Timeline
Claude Leclerc
Head of Structure
08 Jun 2018
publication
Mitochondrial reactive oxygen species regulate the induction of CD8 T cells by plasmacytoid dendritic cells
Read more08 Jun 2018
publication
Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells.
Read more01 Jun 2018
publication
Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling.
Read more09 Mar 2018
publication
Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling
Read more24 Apr 2017
01 Feb 2017
publication
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis
Read more01 Jan 2017
publication
Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate
Read more26 Dec 2016
publication
A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies
Read more20 Dec 2016
publication
Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate
Read more28 Jul 2016
publication
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection
Read more22 Jun 2016
14 May 2016
publication
B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer
Read more01 Mar 2016
publication
The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity.
Read more23 Nov 2015
08 Oct 2015
project
GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.
Read more08 Oct 2015
project
GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates
Read more07 Oct 2015
30 Sep 2015
project
A synthetic glycopeptide for anti-tumor immunotherapy: from design to first use in human
Read more26 Sep 2015
22 Sep 2015
publication
The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR
Read more15 Sep 2015
29 Jun 2015
publication
Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication
Read more15 Jun 2015
10 Apr 2015
publication
Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells
Read more18 Jul 2014
publication
Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach
Read more14 Jul 2014
publication
Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses
Read more27 Jun 2014
publication
Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming
Read more28 May 2014
publication
CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus
Read more20 Feb 2014
publication
Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings
Read more06 Jun 2013
publication
MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion
Read more21 Apr 2013
publication
Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer
Read more10 Jan 2013
publication
Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses
Read more06 Jan 2013
publication
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis
Read more01 Jul 2012
publication
Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses
Read more18 May 2012
publication
Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice
Read more09 May 2012
publication
The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences
Read more19 Apr 2012
publication
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential
Read more05 Apr 2012
publication
Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores
Read more02 Mar 2012
publication
Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses
Read more20 Feb 2012
publication
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation
Read more01 Jan 2012
publication
Spirituality and religion in outpatients with schizophrenia: a multi-site comparative study of Switzerland, Canada, and the United States
Read more02 Dec 2011
publication
Do personality traits matter when choosing a group therapy for early psychosis?
Read more05 Oct 2011
publication
Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin
Read more06 Jun 2011
publication
The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells
Read more15 Apr 2011
publication
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis
Read more01 Mar 2011
30 Dec 2010
publication
Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses
Read more15 Sep 2010
publication
Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis
Read more20 Aug 2010
publication
Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope
Read more18 Aug 2010
publication
Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant
Read more12 Aug 2010
publication
Personality traits in early psychosis: relationship with symptom and coping treatment outcomes
Read more11 Jun 2010
publication
The process of recovery of people with mental illness: the perspectives of patients, family members and care providers: part 1
Read more17 Apr 2010
23 Feb 2010
publication
Adenylate cyclase toxin translocates across target cell membrane without forming a pore
Read more12 Nov 2009
publication
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils
Read more10 Nov 2009
22 Sep 2009
publication
Religion and spirituality: how clinicians in quebec and geneva cope with the issue when faced with patients suffering from chronic psychosis
Read more15 Aug 2009
publication
The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells
Read more01 May 2009
01 Apr 2009
publication
Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide
Read more01 Dec 2008
publication
Group cognitive behavior therapy or social skills training for individuals with a recent onset of psychosis? Results of a randomized controlled trial
Read more15 Sep 2008
publication
Immobilized cytokines as biomaterials for manufacturing immune cell based vaccines
Read more12 Aug 2008
publication
Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation
Read more30 Jul 2008
publication
Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis
Read more10 Jul 2008
20 May 2008
publication
Treatment by CpG or Flt3-ligand does not affect mouse susceptibility to BSE prions
Read more04 Mar 2008
publication
Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis
Read more01 Feb 2008
publication
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
Read more15 Sep 2007
publication
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system
Read more01 Aug 2007
publication
Personality characteristics and attachment in first episode psychosis: impact on social functioning
Read more01 Aug 2007
publication
Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules
Read more23 May 2007
publication
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector
Read more07 May 2007
publication
Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells
Read more01 Apr 2007
05 Mar 2007
publication
TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help
Read more01 Mar 2007
publication
Intrusion errors in explicit memory: their differential relationship with clinical and social outcome in chronic schizophrenia
Read more15 Feb 2007
publication
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN
Read more15 Jan 2007
publication
The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo
Read more01 Dec 2006
publication
Carbohydrate antigens: synthesis aspects and immunological applications in cancer
Read more01 Nov 2006
16 Aug 2006
01 Jun 2006
publication
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection
Read more05 May 2006
01 May 2006
publication
Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells
Read more01 Apr 2006
publication
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis
Read more21 Feb 2006
publication
Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates
Read more31 Jan 2006
publication
Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination
Read more13 Jan 2006
publication
Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo
Read more01 Jan 2006
publication
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
Read more27 Sep 2005
publication
Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells
Read more01 Sep 2005
publication
Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines
Read more01 Aug 2005
publication
Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis
Read more27 Jul 2005
publication
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity
Read more01 May 2005
publication
Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids
Read more01 Apr 2005
publication
Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs
Read more15 Mar 2005
publication
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system
Read more15 Mar 2005
publication
Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal
Read more15 Jan 2005
publication
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein
Read more01 Jan 2005
16 Dec 2004
publication
Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo
Read more15 Nov 2004
publication
Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming
Read more01 Nov 2004
publication
Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis
Read more15 Aug 2004
publication
Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres
Read more01 Jul 2004
01 Jul 2004
publication
Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen
Read more04 Jun 2004
publication
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens
Read more27 May 2004
publication
Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation
Read more01 Apr 2004
publication
The adenylate cyclase toxin from Bordetella pertussis–a novel promising vehicle for antigen delivery to dendritic cells
Read more01 Apr 2004
publication
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
Read more01 Feb 2004
01 Dec 2003
publication
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes
Read more01 Dec 2003
publication
CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family
Read more01 Oct 2003
publication
The B subunit of Shiga toxin coupled to full-size antigenic protein elicits humoral and cell-mediated immune responses associated with a Th1-dominant polarization
Read more01 Oct 2003
01 Sep 2003
publication
[In-vivo dynamic changes of antigen presenting cells infected with recombinant attenuated Salmonella typhimurium expressing green fluorescent protein]
Read more01 Sep 2003
publication
In vivo, dendritic cells can cross-present virus-like particles using an endosome-to-cytosol pathway
Read more28 Jul 2003
publication
Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain
Read more14 Apr 2003
publication
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
Read more27 Mar 2003
01 Feb 2003
publication
The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response
Read more20 Jan 2003
publication
CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles
Read more01 Nov 2002
publication
In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.
Read more01 Jun 2002
publication
Induction of HLA-A2-restricted CTL responses by a tubular structure carrying human melanoma epitopes
Read more01 Jun 2002
20 May 2002
publication
CD8alpha- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8alpha and CD205 molecules
Read more01 Apr 2002
01 Mar 2002
publication
Efficient in vivo priming of specific cytotoxic T cell responses by neonatal dendritic cells
Read more01 Feb 2002
publication
Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.
Read more01 Feb 2002
publication
Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase
Read more31 Jan 2002
publication
Induction of protective antiviral cytotoxic T cells by a tubular structure capable of carrying large foreign sequences
Read more01 Jan 2000
publication
Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.
Read more01 Nov 1999
publication
mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.
Read more15 Feb 1999
publication
Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
Read more01 Nov 1998
publication