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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Oct 2011
Ending Date
30
Sep 2017
Status
Ongoing
Members
3
Structures
3

About

We are member of the ADITEC Consortium, a collaborative research programme that aims to accelerate the development of novel and powerful immunisation technologies for the next generation of human vaccines. Scientists from 13 countries and 42 research partners collaborate in the Aditec project.
Aditec comprises some of the most competitive European research groups from universities, research institutions and biotech companies together with top US groups on systems biology and adjuvants. Different aspects of vaccination, from basic research, new technologies to clinical trials and public health, are covered.
Aditec started in October 2011, is a 6-year project and has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No280873.

Analysis of DC involvement in the induction of immune responses by Integrase-Defective Lentiviral Vectors (IDLV)

Recent reports highlight the potential for integrase-defective lentiviral vectors (IDLV) to be developed as vaccines due to their ability to elicit cell-mediated and humoral immune responses after intramuscular administration. This vector induces strong and long lasting immune responses. In the context of ADITEC, to decipher the mechanisms of induction of strong immune responses by IDLV, we are currently analyzing, in collaboration with A. Cara et D. Negri (Istituto Superiore di Sanità, Roma, Italy), the involvement of DC subsets in the induction of both innate and adaptive responses by IDLV using pDC and cDC deficient mice.

 

Fundings