Trafficking and assembly of influenza virus genomic RNAs
A collaboration with the electron microscopy expert Cristina Risco (CSIC, Madrid) led us to propose a model in which the endoplasmic reticulum (ER) plays an essential role in the trafficking of newly synthesized viral […]
Molecular mechanism of transcription by influenza virus polymerase
In the frame of a collaboration with Stephen Cusack (EMBL Grenoble) we showed that the direct interaction of the influenza virus polymerase (FluPol) PA subunit to the phosphorylated C-terminal domain of the cellular RNA […]
Engineered influenza viruses expressing a tagged polymerase subunit
To investigate the molecular processes involved in the synthesis, processing, and trafficking of viral mRNAs and genomic RNAs, we have developed original methods based on engineered viruses expressing a FluPol subunit protein tagged with an affinity […]
High-throughput protein-protein interaction assay based on a split-luciferase
The coverage and robustness of protein-protein interactions (PPI) datasets can be markedly increased by combining orthogonal PPI assays. For this purpose we have recently developed two variations of our High-throughput Gaussia princeps Complementation Assay(HT-GPCA), […]
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