Ligne de temps
Claude Leclerc
Responsable de Structure
08 juin 2018
publication
Mitochondrial reactive oxygen species regulate the induction of CD8 T cells by plasmacytoid dendritic cells
Lire plus08 juin 2018
publication
Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells.
Lire plus01 juin 2018
publication
Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling.
Lire plus09 mars 2018
publication
Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling
Lire plus24 avr. 2017
01 févr. 2017
publication
Colonization with Helicobacter is concomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis
Lire plus01 janv. 2017
publication
Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate
Lire plus26 déc. 2016
publication
A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies
Lire plus20 déc. 2016
publication
Large-scale synthesis and structural analysis of a synthetic glycopeptide dendrimer as an anti-cancer vaccine candidate
Lire plus28 juil. 2016
publication
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection
Lire plus22 juin 2016
14 mai 2016
publication
B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer
Lire plus01 mars 2016
publication
The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity.
Lire plus23 nov. 2015
08 oct. 2015
project
GPF Vaccinology Call 1: Open call for new ideas for cutting-edge science investigations in vaccinology.
Lire plus08 oct. 2015
project
GPF Vaccinology Call 2: Accelerating Preclinical Development of Vaccine Candidates
Lire plus07 oct. 2015
30 sept. 2015
project
A synthetic glycopeptide for anti-tumor immunotherapy: from design to first use in human
Lire plus26 sept. 2015
22 sept. 2015
publication
The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR
Lire plus15 sept. 2015
29 juin 2015
publication
Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication
Lire plus15 juin 2015
10 avr. 2015
publication
Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells
Lire plus18 juil. 2014
publication
Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach
Lire plus14 juil. 2014
publication
Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses
Lire plus27 juin 2014
publication
Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming
Lire plus28 mai 2014
publication
CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus
Lire plus20 févr. 2014
publication
Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings
Lire plus06 juin 2013
publication
MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion
Lire plus21 avr. 2013
publication
Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer
Lire plus10 janv. 2013
publication
Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses
Lire plus06 janv. 2013
publication
Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis
Lire plus01 juil. 2012
publication
Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses
Lire plus18 mai 2012
publication
Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice
Lire plus09 mai 2012
publication
The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences
Lire plus19 avr. 2012
publication
Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential
Lire plus05 avr. 2012
publication
Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores
Lire plus02 mars 2012
publication
Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses
Lire plus20 févr. 2012
publication
Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation
Lire plus01 janv. 2012
publication
Spirituality and religion in outpatients with schizophrenia: a multi-site comparative study of Switzerland, Canada, and the United States
Lire plus02 déc. 2011
publication
Do personality traits matter when choosing a group therapy for early psychosis?
Lire plus05 oct. 2011
publication
Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin
Lire plus06 juin 2011
publication
The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells
Lire plus15 avr. 2011
publication
ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis
Lire plus01 mars 2011
30 déc. 2010
publication
Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses
Lire plus15 sept. 2010
publication
Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis
Lire plus20 août 2010
publication
Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope
Lire plus18 août 2010
publication
Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant
Lire plus12 août 2010
publication
Personality traits in early psychosis: relationship with symptom and coping treatment outcomes
Lire plus11 juin 2010
publication
The process of recovery of people with mental illness: the perspectives of patients, family members and care providers: part 1
Lire plus17 avr. 2010
23 févr. 2010
publication
Adenylate cyclase toxin translocates across target cell membrane without forming a pore
Lire plus12 nov. 2009
publication
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils
Lire plus10 nov. 2009
22 sept. 2009
publication
Religion and spirituality: how clinicians in quebec and geneva cope with the issue when faced with patients suffering from chronic psychosis
Lire plus15 août 2009
publication
The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells
Lire plus01 mai 2009
01 avr. 2009
publication
Induction of a melanoma-specific antibody response by a monovalent, but not a divalent, synthetic GM2 neoglycopeptide
Lire plus01 déc. 2008
publication
Group cognitive behavior therapy or social skills training for individuals with a recent onset of psychosis? Results of a randomized controlled trial
Lire plus15 sept. 2008
publication
Immobilized cytokines as biomaterials for manufacturing immune cell based vaccines
Lire plus12 août 2008
publication
Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation
Lire plus30 juil. 2008
publication
Effect of attenuation of Treg during BCG immunization on anti-mycobacterial Th1 responses and protection against Mycobacterium tuberculosis
Lire plus10 juil. 2008
20 mai 2008
publication
Treatment by CpG or Flt3-ligand does not affect mouse susceptibility to BSE prions
Lire plus04 mars 2008
publication
Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis
Lire plus01 févr. 2008
publication
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
Lire plus15 sept. 2007
publication
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system
Lire plus01 août 2007
publication
Personality characteristics and attachment in first episode psychosis: impact on social functioning
Lire plus01 août 2007
publication
Inhibition of phagosome maturation by mycobacteria does not interfere with presentation of mycobacterial antigens by MHC molecules
Lire plus23 mai 2007
publication
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector
Lire plus07 mai 2007
publication
Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells
Lire plus01 avr. 2007
05 mars 2007
publication
TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help
Lire plus01 mars 2007
publication
Intrusion errors in explicit memory: their differential relationship with clinical and social outcome in chronic schizophrenia
Lire plus15 févr. 2007
publication
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN
Lire plus15 janv. 2007
publication
The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo
Lire plus01 déc. 2006
publication
Carbohydrate antigens: synthesis aspects and immunological applications in cancer
Lire plus01 nov. 2006
16 août 2006
01 juin 2006
publication
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection
Lire plus05 mai 2006
01 mai 2006
publication
Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells
Lire plus01 avr. 2006
publication
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis
Lire plus21 févr. 2006
publication
Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates
Lire plus31 janv. 2006
publication
Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination
Lire plus13 janv. 2006
publication
Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo
Lire plus01 janv. 2006
publication
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
Lire plus27 sept. 2005
publication
Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells
Lire plus01 sept. 2005
publication
Chemoselective assembly and immunological evaluation of multiepitopic glycoconjugates bearing clustered Tn antigen as synthetic anticancer vaccines
Lire plus01 août 2005
publication
Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis
Lire plus27 juil. 2005
publication
Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity
Lire plus01 mai 2005
publication
Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids
Lire plus01 avr. 2005
publication
Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs
Lire plus15 mars 2005
publication
Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system
Lire plus15 mars 2005
publication
Cross-priming of T cell responses by synthetic microspheres carrying a CD8+ T cell epitope requires an adjuvant signal
Lire plus15 janv. 2005
publication
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein
Lire plus01 janv. 2005
16 déc. 2004
publication
Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo
Lire plus15 nov. 2004
publication
Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming
Lire plus01 nov. 2004
publication
Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis
Lire plus15 août 2004
publication
Partial activation of neonatal CD11c+ dendritic cells and induction of adult-like CD8+ cytotoxic T cell responses by synthetic microspheres
Lire plus01 juil. 2004
01 juil. 2004
publication
Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen
Lire plus04 juin 2004
publication
Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens
Lire plus27 mai 2004
publication
Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation
Lire plus01 avr. 2004
publication
The adenylate cyclase toxin from Bordetella pertussis–a novel promising vehicle for antigen delivery to dendritic cells
Lire plus01 avr. 2004
publication
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
Lire plus01 févr. 2004
01 déc. 2003
publication
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes
Lire plus01 déc. 2003
publication
CD8+-T-cell responses of Mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family
Lire plus01 oct. 2003
publication
The B subunit of Shiga toxin coupled to full-size antigenic protein elicits humoral and cell-mediated immune responses associated with a Th1-dominant polarization
Lire plus01 oct. 2003
01 sept. 2003
publication
[In-vivo dynamic changes of antigen presenting cells infected with recombinant attenuated Salmonella typhimurium expressing green fluorescent protein]
Lire plus01 sept. 2003
publication
In vivo, dendritic cells can cross-present virus-like particles using an endosome-to-cytosol pathway
Lire plus28 juil. 2003
publication
Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain
Lire plus14 avr. 2003
publication
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
Lire plus27 mars 2003
01 févr. 2003
publication
The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response
Lire plus20 janv. 2003
publication
CD4-independent protective cytotoxic T cells induced in early life by a non-replicative delivery system based on virus-like particles
Lire plus01 nov. 2002
publication
In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.
Lire plus01 juin 2002
publication
Induction of HLA-A2-restricted CTL responses by a tubular structure carrying human melanoma epitopes
Lire plus01 juin 2002
20 mai 2002
publication
CD8alpha- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8alpha and CD205 molecules
Lire plus01 avr. 2002
01 mars 2002
publication
Efficient in vivo priming of specific cytotoxic T cell responses by neonatal dendritic cells
Lire plus01 févr. 2002
publication
Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.
Lire plus01 févr. 2002
publication
Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase
Lire plus31 janv. 2002
publication
Induction of protective antiviral cytotoxic T cells by a tubular structure capable of carrying large foreign sequences
Lire plus01 janv. 2000
publication
Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.
Lire plus01 nov. 1999
publication
mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.
Lire plus15 févr. 1999
publication
Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
Lire plus01 nov. 1998
publication