, more generally, in virulence. While […]
FunComPath is a network within the Infect-ERA programme (www.infect-era.eu). Infect-ERA is an ERA-Net on human infectious diseases funded under the EU 7th Research Framework Programme (2013 – 2016). It is a continuation of the […]
Current: RIIP Affiliate Program Fellow, Institut Pasteur in Tunis & Paris
2010 – 2015: Postdoctoral fellow, Institut Pasteur, Paris, France
2004 – 2010: Ph.D., Molecular Biology, University of Montreal, Canada
2002 – 2004: M.Sc., Biochemistry, Université de Sherbrooke, Canada
1999 – 2002: B.Sc., Biochemistry, Université de Sherbrooke, Canada
2020mSphere of Influence: Decoding Transcriptional Regulatory Networks To Illuminate the Mechanisms of Microbial Pathogenicity, mSphere 2020 Jan;5(1).
2018From Genes to Networks: The Regulatory Circuitry Controlling Candida albicans Morphogenesis, Curr. Top. Microbiol. Immunol. 2019;422:61-99.
2018Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut, Cell. Microbiol. 2018 Jul;:e12890.
2017The two-component response regulator Skn7 belongs to a network of transcription factors regulating morphogenesis in Candida albicans and independently limits morphogenesis-induced ROS accumulation, Mol. Microbiol. 2017 Jul;.
2016Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency, MBio 2016 Mar;7(2):e00331.
2014Targeted changes of the cell wall proteome influence Candida albicans ability to form single- and multi-strain biofilms, PLoS Pathog. 2014 Dec;10(12):e1004542.
2013A comprehensive functional portrait of two heat shock factor-type transcriptional regulators involved in Candida albicans morphogenesis and virulence, PLoS Pathog. 2013 Aug;9(8):e1003519.
2012A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness, PLoS ONE 2012;7(9):e45912.
2012A luciferase reporter for gene expression studies and dynamic imaging of superficial Candida albicans infections, Methods Mol. Biol. 2012;845:537-46.
2011Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans, Antimicrob. Agents Chemother. 2011 May;55(5):2212-23.
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