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© Research
Publication : Infection and immunity

The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Apr 2004

Kocíncová D, Sondén B, Bordat Y, Pivert E, de Mendonça-Lima L, Gicquel B, Reyrat JM

Link to Pubmed [PMID] – 15039363

Infect. Immun. 2004 Apr;72(4):2379-82

Erp (exported repetitive protein) is a member of a mycobacterium-specific family of extracellular proteins. A hydrophobic region that is localized at the C-terminal domain and that represents a quarter of the protein is highly conserved across species. Here we show that this hydrophobic region is not essential for restoring the virulence and tissue damage of an erp::aph mutant strain of M. tuberculosis as assessed by bacterial counts and lung histology analysis in a mouse model of tuberculosis.

http://www.ncbi.nlm.nih.gov/pubmed/15039363