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© Research
Publication : Infection and immunity

CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Dec 2003

Majlessi L, Rojas MJ, Brodin P, Leclerc C

Link to Pubmed [PMID] – 14638811

Infect. Immun. 2003 Dec;71(12):7173-7

Here we describe the identification of a new CD8(+)-T-cell epitope, the GYAGTLQSL nonamer, shared by the TB10.3 and TB10.4 proteins of the Mycobacterium tuberculosis ESAT-6 family. Cytotoxic T cells from mycobacterium-infected mice efficiently recognized this epitope. GYAGTLQSL-specific T-cell hybridomas, which were able to recognize Mycobacterium bovis BCG-infected macrophages, were generated and now allow investigation of mycobacterial-antigen processing through the major histocompatibility complex class I pathway.

http://www.ncbi.nlm.nih.gov/pubmed/14638811