Ligne de temps
Brigitte Gicquel
Chercheur(euse) Permanent(e)
11 janv. 2023
publication
SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.
Lire plus04 mai 2020
publication
The antibiotic bedaquiline activates host macrophage innate immune resistance to bacterial infection
Lire plus28 août 2017
publication
Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis
Lire plus28 juil. 2015
28 juil. 2015
09 juin 2015
09 juin 2015
20 mars 2015
publication
bacterial infection drives the expression dynamics of microRNAs and their isomiRs
Lire plus25 juil. 2014
05 mars 2014
publication
Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis
Lire plus30 janv. 2014
publication
A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection
Lire plus17 août 2013
publication
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials
Lire plus12 avr. 2013
publication
Expression of TNF-alpha-dependent apoptosis-related genes in the peripheral blood of Malagasy subjects with tuberculosis
Lire plus01 avr. 2013
08 janv. 2013
publication
High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth
Lire plus13 déc. 2012
publication
Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic
Lire plus30 oct. 2012
publication
The balance of apoptotic and necrotic cell death in Mycobacterium tuberculosis infected macrophages is not dependent on bacterial virulence
Lire plus21 sept. 2012
publication
A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone
Lire plus07 août 2012
publication
Identification of DNA binding motifs of the Mycobacterium tuberculosis PhoP/PhoR two-component signal transduction system
Lire plus25 juil. 2012
publication
‘Z(S)-MDR-TB’ versus ‘Z(R)-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility
Lire plus04 juin 2012
publication
An interferon-related signature in the transcriptional core response of human macrophages to Mycobacterium tuberculosis infection
Lire plus29 févr. 2012
publication
After the bottleneck: Genome-wide diversification of the Mycobacterium tuberculosis complex by mutation, recombination, and natural selection
Lire plus30 janv. 2012
11 janv. 2012
publication
Combination of single nucleotide polymorphism and variable-number tandem repeats for genotyping a homogenous population of Mycobacterium tuberculosis Beijing strains in China
Lire plus10 janv. 2012
publication
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
Lire plus01 janv. 2012
publication
Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta.
Lire plus23 oct. 2011
publication
Population variation in NAIP functional copy number confers increased cell death upon Legionella pneumophila infection
Lire plus28 sept. 2011
publication
Molecular detection of fluoroquinolone-resistance in multi-drug resistant tuberculosis in Cambodia suggests low association with XDR phenotypes
Lire plus15 sept. 2011
publication
Mycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages
Lire plus07 juin 2011
publication
Genetic analysis of new 16S rRNA mutations conferring aminoglycoside resistance in Mycobacterium abscessus
Lire plus01 mai 2011
publication
Spoligotyping of clinical Mycobacterium tuberculosis isolates from the state of Minas Gerais, Brazil
Lire plus01 mars 2011
07 févr. 2011
publication
A first assessment of the genetic diversity of Mycobacterium tuberculosis complex in Cambodia
Lire plus20 janv. 2011
publication
Phylogeny of Mycobacterium tuberculosis Beijing strains constructed from polymorphisms in genes involved in DNA replication, recombination and repair
Lire plus20 janv. 2011
publication
Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237
Lire plus28 oct. 2010
publication
Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis
Lire plus25 oct. 2010
publication
Innate immune response to Mycobacterium tuberculosis Beijing and other genotypes
Lire plus24 sept. 2010
publication
Interactions of attenuated Mycobacterium tuberculosis phoP mutant with human macrophages
Lire plus09 sept. 2010
publication
High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling
Lire plus17 août 2010
publication
An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages
Lire plus17 juil. 2010
publication
Resolving lineage assignation on Mycobacterium tuberculosis clinical isolates classified by spoligotyping with a new high-throughput 3R SNPs based method
Lire plus12 mai 2010
publication
Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar
Lire plus25 févr. 2010
publication
Functional characterization of the Mycobacterium tuberculosis serine/threonine kinase PknJ
Lire plus04 août 2009
17 juil. 2009
publication
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
Lire plus01 mai 2009
15 avr. 2009
publication
MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques
Lire plus06 nov. 2008
publication
Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity
Lire plus23 oct. 2008
publication
PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence
Lire plus18 sept. 2008
publication
Capsular glucan and intracellular glycogen of Mycobacterium tuberculosis: biosynthesis and impact on the persistence in mice
Lire plus01 sept. 2008
29 août 2008
publication
The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv
Lire plus14 août 2008
publication
Effects of omega-3 and -6 fatty acids on Mycobacterium tuberculosis in macrophages and in mice
Lire plus01 juil. 2008
01 juil. 2008
publication
The evolution of drug resistance in Mycobacterium tuberculosis: from a mono-rifampin-resistant cluster into increasingly multidrug-resistant variants in an HIV-seropositive population
Lire plus06 févr. 2008
publication
Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis
Lire plus01 févr. 2008
publication
Mycobacterium bovis BCG-infected neutrophils and dendritic cells cooperate to induce specific T cell responses in humans and mice
Lire plus01 févr. 2008
publication
Live tuberculosis vaccines based on phoP mutants: a step towards clinical trials
Lire plus01 févr. 2008
publication
Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP
Lire plus30 janv. 2008
publication
Application of sensitive and specific molecular methods to uncover global dissemination of the major RDRio Sublineage of the Latin American-Mediterranean Mycobacterium tuberculosis spoligotype family
Lire plus02 janv. 2008
publication
Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages
Lire plus01 janv. 2008
publication
Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics
Lire plus05 oct. 2007
publication
Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients
Lire plus26 juil. 2007
publication
T-cell and serological responses to Erp, an exported Mycobacterium tuberculosis protein, in tuberculosis patients and healthy individuals
Lire plus19 juil. 2007
publication
Genetic basis for the biosynthesis of methylglucose lipopolysaccharides in Mycobacterium tuberculosis
Lire plus01 juin 2007
publication
Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli
Lire plus16 mai 2007
publication
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria
Lire plus16 mai 2007
publication
A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution
Lire plus01 janv. 2007
publication
Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis
Lire plus20 déc. 2006
15 déc. 2006
publication
Modification of the mycobacteriophage Ms6 attP core allows the integration of multiple vectors into different tRNAala T-loops in slow- and fast-growing mycobacteria
Lire plus04 déc. 2006
publication
Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility
Lire plus01 déc. 2006
publication
Humoral and cellular immune responses in sheep immunized with a 22 kilodalton exported protein of Mycobacterium avium subspecies paratuberculosis
Lire plus09 oct. 2006
publication
Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities
Lire plus09 oct. 2006
publication
Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages
Lire plus15 sept. 2006
publication
The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth
Lire plus01 sept. 2006
publication
Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic
Lire plus31 août 2006
publication
Biosynthesis of mycobacterial lipoarabinomannan: role of a branching mannosyltransferase
Lire plus31 juil. 2006
30 mai 2006
publication
Comparative investigation of the pathogenicity of three Mycobacterium tuberculosis mutants defective in the synthesis of p-hydroxybenzoic acid derivatives
Lire plus24 avr. 2006
publication
The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs
Lire plus05 avr. 2006
publication
DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population
Lire plus16 mars 2006
publication
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis
Lire plus06 mars 2006
publication
Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis
Lire plus13 janv. 2006
publication
Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes
Lire plus03 janv. 2006
publication
Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis
Lire plus01 janv. 2006
publication
Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients
Lire plus15 déc. 2005
publication
Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity
Lire plus02 déc. 2005
publication
The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis
Lire plus15 nov. 2005
publication
DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis
Lire plus01 nov. 2005
publication
Identification and characterization of an immunogenic 22 kDa exported protein of Mycobacterium avium subspecies paratuberculosis
Lire plus06 oct. 2005
29 sept. 2005
publication
The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region
Lire plus10 mai 2005
publication
Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes
Lire plus20 janv. 2005
publication
Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis
Lire plus01 janv. 2005
publication
Changes of the phagosomal elemental concentrations by Mycobacterium tuberculosis Mramp
Lire plus01 janv. 2005
publication
Reduced local growth and spread but preserved pathogenicity of a DeltapurC Mycobacterium tuberculosis auxotrophic mutant in gamma interferon receptor-deficient mice after aerosol infection
Lire plus01 juin 2004
publication
Recombinant Mycobacterium bovis BCG expressing the Sm14 antigen of Schistosoma mansoni protects mice from cercarial challenge
Lire plus01 avr. 2004
publication
The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis
Lire plus01 mars 2004
publication
Production of phthiocerol dimycocerosates protects Mycobacterium tuberculosis from the cidal activity of reactive nitrogen intermediates produced by macrophages and modulates the early immune response to infection
Lire plus16 févr. 2004
publication
The Erp protein is anchored at the surface by a carboxy-terminal hydrophobic domain and is important for cell-wall structure in Mycobacterium smegmatis
Lire plus01 févr. 2004
publication
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
Lire plus26 janv. 2004
publication
Adjuvant activity of Mycobacterium bovis BCG expressing CRM197 on the immune response induced by BCG expressing tetanus toxin fragment C
Lire plus22 déc. 2003
publication
Mycobacterium tuberculosis defective in phthiocerol dimycocerosate translocation provides greater protective immunity against tuberculosis than the existing bacille Calmette-Guérin vaccine
Lire plus01 oct. 2003
publication
Mucosal administration of three recombinant Mycobacterium bovis BCG-SIVmac251 strains to cynomolgus macaques induces rectal IgAs and boosts systemic cellular immune responses that are primed by intradermal vaccination
Lire plus01 août 2003
publication
Sulfolipid deficiency does not affect the virulence of Mycobacterium tuberculosis H37Rv in mice and guinea pigs
Lire plus08 juil. 2003
publication
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species
Lire plus01 juil. 2003
publication
Mutations in putative mutator genes of Mycobacterium tuberculosis strains of the W-Beijing family
Lire plus01 juil. 2003
publication
Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis
Lire plus25 juin 2003
publication
Mycobacterium tuberculosis Rv1395 is a class III transcriptional regulator of the AraC family involved in cytochrome P450 regulation
Lire plus01 juin 2003
publication
How is the phagocyte lectin keyboard played? Master class lesson by Mycobacterium tuberculosis
Lire plus01 juin 2003
01 juin 2003
publication
Deficiency in mycolipenate- and mycosanoate-derived acyltrehaloses enhances early interactions of Mycobacterium tuberculosis with host cells
Lire plus01 févr. 2003
publication
The shift of Th1 to Th2 immunodominance associated with the chronicity of Mycobacterium bovis bacille Calmette-Guérin infection does not affect the memory response
Lire plus01 janv. 2003
publication
The allele encoding the mycobacterial Erp protein affects lung disease in mice
Lire plus01 janv. 2003
publication
DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells
Lire plus20 déc. 2002
publication
The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan
Lire plus01 nov. 2002
publication
Extrapulmonary and pulmonary tuberculosis in antananarivo (madagascar): high clustering rate in female patients
Lire plus01 oct. 2002
01 août 2002
publication
Disruption of the gene homologous to mammalian Nramp1 in Mycobacterium tuberculosis does not affect virulence in mice
Lire plus01 juil. 2002
14 juin 2002
publication
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria
Lire plus01 mai 2002
publication
Evidence for a partial redundancy of the fibronectin-binding proteins for the transfer of mycoloyl residues onto the cell wall arabinogalactan termini of Mycobacterium tuberculosis
Lire plus01 mai 2002
publication
Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis
Lire plus01 févr. 2002
publication
Signal-sequence-independent secretion of the staphylococcal nuclease in Mycobacterium smegmatis
Lire plus01 févr. 2002
publication