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© Institut Pasteur
Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Ongoing
5 Members

Trafficking and assembly of influenza virus genomic RNAs

Nadia Naffakh (PI)

A collaboration with the electron microscopy expert Cristina Risco (CSIC, Madrid) led us to propose a model in which the endoplasmic reticulum (ER) plays an essential role in the trafficking of newly synthesized viral […]
Project
Ongoing
5 Members

Molecular mechanism of transcription by influenza virus polymerase

Nadia Naffakh (PI)

In the frame of a collaboration with Stephen Cusack (EMBL Grenoble) we showed that the direct interaction of the influenza virus polymerase (FluPol) PA subunit to the phosphorylated C-terminal domain of the cellular RNA […]

Tools

Tool
Ongoing
2 Members

Engineered influenza viruses expressing a tagged polymerase subunit

Nadia Naffakh (PI)

To investigate the molecular processes involved in the synthesis, processing, and trafficking of viral mRNAs and genomic RNAs, we have developed original methods based on engineered viruses expressing a FluPol subunit protein tagged with an affinity […]
Tool
Ongoing
5 Members

High-throughput protein-protein interaction assay based on a split-luciferase

Yves Jacob (PI)

The coverage and robustness of protein-protein interactions (PPI) datasets can be markedly increased by combining orthogonal PPI assays. For this purpose we have recently developed two variations of our High-throughput Gaussia princeps Complementation Assay(HT-GPCA), […]

Publications

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