Timeline

Brigitte Gicquel
Permanent Researcher
02 Oct 2024
course

Tuberculosis

Read more
11 Jan 2023
publication

SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.

Read more
04 May 2020
publication

The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection

Read more
28 Aug 2017
publication

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis

Read more
28 Jul 2015
project

Antibiotic resistances and drug screening

Read more
28 Jul 2015
project

Nanotherapeutics for Antibiotic Resistant Emerging Bacterial pathogens

Read more
09 Jun 2015
project

The two-component system PhoP/PhoQ

Read more
09 Jun 2015
project

DNA Repair and Evolution

Read more
20 Mar 2015
publication

bacterial infection drives the expression dynamics of microRNAs and their isomiRs

Read more
25 Jul 2014
publication

Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice

Read more
05 Mar 2014
publication

Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis

Read more
30 Jan 2014
publication

A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection

Read more
17 Aug 2013
publication

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

Read more
12 Apr 2013
publication

Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis

Read more
01 Apr 2013
publication

Systems approach to tuberculosis vaccine development

Read more
08 Jan 2013
publication

High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth

Read more
13 Dec 2012
publication

Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic

Read more
30 Oct 2012
publication

The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence

Read more
21 Sep 2012
publication

A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone

Read more
07 Aug 2012
publication

Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system

Read more
25 Jul 2012
publication

‘Z(S)-MDR-TB’ versus ‘Z(R)-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

Read more
04 Jun 2012
publication

An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection

Read more
29 Feb 2012
publication

After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection

Read more
30 Jan 2012
publication

Mycobacterium abscessus: a new antibiotic nightmare

Read more
11 Jan 2012
publication

Combination of single nucleotide polymorphism and variable-number tandem repeats for genotyping a homogenous population of Mycobacterium tuberculosis Beijing strains in China

Read more
10 Jan 2012
publication

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

Read more
01 Jan 2012
publication

Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.

Read more
23 Oct 2011
publication

Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection

Read more
28 Sep 2011
publication

Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes

Read more
15 Sep 2011
publication

Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages

Read more
07 Jun 2011
publication

Genetic analysis of new 16S rRNA mutations conferring aminoglycoside resistance in Mycobacterium abscessus

Read more
01 May 2011
publication

Spoligotyping of clinical Mycobacterium tuberculosis isolates from the state of Minas Gerais, Brazil

Read more
01 Mar 2011
publication

New tuberculosis vaccines

Read more
07 Feb 2011
publication

A first assessment of the genetic diversity of Mycobacterium tuberculosis complex in Cambodia

Read more
20 Jan 2011
publication

Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from polymorphisms in genes involved in DNA replication, recombination and repair

Read more
20 Jan 2011
publication

Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237

Read more
28 Oct 2010
publication

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis

Read more
25 Oct 2010
publication

Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes

Read more
24 Sep 2010
publication

Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages

Read more
09 Sep 2010
publication

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling

Read more
17 Aug 2010
publication

An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages

Read more
17 Jul 2010
publication

Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method

Read more
12 May 2010
publication

Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar

Read more
25 Feb 2010
publication

Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ

Read more
04 Aug 2009
publication

AftD, a novel essential arabinofuranosyltransferase from mycobacteria

Read more
17 Jul 2009
publication

Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

Read more
01 May 2009
publication

DNA repair in Mycobacterium tuberculosis revisited

Read more
15 Apr 2009
publication

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques

Read more
06 Nov 2008
publication

Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity

Read more
23 Oct 2008
publication

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence

Read more
18 Sep 2008
publication

Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice

Read more
01 Sep 2008
publication

Tuberculosis: in it for the long haul

Read more
29 Aug 2008
publication

The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv

Read more
14 Aug 2008
publication

Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice

Read more
01 Jul 2008
publication

Horizontally acquired genomic islands in the tubercle bacilli

Read more
01 Jul 2008
publication

The evolution of drug resistance in Mycobacterium tuberculosis: from a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population

Read more
06 Feb 2008
publication

Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis

Read more
01 Feb 2008
publication

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

Read more
01 Feb 2008
publication

Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice

Read more
01 Feb 2008
publication

Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials

Read more
30 Jan 2008
publication

Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family

Read more
02 Jan 2008
publication

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages

Read more
01 Jan 2008
publication

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics

Read more
05 Oct 2007
publication

Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients

Read more
26 Jul 2007
publication

T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals

Read more
19 Jul 2007
publication

Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis

Read more
01 Jun 2007
publication

Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli

Read more
16 May 2007
publication

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria

Read more
16 May 2007
publication

A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution

Read more
01 Jan 2007
publication

Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis

Read more
20 Dec 2006
publication

Is adipose tissue a place for Mycobacterium tuberculosis persistence?

Read more
15 Dec 2006
publication

Modification of the mycobacteriophage Ms6 attP core allows the integration of multiple vectors into different tRNAala T-loops in slow- and fast-growing mycobacteria

Read more
04 Dec 2006
publication

Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility

Read more
01 Dec 2006
publication

Humoral and cellular immune responses in sheep immunized with a 22 kilodalton exported protein of Mycobacterium avium subspecies paratuberculosis

Read more
09 Oct 2006
publication

Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages

Read more
09 Oct 2006
publication

Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities

Read more
15 Sep 2006
publication

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth

Read more
01 Sep 2006
publication

Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic

Read more
31 Aug 2006
publication

Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase

Read more
31 Jul 2006
publication

Towards a crucial role for DC-SIGN in tuberculosis and beyond

Read more
30 May 2006
publication

Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives

Read more
24 Apr 2006
publication

The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs

Read more
05 Apr 2006
publication

DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population

Read more
16 Mar 2006
publication

LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis

Read more
06 Mar 2006
publication

Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis

Read more
13 Jan 2006
publication

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes

Read more
03 Jan 2006
publication

Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis

Read more
01 Jan 2006
publication

Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients

Read more
15 Dec 2005
publication

Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity

Read more
02 Dec 2005
publication

The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis

Read more
15 Nov 2005
publication

DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis

Read more
01 Nov 2005
publication

Identification and characterization of an immunogenic 22 kDa exported protein of Mycobacterium avium subspecies paratuberculosis

Read more
06 Oct 2005
publication

p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis

Read more
29 Sep 2005
publication

The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region

Read more
10 May 2005
publication

Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes

Read more
20 Jan 2005
publication

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

Read more
01 Jan 2005
publication

Changes of the phagosomal elemental concentrations by Mycobacterium tuberculosis Mramp

Read more
01 Jan 2005
publication

Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection

Read more
01 Jun 2004
publication

Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge

Read more
01 Apr 2004
publication

The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis

Read more
01 Mar 2004
publication

Production of phthiocerol dimycocerosates protects Mycobacterium tuberculosis from the cidal activity of reactive nitrogen intermediates produced by macrophages and modulates the early immune response to infection

Read more
16 Feb 2004
publication

The Erp protein is anchored at the surface by a carboxy-terminal hydrophobic domain and is important for cell-wall structure in Mycobacterium smegmatis

Read more
01 Feb 2004
publication

TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection

Read more
26 Jan 2004
publication

Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C

Read more
22 Dec 2003
publication

Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine

Read more
01 Oct 2003
publication

Mucosal administration of three recombinant Mycobacterium bovis BCG-SIVmac251 strains to cynomolgus macaques induces rectal IgAs and boosts systemic cellular immune responses that are primed by intradermal vaccination

Read more
01 Aug 2003
publication

Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs

Read more
08 Jul 2003
publication

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species

Read more
01 Jul 2003
publication

Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family

Read more
01 Jul 2003
publication

Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis

Read more
25 Jun 2003
publication

Mycobacterium tuberculosis Rv1395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation

Read more
01 Jun 2003
publication

[DC-SIGN, a key receptor of Mycobacterium tuberculosis?]

Read more
01 Jun 2003
publication

Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells

Read more
01 Jun 2003
publication

How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis

Read more
01 Feb 2003
publication

The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response

Read more
01 Jan 2003
publication

The allele encoding the mycobacterial Erp protein affects lung disease in mice

Read more
01 Jan 2003
publication

DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells

Read more
20 Dec 2002
publication

The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan

Read more
01 Nov 2002
publication

Extrapulmonary and pulmonary tuberculosis in antananarivo (madagascar): high clustering rate in female patients

Read more
01 Oct 2002
publication

Mycobacterium tuberculosis phoP mutant: lipoarabinomannan molecular structure

Read more
01 Aug 2002
publication

Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice

Read more
01 Jul 2002
publication

Phospholipases C are involved in the virulence of Mycobacterium tuberculosis

Read more
14 Jun 2002
publication

Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria

Read more
01 May 2002
publication

Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis

Read more
01 May 2002
publication

Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis

Read more
01 Feb 2002
publication

Signal-sequence-independent secretion of the staphylococcal nuclease in Mycobacterium smegmatis

Read more
01 Feb 2002
publication

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.

Read more