Timeline

Claude Leclerc
Head of Structure
08 Jun 2018
publication

Mitochondrial reactive oxygen species regulate the induction of CD8 T cells by plasmacytoid dendritic cells

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08 Jun 2018
publication

Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells.

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01 Jun 2018
publication

Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling.

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09 Mar 2018
publication

Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling

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24 Apr 2017
event

GPF Vaccinology day

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01 Feb 2017
publication

Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis

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26 Dec 2016
publication

A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies

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20 Dec 2016
publication

Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate

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28 Jul 2016
publication

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

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22 Jun 2016
project

Think tank: Cancer

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14 May 2016
publication

B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer

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04 Feb 2016
publication

The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity

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23 Nov 2015
project

Advanced Immunization Technologies (ADITEC)

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08 Oct 2015
project

GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.

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08 Oct 2015
project

GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates

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07 Oct 2015
program_project

Major Federating Program Vaccinology

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30 Sep 2015
project

A synthetic glycopeptide for anti-tumor immunotherapy: from design to first use in human

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26 Sep 2015
project

Comics on vaccination

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22 Sep 2015
publication

The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR

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15 Sep 2015
project

Clinical development of cancer vaccines

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29 Jun 2015
publication

Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication

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15 Jun 2015
project

Tumor immunity and preclinical development of cancer vaccines

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10 Apr 2015
publication

Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells

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18 Jul 2014
publication

Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach

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14 Jul 2014
publication

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses

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27 Jun 2014
publication

Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming

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28 May 2014
publication

CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus

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20 Feb 2014
publication

Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings

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06 Jun 2013
publication

MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion

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21 Apr 2013
publication

Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer

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10 Jan 2013
publication

Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses

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06 Jan 2013
publication

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

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01 Jul 2012
publication

Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses

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18 May 2012
publication

Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice

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09 May 2012
publication

The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences

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19 Apr 2012
publication

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential

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05 Apr 2012
publication

Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores

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02 Mar 2012
publication

Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses

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20 Feb 2012
publication

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

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01 Jan 2012
publication

Spirituality and religion in outpatients with schizophrenia: a multi-site comparative study of Switzerland, Canada, and the United States

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02 Dec 2011
publication

Do personality traits matter when choosing a group therapy for early psychosis?

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05 Oct 2011
publication

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin

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06 Jun 2011
publication

The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells

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15 Apr 2011
publication

ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis

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01 Mar 2011
publication

[Evaluation of the mental condition. How are you today?]

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30 Dec 2010
publication

Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses

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15 Sep 2010
publication

Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis

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20 Aug 2010
publication

Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope

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18 Aug 2010
publication

Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant

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12 Aug 2010
publication

Personality traits in early psychosis: relationship with symptom and coping treatment outcomes

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11 Jun 2010
publication

The process of recovery of people with mental illness: the perspectives of patients, family members and care providers: part 1

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17 Apr 2010
publication

Towards a rational approach to vaccine development

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23 Feb 2010
publication

Adenylate cyclase toxin translocates across target cell membrane without forming a pore

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12 Nov 2009
publication

Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils

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10 Nov 2009
publication

Change in delusions is associated with change in “jumping to conclusions”

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22 Sep 2009
publication

Religion and spirituality: how clinicians in quebec and geneva cope with the issue when faced with patients suffering from chronic psychosis

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15 Aug 2009
publication

The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells

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01 May 2009
publication

Developing a model of recovery in mental health

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01 Apr 2009
publication

Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide

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01 Dec 2008
publication

Group cognitive behavior therapy or social skills training for individuals with a recent onset of psychosis? Results of a randomized controlled trial

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15 Sep 2008
publication

Immobilized cytokines as biomaterials for manufacturing immune cell based vaccines

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12 Aug 2008
publication

Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation

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30 Jul 2008
publication

Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis

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10 Jul 2008
publication

Regulatory B and T cells in infections

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20 May 2008
publication

Treatment by CpG or Flt3-ligand does not affect mouse susceptibility to BSE prions

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04 Mar 2008
publication

Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis

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01 Feb 2008
publication

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

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15 Sep 2007
publication

Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system

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01 Aug 2007
publication

Personality characteristics and attachment in first episode psychosis: impact on social functioning

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01 Aug 2007
publication

Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules

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23 May 2007
publication

Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector

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07 May 2007
publication

Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells

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01 Apr 2007
publication

[New technologies for vaccine development]

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05 Mar 2007
publication

TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help

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01 Mar 2007
publication

Intrusion errors in explicit memory: their differential relationship with clinical and social outcome in chronic schizophrenia

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15 Feb 2007
publication

Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN

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15 Jan 2007
publication

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo

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01 Dec 2006
publication

Carbohydrate antigens: synthesis aspects and immunological applications in cancer

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01 Nov 2006
publication

[Analysis of in vitro delivering CD8+ T epitopes by attenuated bacteria]

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16 Aug 2006
publication

Fetal spleen stroma drives macrophage commitment

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01 Jun 2006
publication

High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection

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05 May 2006
publication

Do people with a first episode of psychosis differ in personality profiles?

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01 May 2006
publication

Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells

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01 Apr 2006
publication

An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis

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21 Feb 2006
publication

Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates

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31 Jan 2006
publication

Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination

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13 Jan 2006
publication

Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo

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01 Jan 2006
publication

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence

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27 Sep 2005
publication

Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells

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01 Sep 2005
publication

Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines

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01 Aug 2005
publication

Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis

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27 Jul 2005
publication

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity

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01 May 2005
publication

Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids

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01 Apr 2005
publication

Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs

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15 Mar 2005
publication

Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal

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15 Mar 2005
publication

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system

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15 Jan 2005
publication

Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein

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01 Jan 2005
publication

[Group interventions for people with refractory psychosis]

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16 Dec 2004
publication

Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo

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15 Nov 2004
publication

Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming

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01 Nov 2004
publication

Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis

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15 Aug 2004
publication

Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres

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15 Jul 2004
publication

A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates

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01 Jul 2004
publication

Neonatal adaptive immunity comes of age

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01 Jul 2004
publication

Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen

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04 Jun 2004
publication

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens

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27 May 2004
publication

Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation

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01 Apr 2004
publication

The adenylate cyclase toxin from Bordetella pertussis–a novel promising vehicle for antigen delivery to dendritic cells

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01 Apr 2004
publication

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6

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01 Feb 2004
publication

New tools for antigen delivery to the MHC class I pathway

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01 Dec 2003
publication

Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes

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01 Dec 2003
publication

CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family

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01 Oct 2003
publication

The B subunit of Shiga toxin coupled to full-size antigenic protein elicits humoral and cell-mediated immune responses associated with a Th1-dominant polarization

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01 Oct 2003
publication

New approaches in vaccine development

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01 Sep 2003
publication

In vivo, dendritic cells can cross-present virus-like particles using an endosome-to-cytosol pathway

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01 Sep 2003
publication

[In-vivo dynamic changes of antigen presenting cells infected with recombinant attenuated Salmonella typhimurium expressing green fluorescent protein]

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28 Jul 2003
publication

Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain

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14 Apr 2003
publication

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

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27 Mar 2003
publication

Ontogeny and innate properties of neonatal dendritic cells

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01 Feb 2003
publication

The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response

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20 Jan 2003
publication

CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles

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01 Nov 2002
publication

In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells

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01 Jun 2002
publication

Virus-like particles: a new family of delivery systems

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01 Jun 2002
publication

Induction of HLA-A2-restricted CTL responses by a tubular structure carrying human melanoma epitopes

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20 May 2002
publication

CD8alpha- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8alpha and CD205 molecules

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01 Apr 2002
publication

Challenges and issues in new vaccine development

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01 Mar 2002
publication

Efficient in vivo priming of specific cytotoxic T cell responses by neonatal dendritic cells

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01 Feb 2002
publication

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity

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01 Feb 2002
publication

Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase

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31 Jan 2002
publication

Induction of protective antiviral cytotoxic T cells by a tubular structure capable of carrying large foreign sequences

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