I have been the manager of the Pasteur Proteomics facility since September 2013. I am responsible for the operations of the proteomics platform and the coordination of the different ongoing projects. I did my PhD research in the group of Dr. Bernard Monsarrat and Dr. Odile Schiltz at the Institute of Pharmacology and Structural Biology (IPBS, University Paul Sabatier, UPS, also known as Toulouse III, France). As part of my PhD work, I used high-resolution mass spectrometers, including the LTQ-Orbitrap, in combination with various quantitative proteomic approaches. My focus was on stable isotope labelling strategies (SILAC and ICAT) to study the proteasome inhibitor effect in acute myeloid leukaemia cells. I then moved to the Institute of Molecular Systems Biology in Eidgenössische Technische Hochschule (ETH Zürich) as a post-doctoral fellow in the group of Professor Ruedi Aebersold. I worked on multiple projects using mass spectrometry to assess changes in protein abundance and posttranslational modifications, e.g., ubiquitin, SUMO, and chlorination of proteins using discovery-driven and targeted mass spectrometry. During this time, I utilised the new data independent acquisition mode developed in Ruedi Aebersold Lab, namely SWATH-MS.
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2019Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype, PLoS Pathog. 2019 Jul;15(7):e1007945.
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2019Post-translational acylation controls the folding and functions of the CyaA RTX toxin, FASEB J. 2019 Jun;:fj201802442RR.
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2019Assembly and disassembly of Aspergillus fumigatus conidial rodlets, The Cell Surface (2019).
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2019The Adenylate Cyclase (CyaA) Toxin from Has No Detectable Phospholipase A (PLA) Activity In Vitro, Toxins (Basel) 2019 Feb;11(2).
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2019The puzzling construction of the conidial outer layer of Aspergillus fumigatus, Cell. Microbiol. 2019 May;21(5):e12994.
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2018Infection Reveals a Modification of SIRT2 Critical for Chromatin Association, Cell Rep 2018 Apr;23(4):1124-1137.
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2018Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection, Sci Rep 2018 Mar;8(1):5170.
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2018MUB Binds to Lactoferrin and Stands as a Specific Neutrophil Marker, Cell Chem Biol 2018 Apr;25(4):483-493.e9.
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2017Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection, PLoS Pathog. 2017 Oct;13(10):e1006697.
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2017Characterization of Post-Translational Modifications and Cytotoxic Properties of the Adenylate-Cyclase Hemolysin Produced by Various Bordetella pertussis and Bordetella parapertussis Isolates, Toxins (Basel) 2017 Sep;9(10).
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