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Responsable de Structure
Marco Bellinzoni (PI)
Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]
PTR 392 – Systems-wide analysis of Leishmania virulence
(EN) Fatma Z. Guerfali (PI)
This PTR aims to gain novel insight into the nature, the expression, and the regulation of Leishmania virulence factors through the investigation of genetics, transcriptomics, and proteomics differences between (i) virulent and avirulent L. […]
Development of a new statistical tool for the analysis of large HDX-MS data sets
Sebastien Brier (PI)
Hydrogen Deuterium eXchange followed by Mass Spectrometry (HDX-MS) is a recognized biophysical tool in structural biology capable of probing protein/ligand interactions, conformational changes, and protein folding and dynamics. The use of improved HDX-MS workflows […]
Post translational modifications (PTM)
Mariette Matondo (PI)
Post translational modifications (PTMs) are known to play pivotal roles in cellular physiology and disease, but only a few of the over 300 currently known modifications are extensively investigated in proteomic studies. The most […]
Mariette Matondo (PI)
Affinity Purification Mass Spectrometry (AP-MS) is the method of choice to study protein-protein interactions (PPI) and complexes under near physiological conditions. A protein of interest – the bait – is purified by either a […]
The LTQ-Velos Orbitrap is equipped with a U3000 nanoLC (Dionex) and ETD. It is mainly used for the analysis of simple mixtures of proteins after trypsin digestion or PTM analysis using its ETD capabilities.
The Q-Exactive Plus and Q-Exactive HF are equipped with an easy-nLC (Proxeon) and have been installed in 2014/2015. They are used for: Protein identification (Data Dependent and Data Independent Analyses) Post translational modification (PTM) analysis […]
2016Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3, Cell Death Dis 2016 Oct;7(10):e2411.
2016Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large-scale and targeted quantitative proteomics, Proteomics 2016 Oct;.
2016Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites, J. Exp. Med. 2016 Jul;.
2016The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A, Cell Rep 2016 Mar;14(11):2653-67.
2015Prediction of colorectal cancer diagnosis based on circulating plasma proteins, EMBO Mol Med 2015 Sep;7(9):1166-78.
2015The COPII complex and lysosomal VAMP7 determine intracellular Salmonella localization and growth, Cell. Microbiol. 2015 Dec;17(12):1699-720.
2014Quantitative ADME proteomics – CYP and UGT enzymes in the Beagle dog liver and intestine, Pharm. Res. 2015 Jan;32(1):74-90.
2014Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localization and dynamics, Mol. Cell Proteomics 2014 Jul;13(7):1769-86.
2014A repository of assays to quantify 10,000 human proteins by SWATH-MS., Scientific Data 1 (Nature) Article number: 140031 (2014).
2013Statistical approach to protein quantification, Mol. Cell Proteomics 2014 Feb;13(2):666-77.
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