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© Research
Publication : Vaccine

Induction of HLA-A2-restricted CTL responses by a tubular structure carrying human melanoma epitopes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 01 Jun 2002

Ghosh MK, Li CL, Fayolle C, Dadaglio G, Murphy A, Lemonnier FA, Roy P, Leclerc C

Link to Pubmed [PMID] – 12057601

Vaccine 2002 Jun;20(19-20):2463-73

Epitope-based vaccination strategies designed to induce strong tumor-specific CD8(+) T cell responses are being widely considered for cancer immunotherapy. Here, two recombinant tubular structures, NS1-Mela 1 and NS1-Mela 2, carrying, respectively two HLA-A2 epitopes derived from human melanoma antigens were constructed and their capability to induce CTL responses in vivo were studied in HLA-A2 transgenic mice. Strong CTL responses specific for GnT-V/NA 17-A and gp100 (154-162) epitopes were generated in HLA-A2 transgenic mice immunized by the construct NS1-Mela l carrying these two epitopes. The second construct NS1-Mela 2 carrying both Tyrosinase (369-377Da) and Melan-A/Mart-1 (27-35) epitopes induced a weak Tyrosinase-specific CTL response in mice but failed to induce specific CTL responses against the Melan-A/Mart-1 (27-35) epitope in the tested mice. Thus, recombinant tubular structures containing multiple tumoral epitopes may lead to new strategies for the induction of strong tumor-specific CTL responses in cancer patients.

http://www.ncbi.nlm.nih.gov/pubmed/12057601