Timeline
Brigitte Gicquel
Permanent Researcher
11 Jan 2023
publication
SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.
Read more04 May 2020
publication
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Read more28 Aug 2017
publication
Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis
Read more28 Jul 2015
28 Jul 2015
09 Jun 2015
09 Jun 2015
20 Mar 2015
publication
bacterial infection drives the expression dynamics of microRNAs and their isomiRs
Read more25 Jul 2014
05 Mar 2014
publication
Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis
Read more30 Jan 2014
publication
A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection
Read more17 Aug 2013
publication
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials
Read more12 Apr 2013
publication
Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis
Read more01 Apr 2013
08 Jan 2013
publication
High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth
Read more13 Dec 2012
publication
Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic
Read more30 Oct 2012
publication
The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence
Read more21 Sep 2012
publication
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone
Read more07 Aug 2012
publication
Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system
Read more25 Jul 2012
publication
‘Z(S)-MDR-TB’ versus ‘Z(R)-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility
Read more04 Jun 2012
publication
An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection
Read more29 Feb 2012
publication
After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection
Read more30 Jan 2012
11 Jan 2012
publication
Combination of single nucleotide polymorphism and variable-number tandem repeats for genotyping a homogenous population of Mycobacterium tuberculosis Beijing strains in China
Read more10 Jan 2012
publication
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
Read more01 Jan 2012
publication
Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.
Read more23 Oct 2011
publication
Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection
Read more28 Sep 2011
publication
Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes
Read more15 Sep 2011
publication
Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages
Read more07 Jun 2011
publication
Genetic analysis of new 16S rRNA mutations conferring aminoglycoside resistance in Mycobacterium abscessus
Read more01 May 2011
publication
Spoligotyping of clinical Mycobacterium tuberculosis isolates from the state of Minas Gerais, Brazil
Read more01 Mar 2011
07 Feb 2011
publication
A first assessment of the genetic diversity of Mycobacterium tuberculosis complex in Cambodia
Read more20 Jan 2011
publication
Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from polymorphisms in genes involved in DNA replication, recombination and repair
Read more20 Jan 2011
publication
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237
Read more28 Oct 2010
publication
Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis
Read more25 Oct 2010
publication
Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes
Read more24 Sep 2010
publication
Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages
Read more09 Sep 2010
publication
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
Read more17 Aug 2010
publication
An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages
Read more17 Jul 2010
publication
Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method
Read more12 May 2010
publication
Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar
Read more25 Feb 2010
publication
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ
Read more04 Aug 2009
17 Jul 2009
publication
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
Read more01 May 2009
15 Apr 2009
publication
MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques
Read more06 Nov 2008
publication
Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity
Read more23 Oct 2008
publication
PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence
Read more18 Sep 2008
publication
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice
Read more01 Sep 2008
29 Aug 2008
publication
The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv
Read more14 Aug 2008
publication
Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice
Read more01 Jul 2008
01 Jul 2008
publication
The evolution of drug resistance in Mycobacterium tuberculosis: from a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population
Read more06 Feb 2008
publication
Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis
Read more01 Feb 2008
publication
Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice
Read more01 Feb 2008
publication
Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials
Read more01 Feb 2008
publication
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
Read more30 Jan 2008
publication
Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family
Read more02 Jan 2008
publication
Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
Read more01 Jan 2008
publication
Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics
Read more05 Oct 2007
publication
Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients
Read more26 Jul 2007
publication
T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals
Read more19 Jul 2007
publication
Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis
Read more01 Jun 2007
publication
Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli
Read more16 May 2007
publication
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria
Read more16 May 2007
publication
A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution
Read more01 Jan 2007
publication
Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis
Read more20 Dec 2006
15 Dec 2006
publication
Modification of the mycobacteriophage Ms6 attP core allows the integration of multiple vectors into different tRNAala T-loops in slow- and fast-growing mycobacteria
Read more04 Dec 2006
publication
Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility
Read more01 Dec 2006
publication
Humoral and cellular immune responses in sheep immunized with a 22 kilodalton exported protein of Mycobacterium avium subspecies paratuberculosis
Read more09 Oct 2006
publication
Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages
Read more09 Oct 2006
publication
Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities
Read more15 Sep 2006
publication
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth
Read more01 Sep 2006
publication
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic
Read more31 Aug 2006
publication
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase
Read more31 Jul 2006
30 May 2006
publication
Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives
Read more24 Apr 2006
publication
The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs
Read more05 Apr 2006
publication
DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population
Read more16 Mar 2006
publication
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis
Read more06 Mar 2006
publication
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis
Read more13 Jan 2006
publication
Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes
Read more03 Jan 2006
publication
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis
Read more01 Jan 2006
publication
Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients
Read more15 Dec 2005
publication
Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity
Read more02 Dec 2005
publication
The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis
Read more15 Nov 2005
publication
DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis
Read more01 Nov 2005
publication
Identification and characterization of an immunogenic 22 kDa exported protein of Mycobacterium avium subspecies paratuberculosis
Read more06 Oct 2005
29 Sep 2005
publication
The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region
Read more10 May 2005
publication
Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes
Read more20 Jan 2005
publication
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis
Read more01 Jan 2005
publication
Changes of the phagosomal elemental concentrations by Mycobacterium tuberculosis Mramp
Read more01 Jan 2005
publication
Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection
Read more01 Jun 2004
publication
Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge
Read more01 Apr 2004
publication
The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis
Read more01 Mar 2004
publication
Production of phthiocerol dimycocerosates protects Mycobacterium tuberculosis from the cidal activity of reactive nitrogen intermediates produced by macrophages and modulates the early immune response to infection
Read more16 Feb 2004
publication
The Erp protein is anchored at the surface by a carboxy-terminal hydrophobic domain and is important for cell-wall structure in Mycobacterium smegmatis
Read more01 Feb 2004
publication
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
Read more26 Jan 2004
publication
Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C
Read more22 Dec 2003
publication
Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine
Read more01 Oct 2003
publication
Mucosal administration of three recombinant Mycobacterium bovis BCG-SIVmac251 strains to cynomolgus macaques induces rectal IgAs and boosts systemic cellular immune responses that are primed by intradermal vaccination
Read more01 Aug 2003
publication
Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs
Read more08 Jul 2003
publication
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species
Read more01 Jul 2003
publication
Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family
Read more01 Jul 2003
publication
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis
Read more25 Jun 2003
publication
Mycobacterium tuberculosis Rv1395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation
Read more01 Jun 2003
publication
How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis
Read more01 Jun 2003
01 Jun 2003
publication
Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells
Read more01 Feb 2003
publication
The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response
Read more01 Jan 2003
publication
The allele encoding the mycobacterial Erp protein affects lung disease in mice
Read more01 Jan 2003
publication
DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells
Read more20 Dec 2002
publication
The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan
Read more01 Nov 2002
publication
Extrapulmonary and pulmonary tuberculosis in antananarivo (madagascar): high clustering rate in female patients
Read more01 Oct 2002
01 Aug 2002
publication
Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice
Read more01 Jul 2002
14 Jun 2002
publication
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria
Read more01 May 2002
publication
Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis
Read more01 May 2002
publication
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis
Read more01 Feb 2002
publication
Signal-sequence-independent secretion of the staphylococcal nuclease in Mycobacterium smegmatis
Read more01 Feb 2002
publication