Timeline

Brigitte Gicquel
Head of Structure
28 Aug 2017
publication

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

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28 Jul 2015
project

Antibiotic resistances and drug screening

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28 Jul 2015
project

Nanotherapeutics for Antibiotic Resistant Emerging Bacterial pathogens

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09 Jun 2015
project

Horizontal gene transfer

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09 Jun 2015
project

The two-component system PhoP/PhoQ

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09 Jun 2015
project

DNA Repair and Evolution

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20 Mar 2015
publication

bacterial infection drives the expression dynamics of microRNAs and their isomiRs

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25 Jul 2014
publication

Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice

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05 Mar 2014
publication

Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis

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30 Jan 2014
publication

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection

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17 Aug 2013
publication

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

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12 Apr 2013
publication

Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis

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01 Apr 2013
publication

Systems approach to tuberculosis vaccine development

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08 Jan 2013
publication

High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth

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13 Dec 2012
publication

Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic

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30 Oct 2012
publication

The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence

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21 Sep 2012
publication

A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone

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07 Aug 2012
publication

Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system

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25 Jul 2012
publication

‘Z(S)-MDR-TB’ versus ‘Z(R)-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

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14 Jun 2012
publication

Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta

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04 Jun 2012
publication

An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection

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29 Feb 2012
publication

After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection

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30 Jan 2012
publication

Mycobacterium abscessus: a new antibiotic nightmare

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11 Jan 2012
publication

Combination of single nucleotide polymorphism and variable-number tandem repeats for genotyping a homogenous population of Mycobacterium tuberculosis Beijing strains in China

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10 Jan 2012
publication

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

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23 Oct 2011
publication

Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection

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28 Sep 2011
publication

Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes

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15 Sep 2011
publication

Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages

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07 Jun 2011
publication

Genetic analysis of new 16S rRNA mutations conferring aminoglycoside resistance in Mycobacterium abscessus

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01 May 2011
publication

Spoligotyping of clinical Mycobacterium tuberculosis isolates from the state of Minas Gerais, Brazil

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01 Mar 2011
publication

New tuberculosis vaccines

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07 Feb 2011
publication

A first assessment of the genetic diversity of Mycobacterium tuberculosis complex in Cambodia

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20 Jan 2011
publication

Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from polymorphisms in genes involved in DNA replication, recombination and repair

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20 Jan 2011
publication

Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237

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28 Oct 2010
publication

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis

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25 Oct 2010
publication

Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes

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24 Sep 2010
publication

Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages

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09 Sep 2010
publication

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling

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17 Aug 2010
publication

An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages

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17 Jul 2010
publication

Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method

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12 May 2010
publication

Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar

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25 Feb 2010
publication

Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ

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21 Sep 2009
publication

A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis

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04 Aug 2009
publication

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

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17 Jul 2009
publication

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

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01 May 2009
publication

DNA repair in Mycobacterium tuberculosis revisited

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15 Apr 2009
publication

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques

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06 Nov 2008
publication

Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity

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31 Oct 2008
publication

Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-gamma producing T-cells

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23 Oct 2008
publication

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence

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18 Sep 2008
publication

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice

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01 Sep 2008
publication

Tuberculosis: in it for the long haul

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29 Aug 2008
publication

The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv

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14 Aug 2008
publication

Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice

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01 Jul 2008
publication

Horizontally acquired genomic islands in the tubercle bacilli

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01 Jul 2008
publication

The evolution of drug resistance in Mycobacterium tuberculosis: from a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population

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06 Feb 2008
publication

Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis

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01 Feb 2008
publication

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

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01 Feb 2008
publication

Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice

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01 Feb 2008
publication

Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials

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30 Jan 2008
publication

Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family

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02 Jan 2008
publication

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages

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01 Jan 2008
publication

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics

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07 Dec 2007
publication

A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra

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05 Oct 2007
publication

Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients

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26 Jul 2007
publication

T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals

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19 Jul 2007
publication

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis

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01 Jun 2007
publication

Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli

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16 May 2007
publication

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

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16 May 2007
publication

A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution

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01 Jan 2007
publication

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

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20 Dec 2006
publication

Is adipose tissue a place for Mycobacterium tuberculosis persistence?

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15 Dec 2006
publication

Modification of the mycobacteriophage Ms6 attP core allows the integration of multiple vectors into different tRNAala T-loops in slow- and fast-growing mycobacteria

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04 Dec 2006
publication

Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility

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01 Dec 2006
publication

Humoral and cellular immune responses in sheep immunized with a 22 kilodalton exported protein of Mycobacterium avium subspecies paratuberculosis

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09 Oct 2006
publication

Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages

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09 Oct 2006
publication

Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities

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15 Sep 2006
publication

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

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01 Sep 2006
publication

Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic

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31 Aug 2006
publication

Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase

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31 Jul 2006
publication

Towards a crucial role for DC-SIGN in tuberculosis and beyond

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30 May 2006
publication

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives

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24 Apr 2006
publication

The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs

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05 Apr 2006
publication

DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population

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16 Mar 2006
publication

LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis

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06 Mar 2006
publication

Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis

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13 Jan 2006
publication

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes

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03 Jan 2006
publication

Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis

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01 Jan 2006
publication

Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients

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15 Dec 2005
publication

Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity

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02 Dec 2005
publication

The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis

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15 Nov 2005
publication

DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis

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01 Nov 2005
publication

Identification and characterization of an immunogenic 22 kDa exported protein of Mycobacterium avium subspecies paratuberculosis

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06 Oct 2005
publication

p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis

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29 Sep 2005
publication

The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region

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10 May 2005
publication

Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes

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20 Jan 2005
publication

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

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01 Jan 2005
publication

Changes of the phagosomal elemental concentrations by Mycobacterium tuberculosis Mramp

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01 Jan 2005
publication

Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection

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01 Jun 2004
publication

Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge

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01 Apr 2004
publication

The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis

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01 Mar 2004
publication

Production of phthiocerol dimycocerosates protects Mycobacterium tuberculosis from the cidal activity of reactive nitrogen intermediates produced by macrophages and modulates the early immune response to infection

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16 Feb 2004
publication

The Erp protein is anchored at the surface by a carboxy-terminal hydrophobic domain and is important for cell-wall structure in Mycobacterium smegmatis

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01 Feb 2004
publication

TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection

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26 Jan 2004
publication

Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C

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22 Dec 2003
publication

Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine

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01 Oct 2003
publication

Mucosal administration of three recombinant Mycobacterium bovis BCG-SIVmac251 strains to cynomolgus macaques induces rectal IgAs and boosts systemic cellular immune responses that are primed by intradermal vaccination

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01 Aug 2003
publication

Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs

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08 Jul 2003
publication

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species

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01 Jul 2003
publication

Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family

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01 Jul 2003
publication

Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis

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25 Jun 2003
publication

Mycobacterium tuberculosis Rv1395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation

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01 Jun 2003
publication

Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells

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01 Jun 2003
publication

[DC-SIGN, a key receptor of Mycobacterium tuberculosis?]

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01 Jun 2003
publication

How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis

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01 Feb 2003
publication

The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response

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01 Jan 2003
publication

The allele encoding the mycobacterial Erp protein affects lung disease in mice

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01 Jan 2003
publication

DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells

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20 Dec 2002
publication

The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan

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01 Nov 2002
publication

Extrapulmonary and pulmonary tuberculosis in antananarivo (madagascar): high clustering rate in female patients

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01 Oct 2002
publication

Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure

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01 Aug 2002
publication

Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice

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01 Jul 2002
publication

Phospholipases C are involved in the virulence of Mycobacterium tuberculosis

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14 Jun 2002
publication

Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria

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01 May 2002
publication

Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis

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01 May 2002
publication

Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis

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01 Feb 2002
publication

Signal-sequence-independent secretion of the staphylococcal nuclease in Mycobacterium smegmatis

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01 Feb 2002
publication

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity

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