Bruno Dupuy

Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]

Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]

The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]

Clostridium difficile is increasingly associated with infections in hospitals and in the community, and hypervirulent types are emerging. Six research groups from 5 countries undertook this project, aiming to use genomic approaches to study […]

Although  many clinically and ecologically relevant processes are known to be  performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in  aerobic conditions.  We use in vitro anaerobic culture systems […]

The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]

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COV2HTML is an interactive web interface, which is addressed to biologists, and allows performing both coverage visualization and analysis of NGS alignments performed on prokaryotic organisms (bacteria and phages). It combines two processes: a […]