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Responsable de Structure
Marco Bellinzoni (PI)
Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]
PTR 392 – Systems-wide analysis of Leishmania virulence
(EN) Fatma Z. Guerfali (PI)
This PTR aims to gain novel insight into the nature, the expression, and the regulation of Leishmania virulence factors through the investigation of genetics, transcriptomics, and proteomics differences between (i) virulent and avirulent L. […]
Development of a new statistical tool for the analysis of large HDX-MS data sets
Sébastien Brier (PI)
Hydrogen Deuterium eXchange followed by Mass Spectrometry (HDX-MS) is a recognized biophysical tool in structural biology capable of probing protein/ligand interactions, conformational changes, and protein folding and dynamics. The use of improved HDX-MS workflows […]
Post translational modifications (PTM)
Mariette Matondo (PI)
Post translational modifications (PTMs) are known to play pivotal roles in cellular physiology and disease, but only a few of the over 300 currently known modifications are extensively investigated in proteomic studies. The most […]
Mariette Matondo (PI)
Affinity Purification Mass Spectrometry (AP-MS) is the method of choice to study protein-protein interactions (PPI) and complexes under near physiological conditions. A protein of interest – the bait – is purified by either a […]
The LTQ-Velos Orbitrap is equipped with a U3000 nanoLC (Dionex) and ETD. It is mainly used for the analysis of simple mixtures of proteins after trypsin digestion or PTM analysis using its ETD capabilities.
The Q-Exactive Plus and Q-Exactive HF are equipped with an easy-nLC (Proxeon) and have been installed in 2014/2015. They are used for: Protein identification (Data Dependent and Data Independent Analyses) Post translational modification (PTM) analysis […]
2018CotL, a new morphogenetic spore coat protein of Clostridium difficile, Environ Microbiol. 2018 Dec 16. doi: 10.1111/1462-2920.14505.
2018eXL-MS: An Enhanced Cross-Linking Mass Spectrometry Workflow To Study Protein Complexes, Anal. Chem. 2018 Sep;90(18):10707-10714.
2018Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection, Sci Rep 2018 Mar;8(1):5170.
2018MUB Binds to Lactoferrin and Stands as a Specific Neutrophil Marker, Cell Chem Biol 2018 Apr;25(4):483-493.e9.
2017Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection, PLoS Pathog. 2017 Oct;13(10):e1006697.
2017Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates, Toxins (Basel) 2017 Sep;9(10).
2017Outer Membrane Proteome of A Diderm Firmicute of the Human Microbiome, Front Microbiol 2017;8:1215.
2017Proteome remodelling by the stress sigma factor RpoS/σ in Salmonella: identification of small proteins and evidence for post-transcriptional regulation, Sci Rep 2017 May;7(1):2127.
2017Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine, J. Proteome Res. 2017 04;16(4):1617-1631.
2016Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3, Cell Death Dis 2016 Oct;7(10):e2411.
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Proteomics Platform, Structural Mass Spectrometry and Proteomics Unit
Centre François Jacob – 2nd floor
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