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© Research
Publication : Blood

TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Blood - 05 Mar 2007

Hervas-Stubbs S, Olivier A, Boisgerault F, Thieblemont N, Leclerc C

Link to Pubmed [PMID] – 17339421

Blood 2007 Jun;109(12):5318-26

We investigated whether Toll-like receptor ligands (TLR-Ls) can bypass the requirement for CD4(+) T-cell help in the induction of fully efficient memory CD8(+) T cells (cytotoxic T lymphocytes [CTLs]). “Helpless” CTLs were induced by a synthetic CD8(+) T-cell epitope administered with TLR3-L and TLR9-L, but not with TLR2/6-L, TLR4-L, or TLR7-L. The up-regulation of MHC-I and costimulatory molecules by dendritic cells following TLR stimulation was not sufficient for the priming of “helpless” CTLs, which depended essentially on the induction of a strong IFN-alpha/beta response. The “helpless” CTLs induced by TLR-Ls differentiated into fully functional memory CTLs able to proliferate as well as their “helped” counterparts upon challenge, in the absence of CD4(+) T-cell help.

http://www.ncbi.nlm.nih.gov/pubmed/17339421