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Immune responses against tumors
Philippe Bousso (PI)
Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on […]
2021A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity., Sci Immunol 2021 Mar; 6(57): .
2021Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis., Sci Adv 2021 Feb; 7(8): .
2020Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment, Nature Cancer 2020 Mar 1(3):302-314.
2020Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment., Nat Cancer 2020 Mar; 1(3): 302-314.
2018A human immune system mouse model with robust lymph node development, Nat. Methods 2018 Aug;15(8):623-630.
2018Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division, J. Exp. Med. 2018 May;215(5):1481-1492.
2016Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies., Sci Rep 2016 10; 6(): 34382.
2016The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation, Immunity 2016 Jan;44(1):143-154.
2015In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity, Nat. Med. 2016 Jan;22(1):64-71.
2015Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest, Proc. Natl. Acad. Sci. U.S.A. 2015 Sep;112(39):12151-6.
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